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Tumor associated neutrophils (TANs) exert dual and opposing functions in tumors, acting pro-tumorigenic and anti-tumorigenic, depending on tumor progression, polarization state and subtype. Consequently, the prognostic impact of TANs in breast cancer is also contradictory. Since neutrophils are critically needed to fight infections in cancer patients, the mediators leading to tumor progression nee

Oxy-fuel combustion is regarded as an underpinning technology for carbon capture and utilization. Ethane (C2H6) is the primary non-methane component in natural gas and a fundamental C2 fuel. In this work, laminar burning velocities (LBV) of C2H6/O2/CO2 mixtures were measured using the heat flux method at atmospheric pressure, spanning initial temperatures of 308–348 K, equivalence ratios of 0.6–1.

Background: Knee replacement (KR) is the most common osteoarthritis (OA) related surgery. Studies suggest that there are major international and national disparities in pre-operative information, support and access to rehabilitation which have a substantial impact on patients’ perceived outcomes of the KR. The aim of this qualitative study was to explore experiences and perceptions of the care pat

Background: Tumor immune cell infiltration is a favorable prognostic factor in triple-negative breast cancer. Most triple-negative tumors belong to the aggressive basal-like subtype. We hypothesized that immune gene expression may identify low-risk patients for whom adjuvant chemotherapy can be de-escalated. Methods: The expression of 753 immune-related genes was analyzed in tumor biopsies from 45

Background: Microscopic colitis (MC) is characterized by non-bloody, watery diarrhea predominantly in elderly women. Known risk factors are smoking, medication with NSAIDs, PPIs or SSRIs, while data on hormonal factors is sparse. The aim of the present study was to investigate whether hormonal factors that disrupt the sex hormonal balance could have an impact on the disease course in MC. Methods:

Background: The aim of this study was to develop a method for personalized training of Deep Neural Networks by means of an MRI simulator to improve MOLLI native T1 estimates relative to conventional fitting methods. Methods: The proposed Personalized Training Neural Network (PTNN) for T1 mapping was based on a neural network which was trained with simulated MOLLI signals generated for each individ

Animal research show that a novel exploration task performed shortly before a learning episode can strengthen hippocampal memory consolidation through behavioural tagging mechanisms. The aim of the present study was to conceptually translate behavioural tagging results to humans using a novel exploration task in virtual reality. Mimicking conditions for animal research, sixty participants underwen

Frameshifts can be caused by specific combinations of tRNA and mRNA. The wildtype AGC-decoding E. coli tRNASer3GCU has been shown to induce −1 ribosomal frameshifting on GCA alanine codons, and proposed to read a two-base codon instead of a canonical triplet. However, it has remained unclear whether this type of non-cognate decoding can be accommodated by the ribosome. Here, we perform single-part

Background: The routine use of sedation and analgesia during post-cardiac arrest care and its association with clinical outcomes remain unclear. This study aimed to describe the use of sedatives and analgesics in post-cardiac arrest care, and evaluate associations with good functional outcome, survival, clinical seizures, and late awakening. Methods: This was a post hoc analysis of the TTM2-trial,

We report on the commissioning of an ultrafast timing diagnostic for measuring a time-offset signal between two different synchronized ultrashort light pulses. The method is based on sum-frequency generation in a nonlinear crystal. The setup is similar to an auto/cross-correlator setup. In this case, one of the beams is a relatively weak diagnostic beam of visible light from a bending magnet at Fe

We theoretically investigate the properties of ultracold dipolar atoms in radially coupled, concentric annular traps created by a potential barrier. The nonrotating ground-state phases are investigated across the superfluid-supersolid phase transition, revealing a particle imbalance between the two rings and a preferential density modulation in the outer ring in the absence of rotation. Near the p

Background: For patients investigated with radiopharmaceuticals, it is important to be able to perform valid calculations of the absorbed dose in organs and tissues. An internal dosimetry computer program, IDAC-Dose2.1, has been updated to be based on the ICRP specific absorbed fractions and computational framework of internal dose assessment for 12 adult and paediatric reference individuals given

Accurate evapotranspiration (ET) estimation is vital for hydrological modeling, yet remotely sensed ET (RS-ET) products are often limited by algorithmic uncertainties and sensor biases. To mitigate error propagation and better capture spatial patterns, this study introduces the Composite Efficiency of Absolute ET and Spatial Autocorrelation (CEASA) —a dual-constraint framework that integrates abso

The enhancement of the electromagnetic field elicited by localized surface plasmon resonance (LSPR) is conducive to the generation of charge carriers, which have an important effect in driving many kinds of chemical reactions. Nonetheless, the short lifespan of charge carriers generated by plasmon (typically femtoseconds to nanoseconds) limits their effectiveness in promoting chemical reactions. H

Diverse perspectives are essential to the advancement of biodiversity science, yet persistent structural biases continue to shape who is seen and heard in academic spaces. Despite efforts to promote inclusivity, it remains unclear whether increased representation translates into equitable visibility and engagement from peers. Seminar talks, key arenas for idea exchange and networking, offer a wind

Knowledge about food structures at different length scales is key for the continued development of sustainable, tasty and healthy foods. It is critical to control, model and predict the supramolecular architecture of foods along the whole value chain: from raw materials, to their changes during processing, all the way to how products form structures during consumption and digestion. Today, advance

Background: Opioid use disorder is a chronic disorder with a high risk of overdose-related morbidity and mortality where a large proportion of these can be averted by timely administration of the antidote naloxone. For naloxone to be present when and where overdoses occur, broad-scale overdose education and naloxone distribution (OEND) must be established. A regional naloxone program was implement

Fluoride toxicity has become a significant global public health concern, with drinking water being a major source of exposure. This study aimed to determine groundwater fluoride concentration and assess its non-carcinogenic health effects on human health. A longitudinal study design was applied to select water samples in dry and wet seasons from Adama City and Wenji Gefersa town of Ethiopia. Groun

BACKGROUND: Women with intellectual disabilities face significant barriers to gynecological, reproductive, antenatal, and perinatal care, which may adversely impact maternal and fetal health. Previous research indicates increased risks for gestational diabetes, pre-eclampsia, caesarean birth, preterm birth, and other complications in pregnant women with intellectual disabilities. However, studies

The interstellar diatomic molecule, phosphorus mononitride (P≡N), is highly unstable under conditions typical on Earth, and its utility for constructing elusive P–N π-bonded motifs has remained uncertain. Here, we show how Na(OCP) transfers a P atom to an electrophilic osmium nitride complex to form a metal-bound P≡N ligand. Quantum chemical calculations and X-ray absorption spectroscopy unveil a