Breast cancer and type 2 diabetes are major health concerns worldwide. This thesis has focused on novel non-canonical roles of two complement inhibitors, which led to the discovery of new mechanisms and factors at play in these diseases. The sushi domain-containing protein 4 (SUSD4) was previously portrayed as a breast cancer suppressor, but no mechanism was identified. In paper I, using a syngene

Introduction: Investigation of bone marrow (BM) trephine biopsies and/or clot sections by CD34 immunohistochemistry (IHC) testing has been used by pathologists for several decades, and its clinical value has been well established with QBEND10 being the most frequently used primary antibody (Ab) clone. However, most other parameters related to the IHC protocol as well as the readout vary widely bet

How does discomfort affect research interviewing? Recent contributions suggest that researchers do not always experience discomfort as problematic but also as productive. We explore our experiences of, and strategies for, uncomfortable interviews. Based on experiences of interviewing right-wing populist Twitter activists in the United States and Sweden, we make four claims. First, discomfort may a

Evidence shows psychological factors (e.g. stress) are linked to immunity, yet there is a lack of research investigating the complex interactions between psychological factors and immune function. Network analysis is useful to investigate complex interrelations between relevant health-related variables. This study applied network analyses to examine associations between psychological protective fa

This paper examines the development of the Artificial Intelligence (AI) meta-debate in Sweden before and after the release of ChatGPT. From the perspective of agenda-setting theory, we propose that it is an elite outside of party politics that is leading the debate – i.e. that the politicians are relatively silent when it comes to this rapid development. We also suggest that the debate has become This paper examines the development of the Artificial Intelligence (AI) meta-debate in Sweden before and after the release of ChatGPT. From the perspective of agenda-setting theory, we propose that it is an elite outside of party politics that is leading the debate – i.e. that the politicians are relatively silent when it comes to this rapid development. We also suggest that the debate has become

Quantitative analysis of large-scale political text data in the form of word embeddings has great potential for systematising differences between political parties. We examine the differences between embeddings obtained from speakers from the two competitors for the PM position in Sweden (Social Democrats and Moderates) over a 30-year period. The goal is to compare how off-the-shelf general pre-trQuantitative analysis of large-scale political text data in the form of word embeddings has great potential for systematising differences between political parties. We examine the differences between embeddings obtained from speakers from the two competitors for the PM position in Sweden (Social Democrats and Moderates) over a 30-year period. The goal is to compare how off-the-shelf general pre-tr

Background: Osteocalcin is a metabolic active hormone, which correlates positively with bone formation and inversely with body mass index and waist circumference in adults. Objectives: To investigate whether osteocalcin in infancy and early childhood were related to childhood growth or body composition. Methods: A Swedish longitudinal birth cohort with blood samples from 551 children from birth un

Background Uncertainty is present in many situations in dental practice, but must not prevent wise clinical decision-making. Dental education should acknowledge uncertainty and teach useful management strategies. This study explored if dental students are aware of, and comfortable with uncertainty. The aims were to (i) measure students’ comfort or discomfort with and awareness of uncertainty while

Aim: To audit adherence to the Swedish paediatric guidelines for urinary tract infections (UTIs) in infants. Secondary objectives were to compare findings on imaging performed according to the guidelines with imaging without guideline support and to identify predictors of non-adherence. Methods: A prospective multicentre study of infants

Anion exchange membranes (AEMs) play a vital role in AEM water electrolysis (AEMWE), a promising technology for hydrogen production. However, it remains challenging to develop AEMs that simultaneously achieve high OH− conductivity, robust alkaline stability, and sustained operational performance in AEMWE. In the present study, we report on a class of high-performance, readily synthesized AEMs base

I mitt arbete som nybliven doktorand på Musikhögskolan i Malmö avser jag fördjupa kunskapsbilden kring folkmusikens gehörsmetod, hur den vuxit fram och etablerats och hur den används idag, framför allt inom ramen för den svenska kulturskolan.I mötet mellan folkmusikens och kulturskolans respektive pedagogiska traditioner synliggörs flera spänningar som har betydelse för bl.a. inkludering, tillgäng

Politics interferes with sport, whether we like it or not, not least in foreign policy. Despite this, the history of Swedish sport's foreign policy is largely unwritten. Is there a common thread in how the sports movement has related to nations that for one reason or another are perceived as controversial or reprehensible? What criteria does the sports movement use to decide who should and should

The article analyzes how central and eastern European members of the EU relate to the main nodes of the EU’s politics of memory, such as the first and second world wars, the Holocaust as Europe’s negative founding myth, Soviet Communism being equally as criminal as the Nazi regime, expulsions as a pan-European trauma, the legacy of colonialism, Europe as a continent of immigration, and Europe’s po

This paper explores the shift in family influence on socio-economic outcomes, focusing on sibling relationships, from the sixteenth to the nineteenth centuries in the Barcelona area. Our findings reveal a diminishing role of vertical ties (parents–children) and an increasing significance of horizontal ties (between siblings). Specifically, brothers who were first in the sibling group to marry exer

Detta dokument presenterar ett antal olika metoder som kan användas för användarmedverkanThis document contains a description of different methods that can be used for user involvement in a design process.

BACKGROUND: Upper gastrointestinal bleeding (UGIB) is a common and potentially fatal medical emergency. This study aimed to investigate the frequency, causes, outcomes, and efficacy of endoscopy in the treatment of UGIB at King Fahad Central Hospital in Jazan, Saudi Arabia.METHODS: Between January 2017 and December 2023, a retrospective study was performed including all hospitalized patients with