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Identification of novel diagnostic biomarkers for deep venous thrombosis

The combination of a negative D-dimer and a Wells score can rule out, but not confirm, a diagnosis of deep venous thrombosis (DVT). We aimed to identify new diagnostic biomarkers for DVT and to investigate their relationship with hypercoagulability markers [D-dimer and activated protein C-protein C inhibitor (APC-PCI) complex]. We screened 92 cardiovascular-specific proteins in plasma samples from

Fifth Åland Island conference on von Willebrand disease

The fifth Åland Island meeting on von Willebrand disease (VWD) was held on the Åland Islands, Finland, from 22 to 24 September 2016—90 years after the first case of VWD was diagnosed in a patient from the Åland Islands in 1926. This meeting brought together experts in the field of VWD to share knowledge and expertise on current trends and challenges in VWD. Topics included the storage and release

“I am Satan!” black metal, Islam and blasphemy in Turkey and Saudi Arabia

During the last decade, black metal bands have recorded anti-Islamic music in Turkey and Saudi Arabia. Black metal is renowned for being anti-authoritarian and especially against organized religion. As such, black metal music is a strong expression of protest against, and repudiation of, society, manifesting social pressure, and contrasting with the discursively normal. Using the results from two

Hypothesis-testing demands trustworthy data-a simulation approach to inferential statistics advocating the research program strategy

In psychology as elsewhere, the main statistical inference strategy to establish empirical effects is null-hypothesis significance testing (NHST). The recent failure to replicate allegedly well-established NHST-results, however, implies that such results lack sufficient statistical power, and thus feature unacceptably high error-rates. Using data-simulation to estimate the error-rates of NHST-resu

Data Descriptor : Wide-field corneal subbasal nerve plexus mosaics in age-controlled healthy and type 2 diabetes populations

A dense nerve plexus in the clear outer window of the eye, the cornea, can be imaged in vivo to enable non-invasive monitoring of peripheral nerve degeneration in diabetes. However, a limited field of view of corneal nerves, operator-dependent image quality, and subjective image sampling methods have led to difficulty in establishing robust diagnostic measures relating to the progression of diabet

CGRP as the target of new migraine therapies — successful translation from bench to clinic

Treatment of migraine is on the cusp of a new era with the development of drugs that target the trigeminal sensory neuropeptide calcitonin gene-related peptide (CGRP) or its receptor. Several of these drugs are expected to receive approval for use in migraine headache in 2018 and 2019. CGRP-related therapies offer considerable improvements over existing drugs as they are the first to be designed s

A Mesoproterozoic iron formation

We describe a 1,400 million-year old (Ma) iron formation (IF) from the Xiamaling Formation of the North China Craton. We estimate this IF to have contained at least 520 gigatons of authigenic Fe, comparable in size to many IFs of the Paleoproterozoic Era (2,500–1,600 Ma). Therefore, substantial IFs formed in the time window between 1,800 and 800 Ma, where they are generally believed to have been a

Amniotic fluid INSL3 measured during the critical time window in human pregnancy relates to cryptorchidism, hypospadias, and phthalate load : A large case-control study

The period of the first to second trimester transition in human pregnancy represents a sensitive window for fetal organogenesis, particularly in regard to the development of the male reproductive system. This is a time of relative analytical inaccessibility. We have used a large national biobank of amniotic fluid samples collected at routine amniocentesis to determine the impacts of exogenous endo

Complete polarization control

The polarization state of isolated attosecond pulses generated by high-order harmonic generation can now be manipulated at will. The development opens the door for a multitude of ultrafast experiments to investigate chiral media.

