Background: Few studies have analysed the long-term effects of biological treatment in psoriasis. PsoReg, the Swedish national register for systemic psoriasis treatment, started in 2006 and now includes 10 years of real-world data on the effectiveness of biological treatment. Objectives: To analyse the long-term real-world outcome data of patients who are biologically naïve with moderate-to-severe

År 1900 blev botanisten Carl Lindman ansvarig för återutgivningen av en hundra år gammal illustrerad flora, J. W. Palmstruchs Svensk botanik (1802–43). De gamla handkolorerade kopparsticken undersöktes noggrant, korrigerades och försågs med nya förstorade detaljer och trycktes sedan med färglitografi. I denna artikel studeras, ur ett bokhistoriskt perspektiv, hur den nya formen påverkar innehålletIn 1900 the Swedish botanist Carl Lindman was assigned responsibility for the republication of a one-hundred-year old illustrated flora, J. W. Palmstruch’s Svensk botanik (1802–43). The old hand-colored copperplates were meticulously examined, corrected, and supplied with new magnified details and then printed in color lithographs. This article closely examines, from a book historical perspective,

Basing their study on conceptualizations current in anthropology, history, memory studies, and cultural sociology, Eleonora Narvselius and Gelinada Grinchenko offer a new, complex approach to understanding the violations of loyalty and trust that constitute betrayal, as well as their present-day revisions. Acts of betrayal and their subsequent reinterpretations are viewed through the prism of powe

The article explores ways in which the nineteenth-century Prussian military architecture has been used and promoted as a part of the local heritage in the Russian exclave of Kaliningrad. Accommodation of the old fortification buildings to tourism and museum work has been publicly discussed since the beginning of the 2000s, but neither local nor federal authorities have proposed a plan to adapt the

Bose-Einstein correlations between identified charged pions are measured for p+Pb collisions at sNN=5.02TeV using data recorded by the ATLAS detector at the CERN Large Hadron Collider corresponding to a total integrated luminosity of 28nb-1. Pions are identified using ionization energy loss measured in the pixel detector. Two-particle correlation functions and the extracted source radii are presen

Taking for granted the view that belief-less, ‘non-doxastic’, engagement with religion is possible, this article discusses the proper object of such religiosity. Its focus is the claim of J. L. Schellenberg that non-doxastic religion should be directed at ’simple ultimism’. I argue that ‘simple ultimism’ is too abstract to allow for alignment with religious reality. Traditional religion is a bette

Presentation

This paper has re-analysed and compared data between three studies conducted in the United Kingdom and in Sweden (the OPUS ‘Older People's Use of Unfamiliar Space’ study in the United Kingdom and the Swedish studies ‘Let's Go for a Walk’ and ‘Walking in Old Age’) to provide a comprehensive account of the issues facing older people in the outdoor environment. All three studies draw on the ‘fit’ bet

Parasites are expected to exert long-term costs on host fecundity and longevity. Understanding the consequences of heritable polymorphic variation in disease defence in wild populations is essential in order to predict evolutionary responses to changes in disease risk. Telomeres have been found to shorten faster in malaria-diseased individuals compared with healthy ones with negative effects on lo

When a human catches a ball, they estimate future target location based on the current trajectory. How animals, small and large, encode such predictive processes at the single neuron level is unknown. Here we describe small target-selective neurons in predatory dragonflies that exhibit localized enhanced sensitivity for targets displaced to new locations just ahead of the prior path, with suppress

Visually guided predation is range-limited in water, but works over long distances on land. This may have driven our last aquatic ancestors to evolve large eyes on the top of their head for spotting crunchy meals on ancient riverbanks.

Fan worms (Annelida: Sabellidae) are sessile polychaetes that spend their adult lives in tubes and project their fans, composed of radiolar tentacles, up into the water column for respiration and filter feeding. To protect the fan from predation, many species have evolved unique compound eyes on the radioles that function as shadow or motion detectors, eliciting a rapid withdrawal response in reac