The dose-volume histogram (DVH) is universally used in radiation therapy for its highly efficient way of summarizing three-dimensional dose distributions. An apparent limitation that is inherent to standard histograms is the loss of spatial information, e.g. it is no longer possible to tell where low- and high-dose regions are, and whether they are connected or disjoint. Two methods for overcoming

Aims.: Literature suggests an association between loneliness and mortality for both males and females. Yet, the linkage of loneliness to mortality is not thoroughly examined, and need to be replicated with a long follow-up time. This study assessed the association between loneliness and mortality, including associations to gender, in 1363 adult swedes. Methods.: This community-based prospective co

Background: Long-term oxygen therapy (LTOT) improves prognosis in COPD with severe hypoxemia. However, adherence to criteria for eligibility and quality of LTOT is often insufficient and varies between countries. The aim of this study was to evaluate a national structure for prescription and management of LTOT over three decades in Sweden. Methods: The study was a prospective, population-based stu

OBJECTIVE: To compare access to intravenous thrombolysis (IVT) for acute ischemic stroke (AIS) and its outcomes in patients with and without dementia.METHODS: This was a longitudinal cohort study of the Swedish dementia and stroke registries. Patients with preexisting dementia who had AIS from 2010 to 2014 (n = 1,356) were compared with matched patients without dementia (n = 6,755). We examined ac

About 8000 Swedish women are diagnosed with breast cancer each year, and around 1500 die from the disease. Triple-negative breast cancer (TNBC) constitutes 7-14% of all breast cancer and is characterized by an aggressive phenotype with poor prognosis and no targeted therapy available. The aim of this thesis was to evaluate new potential prognostic biomarkers in breast cancer, and with special focu

Objectives: Occupational exposure to diesel exhaust is common due the widespread use of dieselpowered combustion engines. Diesel exhaust is chemically complex and consists of thousands of compounds present as gases and particulate matter. Both nitrogen dioxide (NO2) and elemental carbon(EC) have been used as markers for diesel exhaust exposure. Currently EC is regarded as the best surrogate of die

Housing politics is a social geographical and ideological battlefield; where housing is seen as a strategic tool and an investment object rather than an essential framework for human lifeworlds. Housing and home is the place where we meet our basic ecological and social needs. A responsible housing politics should therefore not conceive – and instrumentally use – housing as an exclusion mechanism

Searching for the errand boy: Youth jobs and social networks at the turn of the nineteenth centuryDuring the decades around 1900 increasing numbers of young men and women in Sweden worked as errand boys and girls. There are diverging ideas in the literature of what these jobs actually meant. Some scholars regard them as the starting point of a future career, others as ”dead-end jobs”. This article

Cerebrovascular disease (CVD) remains a leading cause of death and the leading cause of adult disability in most developed countries. This work summarizes state-of-the-art, and possible future, diagnostic and evaluation approaches in multiple stages of CVD, including (i) visualization of sub-clinical disease processes, (ii) acute stroke theranostics, and (iii) characterization of post-stroke recov

We review the hemodynamic, metabolic and cellular parameters affected during early ischemia and their changes as a function of approximate cerebral blood flow ( CBF) thresholds. These parameters underlie the current practical definition of an ischemic penumbra, namely metabolically affected but still viable brain tissue. Such tissue is at risk of infarction under continuing conditions of reduced C

Single ionization of helium by a superposition of selected XUV high harmonics and infrared radiation has been studied by a momentum imaging technique. The measured angular distributions of photoelectrons are compared to numerical time-dependent calculations, showing very good agreement after average. The calculated angular distributions appear to depend critically on the delay between harmonic and

Recent experimental and theoretical work examining the double photoionization of H 2 has uncovered surprising changes in the fully differential cross sections as a function of the kinetic energy released to the protons (which is equivalent to different internuclear separations of the molecule). We describe the recent joint theoretical and experimental investigations which have uncovered the physic

Photo-double ionization (PDI) of xenon by the Ti:Sapphire laser fundamental frequency combined to its 19th and 25th harmonics has been studied by means of a momentum imaging spectrometer. The measurement of the two emitted photoelectrons' momenta and their energy and angular correlations gives insight into the various mechanisms leading to PDI. Although the conditions for non-sequential direct pho

Multi-photon-double ionization of xenon by Ti:Sapphire laser pulses combined with their 25th harmonic has been studied by means of a momentum imaging spectrometer. The determination of the momenta of the emitted photoelectron pair and of its energy and angular correlation gives insight into the various mechanisms leading to double ionization. Although the conditions for non sequential direct multi

A physical interpretation is given for the variation with internuclear separation of the fully differential cross section for double photoionization of H2. This effect is analyzed in a geometry where the fourbody interaction is completely probed. Excellent agreement is found between experiment and time-dependent close-coupling theory after convoluting the latter over the relevant solid angles. We

The Coulomb explosion of the hydrogen molecule, after absorption of a 76 eV photon, has been studied by momentum imaging the two electrons and the two protons. Absolute fully differential cross sections (FDCS) are compared with Time Dependent Close Coupling (TDCC) calculations and the first-order helium-like model in the coplanar geometry for equal electron energy sharing. While the helium-like mo

Xenon multiphoton double ionization pathways are studied in a reaction microscope using a pump-probe arrangement of extreme ultraviolet high harmonic and infrared laser radiation. The momentum of photoelectrons is recorded in coincidence with singly or doubly charged ions. Among all possible routes to multiphoton double ionization, sequential processes using ionic excited states as intermediate st

The Coulomb explosion of the hydrogen molecule, after absorption of a 76eV photon, has been studied by momentum imaging the two electrons and the two protons. Absolute fully differential cross sections of high statistical quality are obtained. A subset of the overall data, namely, equal electron-energy sharing, is used to investigate the effects of molecular orientation on the photoelectron angula