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Installation of O-glycan sulfation capacities in human HEK293 cells for display of sulfated mucins

The human genome contains at least 35 genes that encode Golgi sulfotransferases that function in the secretory pathway, where they are involved in decorating glycosaminoglycans, glycolipids, and glycoproteins with sulfate groups. Although a number of important interactions by proteins such as selectins, galectins, and sialic acid-binding immunoglobulin-like lectins are thought to mainly rely on su

Safety of early hospital discharge following admission with ST-elevation myocardial infarction treated with percutaneous coronary intervention : A nationwide cohort study

Background: The Second Primary Angioplasty in Myocardial Infarction (PAMI-II) risk score is recommended by guidelines to identify low-risk patients with ST-elevation myocardial infarction (STEMI) for an early discharge strategy. Aims: We aimed to assess the safety of early discharge (≤2 days) for low-risk STEMI patients treated with primary percutaneous coronary intervention (PCI). Methods: Using

Indicator frameworks for fostering open knowledge practices in science and scholarship

The aim of this report is to contribute to the European vision for Open Science (European Commission 2016) by providing the frameworks for understanding and applying science and technology indicators, defined broadly, to enable the transition from the current scientific and scholarly system towards a more open and inclusive configuration of knowledge practices and infrastructures. Indicators for O

The Supported Osteoarthritis Self-Management Programme in primary health care. Patient-reported outcomes and physiotherapists´ experiences.

Abstract Background: Osteoarthritis (OA) is a disabling joint disease affecting about 300 million people worldwide. Today, there is no cure for OA and treatment focuses on relieving symptoms. Guidelines recommend education, exercise, and weight control, as first-line treatment. In Sweden, first-line treatment is offered as a Supported Osteoarthritis Self-Management Programme (SOASP) combining educ

Rally-around-the-organizational-flag? Internal communication in a professional organization during the Covid-19 pandemic crisis

Purpose: This study aims, first, to explore and analyze if and how organizational members’ professions or occupations influence perceptions of internal crisis communication. The second, related, aim is to discuss the role of internal communication in creating a strong organizational identity during a prolonged crisis such as the Covid-19 pandemic. Design/methodology/approach: This study is mainly

Estimation of Panel Data Models with Random Interactive Effects and Multiple Structural Breaks when T is Fixed

In this article, we propose a new estimator of panel data models with random interactive effects and multiple structural breaks that is suitable when the number of time periods, T, is fixed and only the number of cross-sectional units, N, is large. This is done by viewing the determination of the breaks as a shrinkage problem, and to estimate both the regression coefficients, and the number of bre

Production of π0 and η mesons in U+U collisions at sNN =192 GeV

The PHENIX experiment at the Relativistic Heavy Ion Collider measured π0 and η mesons at midrapidity in U+U collisions at sNN=192 GeV in a wide transverse momentum range. Measurements were performed in the π0(η)→γγ decay modes. A strong suppression of π0 and η meson production at high transverse momentum was observed in central U+U collisions relative to binary scaled p+p results. Yields of π0 and

Measurement of J/ψ at forward and backward rapidity in p+p, p+Al, p+Au, and He 3 +Au collisions at sNN =200 GeV

Charmonium is a valuable probe in heavy-ion collisions to study the properties of the quark gluon plasma, and is also an interesting probe in small collision systems to study cold nuclear matter effects, which are also present in large collision systems. With the recent observations of collective behavior of produced particles in small system collisions, measurements of the modification of charmon

Octupole states in Tl 207 studied through β decay

The β decay of Hg207 into the single-proton-hole nucleus Tl207 has been studied through γ-ray spectroscopy at the ISOLDE Decay Station (IDS) with the aim of identifying states resulting from coupling of the πs1/2-1, πd3/2-1, and πh11/2-1 shell model orbitals to the collective octupole vibration. Twenty-two states were observed lying between 2.6 and 4.0 MeV, eleven of which were observed for the fi

First observation of an attractive interaction between a proton and a cascade baryon

This Letter presents the first experimental observation of the attractive strong interaction between a proton and a multistrange baryon (hyperon) Ξ-. The result is extracted from two-particle correlations of combined p-Ξ-S.p-Ξ+ pairs measured in p-Pb collisions at sNN=5.02 TeV at the LHC with ALICE. The measured correlation function is compared with the prediction obtained assuming only an attract

“K−pp” a K‾-meson nuclear bound state, observed in 3He(K−,Λp)n reactions

We observed a distinct peak in the Λp invariant mass spectrum of He3(K−,Λp)n, well below mK+2mp, i.e., the mass threshold of the K− to be bound to two protons. By selecting a relatively large momentum-transfer region q=350∼650 MeV/c, one can kinematically separate the peak from the quasi-free process, K‾N→K‾N followed by the non-resonant absorption by the two spectator-nucleons K‾NN→ΛN. We found t

AtlFast3: The Next Generation of Fast Simulation in ATLAS

The ATLAS experiment at the Large Hadron Collider has a broad physics programme ranging from precision measurements to direct searches for new particles and new interactions, requiring ever larger and ever more accurate datasets of simulated Monte Carlo events. Detector simulation with Geant4 is accurate but requires significant CPU resources. Over the past decade, ATLAS has developed and utilized

J/ψ and ψ (2S) production at forward rapidity in p+p collisions at s =510 GeV

The PHENIX experiment at the Relativistic Heavy Ion Collider has measured the differential cross section, mean transverse momentum, mean transverse momentum squared of inclusive J/ψ, and cross section ratio of ψ(2S) to J/ψ at forward rapidity in p+p collisions at s=510 GeV via the dimuon decay channel. Comparison is made to inclusive J/ψ cross sections measured at s=200 GeV and 2.76-13 TeV. The re

Production of Λ and KS0 in jets in p–Pb collisions at sNN=5.02 TeV and pp collisions at s=7 TeV

The production of Λ baryons and KS0 mesons (V0 particles) was measured in p–Pb collisions at sNN=5.02 TeV and pp collisions at s=7 TeV with ALICE at the LHC. The production of these strange particles is studied separately for particles associated with hard scatterings and the underlying event to shed light on the baryon-to-meson ratio enhancement observed at intermediate transverse momentum (pT) i

Analyses of the complex formation of staphylococcal enterotoxin A and the human gp130 cytokine receptor

Superantigens (SAgs) are bacterial enterotoxins produced by Staphylococcus aureus. Staphylococcal enterotoxin type A (SEA), a staphylococcal superantigen, has been shown to bind to the cytokine signalling receptor glycoprotein 130 (gp130). The structural details, as well as the exact physiological role of this interaction, remain unclear. Here, we describe the structural details of the SEA–gp130 c