Diamond–Blackfan anemia (DBA) results from haploinsufficiency of ribosomal protein subunits in hematopoietic progenitors in the earliest stages of committed erythropoiesis. Nemo-like kinase (NLK) is chronically hyperactivated in committed erythroid progenitors and precursors in multiple human and murine models of DBA. Inhibition of NLK activity and suppression of NLK expression both improve erythr

Background: Popliteal artery aneurysm (PAA) carries a risk of sudden thromboembolism, resulting in acute limb ischemia (ALI). Since 2010, all 65 year-old-men in Region Skåne are invited for abdominal aortic aneurysm (AAA) screening, and subsequently for PAA if AAA is detected. The aims of the study were to explore if the ratio of PAAs treated electively compared with acute has changed since the im

This scoping review addresses the role of functional limitations on evacuation performance of adults in public buildings. Although this topic has been addressed in evacuation research, no linkage is currently available between functional limitations, the predominant activities affected by them and evacuation performance. This review strives to open a debate on the need to classify the impact of di

The focus and instruments of innovation policy have changed fundamentally over the last decades. Recently transformative innovative policy has caught the attention of scholars and policy makers, arguing that this is a new shift in the policy discourse. Even though grand challenges such as global warming and migration flows, as well as technological change such as artificial intelligence and indust

In this chapter, we study the relationship between regional economic resilience and agency. Especially since the 2008 recession, regional resilience has raised a lot of interest in economic geography. However, the resilience research has focused mostly on the structural perspective and the role of agency has gained less attention. Intentional and purposeful human actions can have an effect on regi

Long bone mineralization occurs through endochondral ossification, where a cartilage template mineralizes into bone-like tissue with a hierarchical organization from the whole bone-scale down to sub-nano scale. Whereas this process has been extensively studied at the larger length scales, it remains unexplored at some of the smaller length scales. In this study, the changes in morphology, composit

We propose a methodology for studying the performance of common splitting methods through semidefinite programming. We prove tightness of the methodology and demonstrate its value by presenting two applications of it. First, we use the methodology as a tool for computerassisted proofs to prove tight analytical contraction factors for Douglas-Rachford splitting that are likely too complicated for a