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Small-angle X-ray scattering (SAXS) measurements reveal a striking difference in intermolecular interactions between two short highly charged peptides - deca-arginine (R10) and deca-lysine (K10). Comparison of SAXS curves at high and low salt concentration shows that R10 self-associates, while interactions between K10 chains are purely repulsive. The self-association of R10 is stronger at lower io
Background: Quality of supervision is a major predictor for successful PhD projects. A survey showed that almost all PhD students in the Health Sciences in Denmark indicated that good supervision was important for the completion of their PhD study. Interestingly, approximately half of the students who withdrew from their program had experienced insufficient supervision. This led the Research Educa
Excessive aggression is a common behaviour problem in dogs that can have various destructive effects on the affected people and the implicated dog. Aggressive behaviour directed towards the owner or other family members is one of the most frequently occurring aggressive phenotypes. Here, we examine the reliability of a short questionnaire assessing aggressive behaviours by two, contextually differ
While priority setting for research, development and innovation (RDI) traditionally focuses on which thematic areas should be supported, less is known about how such goals are implemented on the agency level. Key challenges are how to translate broad priorities into programs and projects, how to govern the knowledge base, and how to handle organizational tensions during implementation. Many of the
Since it embarked on its economic opening and reform path in the late 1970s, the Chinese government has assigned a central role to science, technology and innovation for the country's economic development. In the phase of 'economic catch-up', China has pursued a top-down innovation policy, characterized by targeted investments in science and technology. Recently, a significant shift in China's inn
Background: Voice and swallowing problems are often seen in patients with advanced larynx cancer, after total laryngectomy (TL) and chemo/radiotherapy. The aim of this study was to determine the occurrence of voice and swallowing problems in patients who have been laryngectomised and investigate if these symptoms were related to age, time after TL, radiotherapy and TNM-classification. In addition,
eMobility is a hot topic, in the public policy area as well as in business and scientific communities. Literature on electric freight transport is still relatively scarce. Urban freight transport is considered as one of the most promising fields of application of vehicle electrification, and there are ongoing demonstration projects. This paper will discuss case study examples of electric freight v
Non-stationary signals are very common in nature, e.g. sound waves such as human speech, bird song and music. It is usually meaningful to describe a signal in terms of time and frequency. Methods for doing so exist and are well defined. From the time representation it is possible to see the oscillations or waves of the signal and if the signal changes over time. From the frequency representation,
The objective of this study is to explore the following: (1) the impact of two different initial doses and cumulative 2-year dose of rituximab (RTX) on drug adherence and predictors of adherence to treatment in rheumatoid arthritis (RA) patients in an observational clinical setting, (2) immunoglobulin levels (IgG/IgM/IgA) during repeated treatment and their relation to infections, and (3) developm
Background: Upper extremity deep vein thrombosis (UEDVT) constitutes around 10% of all DVT, and can cause both pulmonary embolism (PE) and postthrombotic syndrome (PTS) in the arm. The incidence of secondary UEDVT is increasing due to widespread use of central venous catheters in patients with cancer and other chronic diseases. The safety and efficacy of using new direct acting oral anti coagulant
Background: The risk of cancer is increased and affects survival after lung transplantation (LTx), but has not been well characterized in COPD. We aimed to evaluate the incidence and prognosis of cancer following LTx for COPD. Methods: A prospective, population-based study of patients undergoing LTx for end-stage COPD at the two transplantation centers in Sweden between 1990−2013, with follow-up f
The reassigned spectrogram can be used to improve the readability of a time-frequency representation of a non-stationary and multi-component signal. However for transient signals the reassignment needs to be adapted in order to achieve good localisation of the signal components. One approach is to scale the reassignment. This paper shows that by adapting the shape of the time window used with the
Type 2 diabetes is a complex trait with both environmental and hereditary factors contributing to the overall pathogenesis. One link between genes, environment, and disease is epigenetics influencing gene transcription and, consequently, organ function. Genome-wide studies have shown altered DNA methylation in tissues important for glucose homeostasis including pancreas, liver, skeletal muscle, an
Pulmonary arterial hypertension (PAH) is a life-threatening condition, characterized by an imbalance of vasoactive substances and remodeling of pulmonary vasculature. Nitric oxide, formed from l-arginine, is essential for homeostasis and smooth muscle cell relaxation in PAH. Our aim was to compare plasma concentrations of l-arginine, asymmetric dimethylarginine (ADMA), and symmetric dimethylargini
Following the recent Global Carbon Project (GCP) synthesis of the decadal methane (CH4) budget over 2000-2012 (Saunois et al., 2016), we analyse here the same dataset with a focus on quasi-decadal and inter-annual variability in CH4 emissions. The GCP dataset integrates results from top-down studies (exploiting atmospheric observations within an atmospheric inverse-modelling framework) and bottom-
The development of good writing skills is fundamental not only to publish scientific results, but also to have a deeper understanding of complex subjects. However reports from the Swedish Higher Education Authority from 2012-2015 suggest that engineering students at Lund University have unsatisfactory academic writing skills. Our paper investigates how students of the Faculty of Engineering at Lun
This paper proposes a novel Doppler penalty kernel used in the computation of multitapers corresponding to the Wigner-Ville distribution. The resulting multitaper spectrogram will approximately fulfil the time-frequency concentration of the Wigner-Ville distribution but also suppress the cross-terms outside a signal dependent Doppler bandwidth, making the penalty kernel appropriate for linear freqThis paper proposes a novel Doppler penalty kernel used in the computation of multitapers corresponding to the Wigner-Ville distribution. The resulting multitaper spectrogram will approximately fulfil the time-frequency concentration of the Wigner-Ville distribution but also suppress the cross-terms outside a signal dependent Doppler bandwidth, making the penalty kernel appropriate for linear freq
