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This paper discusses the evolutionary function of certain advanced aspects of cognition, like planning, self-awareness, and free will. The inner environment of an agent consists of all representations which the agent can actively "think about". A distinction is made between immediate planning, where plans are made for present needs, and anticipatory planning, where future needs are predicted. Huma

Evidence for a rapid sea-level rise at 7600 years ago

Dating the transgression and subsequent regression in marginal basins of the southeastern Swedish Baltic Sea provides a new perspective of global ice-volume changes and the isostatic adjustment of the mantle after the retreat of the Scandinavian Ice Sheet from this area. Superimposed upon a smooth pattern of local sea-level rise, acceleration occurred ca. 7600 calibrated (cal) yr B.P., evidenced a

A cross-linked hyaluronic acid hydrogel (Healaflow(®)) as a novel vitreous substitute.

Vitrectomy requires the substitution of the natural vitreous, as well as tamponading of retinal breaks. Clinically available alternatives such as gas and silicone oil have side effects such as inflammation, secondary glaucoma, cataract, and a need for head posturing. In this study, a hydrogel of cross-linked sodium hyaluronic acid (Healaflow(®)) is evaluated for use as a novel vitreous substitute.

‘One moral improvement, more allied to the machinery of life than perhaps any other’: Mid-nineteenth-century punctuality in context

Mid-nineteenth-century Britain saw a significant output of fictional texts, conduct books and tracts with an explicit focus on the concept of punctuality. This article examines a number of such texts by linking the notion of punctuality to the general nineteenthcentury wish for self-improvement and social progress. Three central facets of midnineteenth-century punctuality are identified and discus

The Lim-only protein LMO2 acts as a positive regulator of erythroid differentiation

LMO2, a member of the LIM-only protein family, is essential for the regulation of hematopoietic stem cells and formation of erythroid cells. It is found in a transcriptional complex comprising LMO2, TAL1, E47, GATA-1, and LDB1 which regulates erythroid genes. While TAL1 has been shown to induce erythroid differentiation, LMO2 appears to suppress fetal erythropoiesis. In addition to LMO2, the close

Challenges in the development of strategies for housing adaptation evaluations

Founded on recent empirical experiences and results from a Housing Adaptation Project accomplished in a Swedish municipality, this paper aims to elucidate and problematize challenges inherent in the process of developing research-based strategies for housing adaptation (HA) evaluations feasible for municipality contexts. In this paper, theory and conceptual definitions of client-level outcomes rel

Uterine venous blood flow in normal and complicated pregnancies: a methodological study.

OBJECTIVE.: Finding of venous congestion at histopathological examination of placenta indicates the importance of abnormal placenta-maternal venous return. The present descriptive study investigates the possibility of recording Doppler flow signals from maternal uterine veins. MATERIAL AND METHODS.: Transabdominal Doppler ultrasound examinations of uterine veins on both sides of uterus were perfor

Who are "the parties"? Article 31 §3(c) and the "Principle of Systemic Integration" Revisited

Over the last couple of years, international lawyers have hotly debated the correct way to apply Article 31, paragraph 3(c) of the 1969 Vienna Convention on the Law of Treaties. Discussions have focused on the meaning of ‘the parties’. Traditionally this expression has always been interpreted in the stricter sense of all parties to the interpreted treaty. Voices are now raised suggesting a broader

Extended pelvic lymphadenectomy for prostate cancer: Will the previously reported benefits be reproduced in hospitals with lower surgical volumes?

Objective. In the European Association of Urology guidelines on prostate cancer an extended pelvic lymphadenectomy (ePLND) is now recommended, instead of a dissection limited to the obturator fossae (lPLND). This recommendation relies on studies reporting that metastatic disease is identified twice as often with ePLND as with lPLND, with only moderately increased complications. However, these stud

HbA1c räcker inte vid screening för störd glukosmetabolism - Även glukosbelastning behövs, visar svensk prospektiv epidemiologisk studie.

An HbA1c threshold of ≥42 mmol/mol has been proposed to diagnose prediabetes. The sensitivity, specificity and positive predictive value of the proposed threshold for detection of individuals with prediabetes was examined in a study of 573 randomly selected individuals from Vara and Skövde. In addition, the utility of the FINDRISC questionnaire and of a fasting glucose test in combination with thr

Operational tolerance in nonvascularized transplant models induced by AR-C117977, a monocarboxylate transporter inhibitor.

AR-C117977, a monocarboxylate transporter inhibitor, reduces immune responses both in vitro and in vivo, maintains long-term graft survival, and induces operational tolerance. To evaluate the immunosuppressive limitations of AR-C117977, this study was performed in nonvascularized transplant models noted for their refractive response to standard immunosuppressive agents. Rat skin was transplanted f

Programming industrial robots using advanced input-output devices: test-case example using a CAD package and a digital pen based on the Anoto technology

Interaction with robot systems for specification of manufacturing tasks and motions needs to be simple, to enable wide-spread use of robots in SMEs. In the best case, existing practices from manual work could be used, to smoothly let current employees start using robot technology as a natural part of their work. Our aim is to simplify the robot programming task by allowing the user to simply make

Kronofogdekostnader i nytt förenklat tvistemål

En ansökan om betalningsföreläggande avvisas eller avskrivs för att gäldenären inte kan delges. Borgenären ansöker om stämning avseende samma sak. En omtvistad fråga — som rör förenklade tvistemål och tolkningen av 18 kap. 8 a § sjätte stycket rättegångsbalken — är om borgenären i tingsrättsförfarandet kan få ersättning för kostnaden hos Kronofogdemyndigheten. I denna artikel argumenteras för att