The aim of this thesis was to elucidate the role of nitric oxide (NO) in the transduction signalling of insulin and glucagon release by stimulating or inhibiting islet endogenous NO-production as well as by using NO donors. Insulin release stimulated by L-arginine, the substrate for constitutive NO-synthase (cNOS)-catalyzed NO-production, was increased by the selective NOS-inhibitor NG-nitro-L-arg

Popular Abstract in Swedish Vad har jag gjort de senaste åren? Och varför? Det är det många som har undrat. Så stundtals även jag. Vad jag skriver nedan syftar inte till att förklara detta, utan är bara ämnat som en kort introduktion. Jag har de senaste åren jobbat med gener och proteiner från både växter och bakterier. Både gener och proteiner är väldigt små saker, men även den minsta lilla sak This thesis deals with the structure and function of two different enzymes, ferrochelatase and magnesium chelatase, that catalyse similar reactions. When this work started, a three-dimensional model of ferrochelatase existed. Much was known about the enzyme, but some details remained unclear. The focus has been to establish where the metal and the porphyrin binds to the enzyme, and how they are pu

The history of Bureau of American Ethnology

This study examined the molecular mechanisms of neutrophil migration to sites of mucosal bacterial infection. (1) Bacterial induction of neutrophil chemotactic cytokines and their role in neutrophil migration. Uropathogenic E.coli were shown to stimulate urinary tract epithelial cells to produce a specific array of cytokines including the neutrophil chemoattractant IL-8. IL-8 production was depen

Ett forskningsprojekt IMPOERS har startats för att följa en cohort sjuksköterskestudenter under implementering av OER. Detta är ett av de första mer systematiska projekten i Sverige om införande av OER. Några första preliminära resultat kommer att kunna presenteras vid NU2014,hösten 2014. Bakgrund Sjuksköterskeprogrammet på Högskolan Dalarna fick i januari 2013 utmärkelsen Excellent eLärande efte

Popular Abstract in Swedish Måndagen den 16:e april 2001 informerade det amerikanska företaget Cisco, med produkter och tjänster inom nätverk och datakommunikation, att de skulle skriva ned sitt komponentlager med 2,2 miljarder dollar. Detta skedde i samband med en globalt vikande efterfrågan och det som skulle komma att kallas IT-bubblan i folkmun. Investerare och företagsledning ställde sig frågThis dissertation presents a framework for describing, a process for identifying, and a model for evaluating misalignments in the supply chain when varying elements such as structure, processes, and management components. The developed approach makes it possible to address and improve the alignment of supply chain structures, processes, and management components. To further increase knowledge of h

Popular Abstract in Swedish Traditionellt sett är resande en maskulin aktivitet. I det här sammanhanget betyder det att resan för en euro-amerikansk man ses som en identitetsskapande process som formar honom som subjekt. Denna process förutsätter att kvinnan figurerar i marginalen, i det stereotypiska fallet som sexobjekt eller väntande hustru/moder. Genom att ersätta män med kvinnor i huvudrollerThis thesis is founded on the premise that traditional discourses of travel and mobility are inherently masculinist, that is, travel is seen as a masculinity rite-of passage for the Euro-American male, shaping his subjectivity through the othering and marginalization of women. Taking Jack Kerouac’s On the Road (1957), the epitome of masculinist travel literature, as a starting point for an examina

Radionuclide therapy requires patient-specific planning of the absorbed dose to target volumes, in most cases tumours, in order to achieve an expected biological effect, taking into account that the absorbed doses to normal organs and tissues should be kept as low as reasonably achievable. Therefore, the calculation of absorbed doses has to be as accurate as possible. The accuracy depends on the m

A review of literature related to fire evacuation in high-rise buildings was carried out with the objectives to (1) identify the key behavioural factors associated with the event of a fire in a high-rise building, (2) review the current procedures and strategies currently adopted in high-rise buildings (e.g. horizontal and vertical evacuation methods, phased evacuation, total evacuation, defend-in

Critical infrastructures provide indispensable services to society and extensive disruption of these give rise to large societal consequences. Most risk-related studies of critical infrastructures, however, focus rather narrowly on the direct consequences, e.g. expressed by services not supplied or cost of nonsupplied services. Although these measures might serve as a proxy for the direct societal

Existing installations and energy systems in most commercial buildings could be used in a more efficient way to provide savings – both in terms of energy and load demand. The key for effective operation is a thorough and detailed analysis of energy use patterns that creates essential baseline for energy savings and the development of demand response (DR) strategies. The knowledge of energy deman