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In dual control, the manipulated variables are used to both regulate the system and identify unknown parameters. The joint probability distribution of the system state and the parameters is known as the hyperstate. The paper proposes a method to perform dual control using a deep reinforcement learning algorithm in combination with a neural network model trained to represent hyperstate transitions.
We investigate the impact of impurity configuration on electronic and optical properties of YVO4 through application of plane-wave DFT. Since this crystal is a common host material for optical devices and it has been widely used as a phosphor and a laser host material, it is important to identify a correlation between impurity location and the intrinsic properties of the material. To further impro
Following years of increasing bureaucracy and micro-management, there is a need for more trust in the judgement of street-level professionals and citizens in the public administration. After an intense debate in Sweden for several years, the Swedish Government launched a trust reform in 2016. This was organized around a government commission, called the Trust Commission. At the centre of its work
Demokratin kräver en fin väv av normer och strukturer för att kunna fungera. De fria allmänna valen är bara en del av många i denna väv. En annan del är starka och modiga professioner i det offentliga kärnuppdraget. Med sitt omdöme och sin professionella etik utgör dessa grupper en trygghet för våra medborgare och för deras talan i många situationer. Det finns flera skäl till att offentlig styrnin
Genom att öka handlingsutrymmet för medarbetarna i kärnuppdraget kan offentlig sektor bli mer effektiv och serviceinriktad. Grunden är en styrning som präglas av tillit och lyhördhet. Tillit är nödvändigt för att vårt samhälle ska stå starkt och för att statliga myndigheter, kommuner och regioner ska lyckas med sina uppdrag. Men hur bygger vi tilliten?I den här boken får du en introduktion till hu
OBJECTIVE: To investigate the influence of intravenous (iv) fluid volumes on the secretion of N-terminal-pro-brain natriuretic peptide (NT-Pro-BNP) in colorectal surgical patients and its association with cardiopulmonary complications (CPC). In addition, to examine if preoperative NT-Pro-BNP can predict the risk for postoperative CPC. METHODS: Blood samples from patients enrolled in a previously p
Background Implementation in healthcare is often slow and poorly reported. Results include suboptimal outcomes and ad-verse consequences for patients. However, promising tools to remedy implementation speed and reporting already exist – such as the evidence-based, fast-track implementation model (Fast-IM) and the comprehensive RE-AIM (reach, effectiveness, adoption, implementation, and maintenance
Inom Svenska kyrkan talas idag ofta om vikten av att rekrytera ideella medarbetare. I en tid då de ekonomiska resurserna minskar blir det viktigt att på nytt arbeta med människors engagemang. Vi har vant oss vid att de anställda medarbetarna är många, men hur och varför växte de stora arbetslagen fram?Detta är en bok om hur lekmannamedarbetare kom att bli en naturlig del av den församlingsverksamh
Background: Infertile men with non-obstructive azoospermia (NOA) have impaired spermatogenesis. Dilated and un-dilated atrophic seminiferous tubules are often present in the testes of these patients, with the highest likelihood of active spermatogenesis in the dilated tubules. Little is known about the un-dilated tubules, which in NOA patients constitute the majority. To advance therapeutic strate
Antibiotic resistance is a major worldwide concern, and new drugs with mechanistically novel modes of action are urgently needed. Here, we report the structure-based drug design, synthesis, and evaluation in vitro and in cellular systems of sialic acid derivatives able to inhibit the bacterial sialic acid symporter SiaT. We designed and synthesized 21 sialic acid derivatives and screened their aff
Early reports raised concern that use of non-steroidal anti-inflammatory drugs (NSAIDs) may increase risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19). Users of the COVID Symptom Study smartphone application reported use of aspirin and other NSAIDs between March 24 and May 8, 2020. Users were queried daily about symptoms, COVID-19 testing, and healthcare seeki
INTRODUCTION: Since 2005, disease-related human genetic diversity has been intensively characterized using genome-wide association studies (GWAS). Understanding how and by whom this work was performed may yield valuable insights into the generalizability of GWAS discoveries to global populations and how high-impact genetics research can be equitably sustained in the future.MATERIALS AND METHODS: W
Purpose: The available questionnaires for quality-of-life (QoL) assessments are age-group specific, limiting comparability and impeding longitudinal analyses. The comparability of measurements, however, is a necessary condition for gaining scientific evidence. To overcome this problem, we assessed the viability of harmonising data from paediatric and adult patient-reported outcome (PRO) measures.
Major atmospheric oxidants (OH,O3 and NO3) dominate the atmospheric oxidation capacity, while H2SO4 is considered as a main driver for new particle formation. Although numerous studies have investigated the long-term trend of ozone in Europe, the trends of OH, NO3 and H2SO4 at specific sites are to a large extent unknown. The one-dimensional model SOSAA has been applied in several studies at the S
