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Understanding acceleration : An interplay between different mathematics and physics representations

Acceleration is often viewed as abstract - but when a person accelerates, e.g. in a car or on swings, trampolines, carousels or rollercoasters, the force required for the acceleration is felt throughout the body. If acceleration is introduced as force divided by mass rather than as a second derivative of displacement, the concept can be made accessible to much younger learners, such as 10-year old

Training teachers to use playgrounds in physics teaching

Climbing racks, carousels, swings and slides can be used for many experiments and demonstrations that offer suprising results, often challenging students' understanding of motion. This paper describes activities used in professional development workshops for teachers on the use of playgrounds in physics teaching. Toys and other simple equipment complement the experience of the body. In addition, s

Antibody-Fragments: Protein Engineering, Process Development, and their Application as Affinity Ligands

Monoclonal antibody (mAb) fragments have become the formats of choice for both biopharmaceuticals and ligands in analytical and preparative applications. Their smaller size enables additional advantages over full-length mAbs, such as improved tissue penetration, faster blood clearance for diagnostic applications, improved capacity, and enablement of multivalent formatting. However, limitations in Monoclonal antibody (mAb) fragments have become the formats of choice for both biopharmaceuticals and ligands in analytical and preparative applications. Their smaller size enables additional advantages over full-length mAbs, such as improved tissue penetration, faster blood clearance for diagnostic applications, improved capacity, and enablement of multivalent formatting. However, limitations in

High spin states of the normally deformed bands of y 83

Level lifetime and side-feeding time measurements were performed on the excited states of the normally deformed bands of Y83 using the Doppler-shift attenuation method (DSAM). The high spin states of Y83 were populated using the fusion-evaporation reaction Ni58(S32,α3p)Y83 at 135 MeV. Twenty-two level lifetime and side-feeding times were determined in most of the cases by comparing the line shapes

Radio channel measurement and modelling techniques

This chapter is dedicated to radio channel measurement and modelling techniques for beyond 4G networks, in particular: • new measurement techniques not only targeting radio channels, but also material properties in new frequency bands (Section 9.1), • improved physical models, cowering full-wave as well as ray-based methods, with a specific sub-section dealing with diffuse scattering (DS) and comp

Organisational models of Health services for Children and adolescents in out-of-home care: Health technology assessment

AimDecades of research confirm that children and adolescents in out‐of‐home care (foster family, residential care) have much greater health care needs than their peers. A systematic literature review was conducted to evaluate organisational health care models for this vulnerable group.MethodsA systematic literature search was undertaken of the following databases: Academic Search Elite, CENTRAL, C

To shake or not to shake : 13 C-based evidence on anaerobic methane oxidation in paddy soil

The anaerobic oxidation of methane (AOM) removes most of the biologically produced methane (CH 4 ) from marine ecosystems before it enters the atmosphere and thus mitigates greenhouse gas emissions. As compared to marine environments, surprisingly little is known about the role of AOM in terrestrial ecosystems. Particularly, how AOM controls the CH 4 budget of paddy soils is unexplored, partly

Maize phenology alters the distribution of enzyme activities in soil : Field estimates

Microbial processes mediated by soil enzymes are crucial in soil organic matter decomposition, resulting in release of nutrients that become available for plant and microbial uptake. Therefore, it is crucial to know the sensitivity of enzyme activities (EA) along soil depths at distinct plant vegetation stages, and how the availability of mineral nitrogen (N) alters EA. We studied effects of N fer

Decadal Nitrogen Fertilization Decreases Mineral-Associated and Subsoil Carbon : A 32-Year Study

Crop residues and manure are important sources of carbon (C) for soil organic matter (SOM) formation. Crop residue return increases by nitrogen (N) fertilization because of higher plant productivity, but this often results only in minor increases of SOM. In our study, we show how N fertilization and organic C additions affected SOM and its fractions within a 32-year-long field-experiment at Puch,

Microbial decomposition of soil organic matter is mediated by quality and quantity of crop residues : mechanisms and thresholds

Crop residue quality and quantity have contrasting effects on soil organic matter (SOM) decomposition, but the mechanisms explaining such priming effect (PE) are still elusive. To reveal the role of residue quality and quantity in SOM priming, we applied two rates (5.4–10.8 g kg−1) of 13C-labeled wheat residues (separately: leaves, stems, roots) to soil and incubated for 120 days. To distinguish P

An acid-compatible co-polymer for the solubilization of membranes and proteins into lipid bilayer-containing nanoparticles

The fundamental importance of membrane proteins in drug discovery has meant that membrane mimetic systems for studying membrane proteins are of increasing interest. One such system has been the amphipathic, negatively charged poly(styrene-co-maleic acid) (SMA) polymer to form "SMA Lipid Particles" (SMALPs) which have been widely adopted to solubilize membrane proteins directly from the cell membra

Influence of Poly(styrene-co-maleic acid) Copolymer Structure on the Properties and Self-Assembly of SMALP Nanodiscs

Polymer stabilized nanodiscs are self-assembled structures composed of a polymer belt that wraps around a segment of lipid bilayer, and as such are capable of encapsulating membrane proteins directly from the cell membrane. To date, most studies on these nanodiscs have used poly(styrene-co-maleic acid) (SMA) with the term SMA-lipid particles (SMALPs) coined to describe them. In this study, we have

Unravelling cationic cellulose nanofibril hydrogel structure : NMR spectroscopy and small angle neutron scattering analyses

Stiff, elastic, viscous shear thinning aqueous gels are formed upon dispersion of low weight percent concentrations of cationically modified cellulose nanofibrils (CCNF) in water. CCNF hydrogels produced from cellulose modified with glycidyltrimethylammonium chloride, with degree of substitution (DS) in the range 10.6(3)-23.0(9)%, were characterised using NMR spectroscopy, rheology and small angle

Decyltrimethylammonium Bromide Micelles in Acidic Solutions : Counterion Binding, Water Structuring, and Micelle Shape

Wide-angle neutron scattering experiments combined with empirical potential structural refinement modeling have been used to study the detailed structure of decyltrimethylammonium bromide micelles in the presence of acid solutions of HCl or HBr. These experiments demonstrate considerable variation in micelle structure and water structuring between micelles in the two acid solutions and in comparis

Thermal stability, storage and release of proteins with tailored fit in silica

Biological substances based on proteins, including vaccines, antibodies, and enzymes, typically degrade at room temperature over time due to denaturation, as proteins unfold with loss of secondary and tertiary structure. Their storage and distribution therefore relies on a “cold chain” of continuous refrigeration; this is costly and not always effective, as any break in the chain leads to rapid lo

Microwave-assisted deep eutectic-solvothermal preparation of iron oxide nanoparticles for photoelectrochemical solar water splitting

Here, we present a new microwave-solvothermal method for the preparation of iron oxide nanostructures using deep eutectic solvents as a more sustainable reaction medium. By varying the synthesis temperature and solvent water fraction, the methodology offers control over iron oxide phase, size, and morphology, using efficient, rapid (10 minute) microwave heating. Synthesis with pure DES gives small