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The current debate on the Anthropocene is thus far dominated by the natural sciences. This leads to a simplistic analysis of environmental devastation and the underlying changes of human-nature relations. In this commentary, we urge the discipline of political science to enhance its engagement in the debate on the so-called human age and its far-reaching implications. The Anthropocene is character
Background: Post heart-transplant survival has increased, but information is lacking on specific causes of death and life expectancy. We aimed to assess cause-specific loss of life-years compared to the general population, evaluate classification for cause of death after heart transplantation, and assess validity of cause of death data from the International Society of Heart and Lung Transplant (I
Based on Marcus theory, the photoinduced electron transfer properties of D-A type non-fullerene acceptor organic solar cells (OSCs) under the dependence of external electric field (Fext) were investigated. The research results shown that the charge transfer mode under different Fext intensities changes with certain regularity. Focusing on the important parameters (ΔG, λ, and VDA) that affect the c
Depressive symptoms are associated with altered pupillary responses during learning and reward prediction as well as with changes in neurometabolite levels, including brain concentrations of choline, glutamate and gamma-aminobutyric acid (GABA). However, the full link between depressive symptoms, reward-learning-related pupillary responses and neurometabolites is yet to be established as these con
The fast growth of e-commerce and omni/multi-channel retailing brings new challenges for efficient inventory management. One such challenge concerns service differentiation across channels when upstream central warehouses satisfy both direct customer demand and replenishment orders from downstream retailers. Motivated by industry collaboration, we address this issue by developing a combined stock
The parallel time of a population protocol is defined as the average number of required interactions in which an agent in the protocol participates, i.e., the quotient between the total number of interactions required by the protocol and the total number n of agents, or just roughly the number of required rounds, where a round stands for a sequence of n consecutive interactions. This naming trigge
Equivalence ratio measurements are of great importance for combustion systems. In this paper, femtosecond laser filament-triggered discharge plasma spectroscopy is proposed for one-dimensional equivalence ratio measurements of combustion flow fields. The optical emission spectra of femtosecond laser filament-triggered discharge plasma in methane-air premixed laminar flames were measured. The spect
We report a novel approach for single-shot planar imaging of CH3 radicals in premixed methane and air flames. A 213 nm beam from the 5th harmonic of an Nd:YAG laser was resonantly absorbed by the CH3 radicals, which were excited to the highly pre-dissociative upper level and dissociated to H2 and CH (X), as the main dissociation channel. The CH radicals were consequently excited by a 388 nm beam f
Atmospheric pressure discharge plasma is widely utilized in industry and science. However, due to the spatiotemporal uncertainty of the natural discharge, it is difficult to measure the discharge plasma spectra with a high spatiotemporal resolution. This prevents the accurate investigation of discharge plasma evolution and limits further applications. Here, we harnessed a femtosecond laser filamen
Structured lipids with desired properties can be produced by enzymatic transesterification. This is a multistep reaction with many factors influencing both the product yield and quality. In this study, the single and combined effects of water activity, temperature and substrate ratio were studied on the reaction between high oleic sunflower oil and ethyl stearate producing 1,2-stearin-3-olein (SOS
Vegetable oils and fats are major energy sources but also play an essential part in the physical and chemical properties of food products. The current change in the climate is affecting harvest yields, leading to a shortage and increased prices of raw materials that are difficult to replace. In addition, there is an increasing demand for new products with positive health effects.Triacylglycerols (
Abstract This chapter contributes to the current debate on ideology,social movements and political activities in a branded society. Adoptinga sociological perspective on brands as platforms, the chapter shows howbrands support grass-roots social movements to structure their politicalactions. Through the analysis of the Five Star Movement (M5S), a digitalpolitical party, the chapter illustrates how
Injections of pre-formed α-synuclein fibrils (PFFs) or overexpression of α-synuclein using AAV vectors are commonly used as models of Parkinson-like synucleinopathy in rats and mice. In the modified method reviewed here, the "SynFib" model, the PFFs and the AAV vector are administered together unilaterally into the substantia nigra. This approach combines the key features of these two models, i.e.
The molecular architecture of sugar-based surfactants strongly affects their self-assembled structure, i.e., the type of micelles they form, which in turn controls both the dynamics and rheological properties of the system. Here, we report the segmental and mesoscopic structure and dynamics of a series of C16 maltosides with differences in the anomeric configuration and degree of tail unsaturation
We have developed an efficient approach to generate functional induced dopaminergic (DA) neurons from adult human dermal fibroblasts. When performing DA neuronal conversion of patient fibroblasts with idiopathic Parkinson's disease (PD), we could specifically detect disease-relevant pathology in these cells. We show that the patient-derived neurons maintain age-related properties of the donor and
To provide insights into the fate of transposable elements (TEs) across timescales in a post-polyploidization context, we comparatively investigate five sibling Dactylorhiza allotetraploids (Orchidaceae) formed independently and sequentially between 500 and 100K generations ago by unidirectional hybridization between diploids D. fuchsii and D. incarnata. Our results first reveal that the paternal
Parkinson's disease (PD) is the second most common neurodegenerative disorder worldwide and is caused by the degeneration and loss of dopamine (DA) neurons in the ventral midbrain (VM). The focal and progressive degeneration of DA neurons in the VM makes PD a particularly attractive target for cell-based therapies. Human pluripotent stem cells (hPSCs) offer unprecedented opportunities to model the
A growing body of evidence suggests that astrocytes play a major role in the pathophysiology of Alzheimer's disease. Given that APOE is primarily expressed in astrocytes, these cells might be an important link between the APOE ϵ4 allele and the development of Alzheimer's disease pathology. Here, we investigate this hypothesis in vivo by measuring myo-inositol, a metabolite involved in astrocytic f
Heat exchanger network synthesis (HENS) is an effective tool for heat recovery in chemical and petrochemical industries. This study aims to show a method for HENS with the consideration of different shell-side flow arrangements in shell-and-tube heat exchangers. The proposed MINLP model is modified from the stage-wise superstructure model, incorporating newly developed correlations for shell-side
