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Background: Pancreatic cancer has the lowest survival rate among all the major cancer types. Although recent decades have seen advances in diagnostic imaging, surgical techniques, perioperative care and oncological treatment, this has not been translated into major improvements in clinical outcome. The 5-year survival rate remains less than 10% for all stages. One important unmet clinical need is
Aberrant stem cell-like gene regulatory networks are a feature of leukaemogenesis. The ETS-related gene (ERG), an important regulator of normal haematopoiesis, is also highly expressed in T-ALL and acute myeloid leukaemia (AML). However, the transcriptional regulation of ERG in leukaemic cells remains poorly understood. In order to discover transcriptional regulators of ERG, we employed a quantita
As the global power generation is shifted toward renewable and intermittent sources, the importance of fuel cells and other energy storage and conversion devices is continually increasing. However, many of these technologies are still under development and further research is necessary before they can be implemented. This is the case for the hydroxide exchange membrane fuel cell (HEMFC), which has
Non-coagulating (NC) milk is unwanted in cheese production, as it lowers cheese yield and prolongs processing time. Less yield will lead to economic losses at the dairies. Even if NC milk has been found in several breeds, studies suggest that Swedish Red Dairy cattle (RDC) has a higher frequency of NC milk than most other breeds. In order to strengthen the competitiveness of Swedish RDC and ensure
Interactions between cortical areas were studied during the search for verbal associations and reading of words. The functional anatomy and the sequence of involvement of cortical areas during the solution of these tasks have been described previously, in studies using positron emission tomography and multichannel recordings of evoked potentials combined with identification of the locations of dip
Cortical connectivity was studied in tasks of generating the use of words in comparison with reading aloud the same words. These tasks were used earlier in PET and high-density ERP recording studies, which described both the functional anatomy and time course of involvement of cortical areas in word processing. We developed a new method for studying the synchrony of EEG spectral components within
Spectral EEG powers were compared in 4 frequency ranges (8-13, 15-25, 25-35, and 35-45 Hz) in a group of 20 subjects during the performance of tasks requiring mental rotation of two- and three-dimensional objects. Only those EEG segments corresponding to tasks with identical solution times were analyzed. The spectral powers of oscillations in the alpha range were higher in control conditions than
Reflection in EEG parameters of the process of solving two types of mental tasks, i.e. spatial-imaginary and verbal-logical, was investigated in nine test-subjects. Mental efforts were found to specify EEG spatiofrequency patterns depending on the task type and subject's identity. These patterns were unique and reproducible enough to enable identification of this or the other type of mental task w
The EEG spectral power in 4 frequency ranges (8-13, 15-25, 25-35, and 35-45 Hz) was studied during mental rotation of two- and three-dimensional objects. Only those EEG segments were analyzed which corresponded to the tasks with similar time of solving. The EEG spectral power of the alpha range was higher under control conditions than during task solving. The spectral power in the range of 15-45 H
Solution of spatial and verbal tasks was studied in 43 subjects using the advanced version of the method of intracortical interaction mapping (IIM) and analysis of EEG spectra in short (250 ms) intervals. Comparison between the IIM and coherence methods during solving simple motor tasks revealed some advantages of the IIM for studying of labile cortical connections. Several stages were separated i
The stages of the mental rotation of complex three-dimensional figures were investigated in nine healthy subjects using the intracortical interaction mapping technique. It was established that mental rotation is accomplished with the participation of both parietal regions; the prerotation setup is associated with the involvement of the frontal, central, and right temporal divisions of the brain; d
Effect of sustained mental work on the first stage of mental rotation was studied by the method of intracortical interaction. It was revealed that during sustained mental work the zone of the high level of connections in the alpha-band was considerably reduced due to an increase of specificity, rationality of thinking. In the beta-band the zone of the high connection level moved from the central a
The stages of mental rotation of complicated three-dimensional figures were studied using the intracortical interaction mapping. The role of the parietal areas in the mental rotation was shown. The frontal, central and the right temporal areas are involved in the prerotation setup. Both frontal areas and the left temporo-parieto-occipital areas participate in decision making and verbal response. I
Orthostatic hypertension, which appears to be mediated through excess neurohumoral activation while standing, is a common blood pressure trait among patients with and without arterial hypertension. However, lack of consensus regarding the definition of orthostatic hypertension makes it difficult to assess the true prevalence of this condition. Orthostatic hypertension appears to predict the risk f
Although diagnostic criteria have been developed characterizing postural orthostatic tachycardia syndrome (POTS), no single set of criteria is universally accepted. Furthermore, there are gaps in the present criteria to identify individuals who have this condition. The reproducibility of the physiological findings, the relationship of symptoms to physiological findings, the presence of symptoms al
The management of diabetic foot ulcers (DFU) remains a challenge, and there is continuing uncertainty concerning optimal approaches to wound healing. The International Working Group of the Diabetic Foot (IWGDF) working group on wound healing has previously published systematic reviews of the evidence in 2008, 2012 and 2016 to inform protocols for routine care and to highlight areas which should be
The rheology of dense suspensions in the viscous regime can be characterized by the viscous number J and granular flows by the inertia number I, both relating the shear rate γ - to the confining pressure P. Furthermore, several works have shown that the rheology of suspensions and granular flows can be unified, and this unification is used to characterize suspensions with non-negligible particle i
Concentrations of aerosol particles in Poland and their sources are rarely discussed in peer-reviewed journal articles despite serious air quality issues. A source apportionment of carbonaceous aerosol particles was performed during winter at a rural background environment field site in north-eastern Poland. Data were used of light absorption at seven wavelengths and levoglucosan concentrations al
