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First Evidence of Acyl-Hydrolase/Lipase Activity From Human Probiotic Bacteria: Lactobacillus rhamnosus GG and Bifidobacterium longum NCC 2705

Lactobacillus rhamnosus GG (ATCC 53103) and Bifidobacterium longum NCC 2705 are among the most studied probiotics. However, the first evidence of acyl hydrolase/lipase of two annotated proteins, one in each genome of these strains, is reported in this work. Signal peptide analysis has predicted that these proteins are exported to the extracellular medium. Both proteins were produced in Escherichia

Repositioning of fluoroquinolones from antibiotic to anti-cancer agents: An underestimated truth

Increasing development costs and higher failure rate in clinical trials has reduced the repertoire of newer drugs in the market for clinical use. The most appropriate approach to end the search for newer drugs is “Repositioning”, as it requires less time and money to explore new indication of existing drug or failed drug. In the past, several drugs have been repositioned for different indication b

A Grounding Physicalist Solution to the Causal Exclusion Problem

Remember how Kim (Philos Perspect 3:77–108, 1989, in: Heil and Mele (eds) Mental causation, Clarendon Press, Oxford, 1993b) used to argue against non-reductive physicalism to the effect that it cannot accommodate the causal efficacy of the mental? The argument was that if physicalists accept the causal closure of the physical, they are faced with an exclusion problem. In the original version of th

Decreased HLA-DQ expression on peripheral blood cells in children with varying number of beta cell autoantibodies

The risk for type 1 diabetes is strongly associated with HLA-DQ and the appearance of beta cell autoantibodies against either insulin, glutamate decarboxylase (GAD65), insulinoma-associated protein-2 (IA-2), or zinc transporter 8 (ZnT8). Prolonged exposure to autoantibodies may be related to T cell exhaustion known to occur in chronic infections or autoimmune disorders. It was hypothesized that au

Shah of Iran Commemoration

On July 27, 1980, at 9:45 am in Cairo, Egypt, the Shah of Iran, Mohammad Reza Pahlavi, took a long deep breath and passed away. He had lost his long battle against a blood cancer which was kept a secret from his closest confidants and even his Queen, Farah Pahlavi, for years. Today marks the 42nd commemoration of the Shah´s death and even though the majority of the Iranians were born after the Isl

Iran och USA återgår nu till status quo

Status quo har nu uppstått mellan Iran och USA. Om inte Iran ger sig på amerikaner och om Donald Trump använder en mer de-eskalerande ton, kommer nästa milstolpe i denna konflikt i novembermånad när USA går till val.The conflict between Iran and the United States has escalated, but now they are returning to status quo.

“O, Shah of Iran, Return Back to Iran”

For 39 years the Islamic Republic have been in power in Iran. Millions of books, articles, movies, series, radio programs and speeches have been produced by the regime to demolish the Shah. For 39 years have the propaganda machines of the regime been active in tyrannizing the Shah. And yet, they have failed.

Assessment of groundwater safety surrounding contaminated water storage sites using multivariate statistical analysis and Heckman selection model: a case study of Kazakhstan

Petrochemical enterprises in Kazakhstan discharge polluted wastewater into special recipients. Contaminants infiltrate through the soil into the groundwater, which potentially affects public health and environment safety. This paper presents the evaluation of a 7-year monitoring program from one of the factories and includes nineteen variables from nine wells during 2013–2019. Several multivariate

Synthesis of molecularly imprinted polymers using a functionalized initiator for chiral-selective recognition of propranolol

We present a new concept of synthesis for preparation of molecularly imprinted polymers using a functionalized initiator to replace the traditional functional monomer. Using propranolol as a model template, a carboxyl‐functionalized radical initiator was demonstrated to lead to high‐selectivity polymer particles prepared in a standard precipitation polymerization system. When a single enantiomer o

Boronic Acid Modified Polymer Nanoparticles for Enhanced Bacterial Deactivation

A new method has been developed to enhance the antibacterial efficiency of traditional antibiotics. Chloramphenicol‐imprinted polymer particles were decorated with boronic acid to improve their binding to both Gram‐negative and ‐positive bacteria. The polymer particles have a high antibiotic loading and provide a slow release of the antibiotic payload to deactivate the target bacteria. The boronic

Validation of a general subjective well-being factor using Classical Test Theory

Background: Subjective Well-Being (SWB) is usually conceptualized in terms of an affective (i.e., judgements of biological emotional reactions and experiences) and a cognitive component (i.e., judgements of life satisfaction in relation to a psychological self-imposed ideal). Recently, researchers have suggested that judgements of harmony in life can replace or at least complement the cognitive co

Amino-functionalised silica-grafted molecularly imprinted polymers for chloramphenicol adsorption

This research investigated the liquid-phase removal of chloramphenicol (CAP), an emerging contaminant using molecularly imprinted polymers (MIPs). CAP adsorption profiles, equilibrium, and kinetics were analysed. The adsorption performance was compared between MIPs and non-imprinted polymers (NIPs), both with silica or without silica grafting. The imprinting factor (IF) values for the Si@MIPs-CAP

The role of epistemic signalling in transdisciplinary knowledge production : Examples from the field of sustainable water management

The number of arrangements where academia collaborates with governmental andnongovernmental organisations, as well as industries, have increased over the last decades.While research has focused on whether knowledge produced in such collaborations is genuinelyinfluenced by others than the ‘experts’, or those with the highest status and power, this reportexplores the influence of framings and re-fra

Predicting the fate of chlorinated aliphatics by hydrogeological modelling and DCIP data - Färgaren case study

We present a local flow model approach for the transport and the decay of a roughly 50 year old perchloroethylene contamination at a former dry cleaning facility at Kv. Färgaren in Kristianstad that sits above the largest aquifer in Sweden. The study demonstrates an efficient workflow integrating ERT for conceptualising and calibrating a three dimensional transient, multi aquifer groundwater trans