Assembly of MHC class I molecules in the ER is regulated by the so-called loading complex (LC). This multiprotein complex is of definite importance for class I maturation, but its exact organization and order of assembly are not known. Evidence implies that the quality of peptides loaded onto class I molecules is controlled at multiple stages during MHC class I assembly. We recently found that tap

The years 1988-1998 were named by World Council of Churches as The Ecumenical Decade - Churches in Solidarity with Women. On a worldwide scale, the Decade challenged member churches to portray Solidarity with Women in their contexts. Churches around the world launched a variety of projects and programs for this purpose. The Decade envisaged a new fellowship of women and men in church and society,

There is now considerable evidence for the involvement of K+ channels in nitric oxide (NO) induced relaxation of smooth muscles including the myometrium. In order to assess whether apamin-sensitive K+ channels play a role in NO - induced relaxation of the human uterus, we have studied the effect of specific blockers of these channels on the relaxation of myometrium from non-pregnant women. In vitr

The non-peptide ET-receptor antagonist Bosentan was used to investigate the role of endogenous endothelin-1 (ET-1) in the development of the Sephadex-induced lung inflammation in the rat. Intratracheal instillation of Sephadex caused a 60-fold rise in endothelin-1-like-immunoreactivity (ET-1-LI) in bronchoalveolar lavage fluid (BALF) concomitant with development of lung oedema, an influx of inflam

1. Several recent in vitro studies have suggested that production of nitric oxide (NO) from the islet NO system may have an important regulatory influence on the secretion of insulin and glucagon. In the present paper we have investigated, mainly with an in vivo approach, the influence and specificity of the NO synthase (NOS) blocker NG-nitro-L-arginine methyl ester (L-NAME) on L-arginine-induced

The title compound, [PdBr(C24H49P2)], has a distorted square-planar coordination geometry with the P, C, P'-tridentate ligand forming two five-membered chelate rings. The Br atom is displaced from the square plane by 0.560 (6) angstrom.

We consider the problem of finding a long, simple path in an undirected graph. We present a polynomial-time algorithm that finds a path of length Omega((log L/log log L)(2)), where L denotes the length of the longest simple path in the graph. This establishes the performance ratio O(n( log log n/log n)(2)) for the longest path problem, where n denotes the number of vertices in the graph.

Dyschondrosteosis (DCO; also called Leri-Weill syndrome) is a skeletal dysplasia characterised by disproportionate short stature because of mesomelic shortening of the limbs. Madelung deformity is a feature of DCO that is distinctive, variable in expressivity and frequently observed. Mutations of the SHOX (short stature homeobox-containing) gene have been previously described as causative in DCO.

An account of the importance of the photographic documentation of the Nazi concentration camps for the reaction to and understanding of Nazism and the Holocaust.

In this paper we analyse an extremum controller based on a pulsetechnique. The idea is to superimpose probing pulses to the controlsignal and use for feedback the size of the pulse response in the output. Theprobing control strategy has been used with success forthe control of the substrate feeding in E. coli cultivations. The analysis is done here for systems ofHammerstein type with a piecewise a

W(+)W(-)gamma production at LEP2 is studied using data collected with the DELPHI detector at centre-of-mass energies between 189 GeV and 209 GeV, corresponding to an integrated luminosity of about 600 pb(-1). Cross-sections are measured for the production of W+W- with a hard, central and isolated photon in the final state, and are found to be compatible with the Standard Model prediction. The phot