Circularizing Planet Nine through dynamical friction with an extended, cold planetesimal belt

Unexpected clustering in the orbital elements of minor bodies beyond the Kuiper belt has led to speculations that our Solar system actually hosts nine planets, the eight established plus a hypothetical 'Planet Nine'. Several recent studies have shown that a planet with a mass of about 10 Earth masses on a distant eccentric orbit with perihelion far beyond the Kuiper belt could create and maintain

Investigation of the absorption Ångström exponent and its relation to physicochemical properties for mini-CAST soot

In this work, a mini-CAST soot generator was used to produce soot with different optical and physicochemical characteristics. Absorption Ångström exponents (AAE) expressing the absorption wavelength dependence were assessed by multiwavelength in-situ and filter-based (aethalometer) laser extinction. The two optical techniques showed good agreement. For the chosen mini-CAST operating conditions, AA

Spectroscopic differences in posterior insula in patients with chronic temporomandibular pain

Chronic pain including temporomandibular disorder (TMD) pain involves a complex interplay between peripheral and central sensitization, endogenous modulatory pathways, cortical processing and integration and numerous psychological, behavioral and social factors. The aim of this study was to compare spectroscopic patterns of N-Acetyl-aspartate (NAA), total creatine (tCr), choline (Cho), myo-inosito

Mobile lidar system for environmental monitoring

A versatile mobile remote sensing system for multidisciplinary environmental monitoring tasks on the Chinese scene is described. The system includes a 20 Hz Nd:YAG laser-pumped dye laser, optical transmitting/receiving systems with a 30 cm and a 40 cm Newtonian telescope, and electronics, all integrated in a laboratory, installed on a Jiefang truck. Results from field experiments on atomic mercury

CW Laser radar for combustion diagnostics

A CW-laser radar system developed for combustion diagnostics is described. The system is based on triangulation to attain range information. A portable system has been constructed and here we show some result from measurements in various flames, for example Rayleigh scattering thermometry and monitoring of particle distributions with high temporal and spatial resolution. The concept can equally we

Travelling Business Models : On adapting business models to new contexts

“Fråga mig inte var jag kommer ifrån, fråga mig var jag känner mig hemma”. Citatet är hämtat från en TED presentation av Taiye Selasi som handlar om att vissa människor känner sig hemma på flera ställen i världen samtidigt. Inte nödvändigtvis där de kommer från. I min forskning fokuserar jag på affärsmodeller för solenergi som sprids till och etableras på nya marknader. En affärsmodell är en abstrHow business models are configured can provide one solution to bringing forward sustainable innovations and transforming businesses and industries so that they become more sustainable. Creating a shift in the energy sector’s use of renewable sources is of particular importance since the energy sector is the source of one-fourth of all global greenhouse gas emissions. In California, the dominant bu

Insect remote sensing using a polarization sensitive cw lidar system in Chinese rice fields

A joint Chinese-Swedish field campaign of Scheimpflug continuous-wave lidar monitoring of rice-field flying pest insects was pursued in very hot July weather conditions close to Guangzhou, China. The occurrence of insects, birds and bats with almost 200 hours of round-the-clock polarization-sensitive recordings was studied. Wing-beat frequency recordings and depolarization properties were used for

Inelastic hyperspectral lidar for aquatic ecosystems monitoring and landscape plant scanning test

We have developed an aquatic inelastic hyperspectral lidar with unrestricted focal-depth and enough sensitivity and spatio-temporal resolution to detect and resolve position and behavior of individual sub-millimeter aquatic organisms. We demonstrate ranging with monitoring of elastic echoes, water Raman signals and fluorescence from chlorophyllbearing phytoplankton and dye tagged organisms. The sy

Short-Wave infrared atmospheric scheimpflug lidar

Atmospheric dual-band Scheimpflug lidar is demonstrated at 980 and 1550 nm. Signals are compared during three weather conditions, and the spatio-temporal resolution of the atmospheric structure is considered. The potential for aerosol classification is evaluated, and future directions are discussed.

Impaired vibrotactile sense in children and adolescents with type 1 diabetes – Signs of peripheral neuropathy

Objective To investigate whether multi-frequency vibrometry can identify individuals with elevated vibration perception thresholds (VPTs), reflecting impaired vibrotactile sense, among children and adolescents with type 1 diabetes. Methods In 72 pediatric patients with type 1 diabetes, VPTs were evaluated for seven frequencies on two sites of the hand, and five frequencies on two sites of the foot