Platelet-derived growth factor receptors (PDGFR) alpha and beta have been suggested as potential targets for treatment of rhabdomyosarcoma, the most common soft tissue sarcoma in children. This study identifies biologic activities linked to PDGF signaling in rhabdomyosarcoma models and human sample collections. Analysis of gene expression profiles of 101 primary human rhabdomyosarcomas revealed el

Popular Abstract in Swedish IgA-nefropati (IgAN) är den vanligaste formen av primär inflammation av njurarna och Henoch-Schönlein purpura (HSP) den vanligaste formen av kärlinflammation i barndomen. HSP kan också drabba njurarna och kallas då Henoch-Schönlein nefropati (HSN). Orsaken till båda sjukdomar är inte helt klarlagd ännu. Båda kännetecknas av vävnadsinlagringar med immunoglobulin A (IgA)IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis and Henoch-Schönlein purpura (HSP) the most common form of vasculitis in childhood. HSP may affect kidneys, a complication termed Henoch-Schönlein nephropathy (HSN). Renal pathology in HSN resembles that seen in IgAN. The pathogenesis of IgAN and HSP is so far unclear. Both are characterized by tissue deposits of undergly

Consciousness, in the beginning of its scientific use, was considered to be material, i.e., to represent an attribute of substance or matter. During later periods, it was associated with learning processes. Based on questionnaires and interviews, a number of different definitions have made its learned content dependent on statistical measures of what people consciously know. However, statically an

Conclusion: The capability of Nod1 to recognize bacteria along with its altered expression and ability to cause an immunological response in head and neck cancer suggest a novel pathway for bacteria to interfere with ongoing cancer inflammation. Objective: Nucleotide oligomerization domain (Nod)-like receptors (NLRs) comprise a recently discovered family of pattern-recognition receptors. In additi

Excited states in the N = Z - 2 nucleus (44)V have been observed for the first time. The states have been identified through particle-gamma-gamma coincidence relationships and comparison with analog states in themirror nucleus (44)Sc. Mirror energy differences have been extracted and compared to state-of-the-art shell-model calculations which include charge-symmetry-breaking forces. Observed decay

Background. The pathogenesis of cerebral ischemia after subarachnoid hemorrhage (SAH) still remains elusive. The purpose of the present study was to examine whether it is the change in intracranial pressure (ICP) or the extravasated blood that is responsible for cerebral ischemia and cerebral vasoconstriction observed following SAH. Method. Three groups of animals were studied; (1) cisternal injec

Popular Abstract in Swedish Förtroende och nationella perspektiv i multinationell krishantering: en studie av Europeiska Unionens militärstrategiska nivå Doktorsavhandling av Olof Ekman, avdelningen för Brandteknik och Riskhantering vid Lunds Tekniska Högskola (LTH), Lunds Universitet, försvarad den 9 december 2011. Tidigare forskning pekar på att förtroende i större kriser är viktigt för att saThis thesis is motivated by an increasing degree of unfamiliarity and prominence of national dimensions in multinational crisis management. The research rationale rests on the argument that trust is important but may erode when roles conflict, which in turn may result when stakeholder interests diverge. The thesis describes trust and national perspectives in terms of role conflict in an EU Operati

A procedure for guaranteed cost control design of delayed linear bilateral teleoperation systems with nonlinear external forces is proposed. The assumption that the external forces are nonlinear functions of velocities and/or positions of local devices, and one part of these forces satisfies a sector condition has been made. A virtual tool system is introduced to 'observe' the forces at the remote

An association between tumor-specific HMG-CoA reductase (HMGCR) expression and good prognosis has previously been demonstrated in breast and ovarian cancer. In this study, the expression, clinicopathological correlates and prognostic value of HMGCR expression in colorectal cancer was examined.

A fundamental role of the innate immune system is to elicit a proper response against both invading pathogens and tissue damage or danger signals. Although the innate immune system often is successful in eliminating danger, an excessive host-response can result in severe tissue injury. Factors that contribute to the elimination of the microbe are the same factors that cause tissue injury. Therefor

Reference attributed grammars (RAGs) extend Knuth’s attribute grammars with references. These references can be used to extend the abstract syntax tree to a graph. We investigate how RAGs can be used for implementing tools for visual languages. Programs in those languages can often be expressed as graphs.

Two new galloylated flavonoid glycosides, quercetin-3-O-(3 ''-O-galloyl)-beta-glucopyranoside (1) and quercetin-3-O-(3 ''-O-galloyl)-beta-galactopyranoside (2) were isolated from the aerial parts of Geranium stepporum along with the four known flavonoids, quercetin 3-O-beta-glucopyranoside (3), quercetin 3-O-beta-galactopyranoside (4), quercetin 3-O-(6 ''-O-galloyl)-beta-glucopyrinoside (5) and qu

P>Benchmarking and comparisons between transplantation centers are becoming more common. A crude comparison indicated a 50% difference in patient survival between centers in Sweden. A 'task group' was formed to refute or confirm and learn from this observation. Patient survival and graft survival of 5 933 patients transplanted at three different transplantation centers in Sweden (Stockholm, Gotebo

Objective. The aim of the study was to determine the effect of -ketoglutarate on the blood lipid profile using a rat animal model with experimentally induced hypercholesterolaemia. Material and methods. The female and male (30/30) Wistar rats had ad libitum access to a diet containing cholesterol (1 %) and lard (10 %) throughout the entire experimental period (120 days). On day 60 of the study, bo