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Salting the charged surface: pH and salt dependence of protein G B1 stability

This study shows signicant effects of protein surface charges on stability and these effects are not eliminated by salt screening. The stability for a variant of protein G B1 domain was studied in the pH-range of 1.5-11 at low, 0.15 M, and 2 M salt. The variant has three mutations, T2Q, N8D, and N37D, to guarantee an intact covalent chain at all pH values. The stability of the protein shows distin

Methylation of tumour suppressor gene promoters in the presence and absence of transcriptional silencing in high hyperdiploid acute lymphoblastic leukaemia

Promoter methylation is a common phenomenon in tumours, including haematological malignancies. In the present study, we investigated 36 cases of high hyperdiploid (> 50 chromosomes) acute lymphoblastic leukaemia (ALL) with methylation-specific multiplex ligase-dependent probe amplification to determine the extent of aberrant methylation in this subgroup. The analysis, which comprised the promoters

Autoantibodies and neuropsychiatric events at the time of systemic lupus erythematosus diagnosis

Objective. To examine, in an inception cohort of systemic lupus erythematosus (SLE) patients, the association between neuropsychiatric (NP) events and anti-ribosomal P (anti-P), antiphospholipid (lupus anticoagulant [LAC], anticardiolipin), anti-beta 2-glycoprotein I, and anti-NR2 glutamate receptor antibodies. Methods. NP events were identified using the American College of Rheumatology case defi

Preferences for equity in health behind a veil of ignorance

Individual attitudes to distributions of life years between two groups in a society are explored by means of an experiment. Subjects are asked to place themselves behind a veil of ignorance which is specified in terms of risk (known probabilities) for some subjects and in terms of uncertainty (unknown probabilities) for some subjects. The latter is argued to be the appropriate interpretation of Ra

Fusion of the FUS and BBF2H7 genes in low grade fibromyxoid sarcoma

The FUS gene at 16p11 fuses with DDIT3 and ATF1 as the result of translocations with chromosome band 12q13 in myxoid liposarcoma and angiomatoid fibrous histiocytoma, respectively, and with ERG as the result of a t(16;21)(p11;q22) in acute myeloid leukemia. We here show that a t(7;16)(q33;p11) in two cases of low grade fibromyxoid sarcoma fuses the FUS gene to BBF2H7, a previously uncharacterized

Environmental issues in lakes and ponds: current state and perspectives

Lakes and ponds are habitats of great human importance as they provide water for domestic, industrial and agricultural use as well as providing food. In spite of their fundamental importance to humans, freshwater systems have been severely affected by a multitude of anthropogenic disturbances, which have led to serious negative effects on the structure and function of these ecosystems. The aim of

A chiral biselectrophile for efficient asymmetric synthesis in water

The development of an efficient asymmetric dihydroxylation of 1,6-dibromodiene afforded a chiral biselectrophilic diol that displayed highly useful reactivity in water, as demonstrated by a three-step, two-pot asymmetric synthesis of a highly functionalized tetrahydrofuran.

Karyotypic analysis of two algae species Scenedesmus incrassatulus Bohl and Scenedesmus antennatus Bréb (Chlorophyta, Chlorococcales).

The karyotypes (number, morphology and size of the chromosomes) of two algae species of Scenedesmus genus, S. incrassatulus and S. antennatus, were studied. The karyotype of S. incrassatulus (n=4) was asymmetric, characterized by two large metacentric, one large submetacentric and one small metacentric chromosomes. The karyotype assembly of S. antennatus (n=6) reveals two metacentrics and four sub

DynaReP: a discrete event simulation model for re-planning of software releases

Software release planning can be described as a process consisting of the following three phases: (i) strategic release planning, i.e., the assignment of features to subsequent releases; (ii) operational release planning, i.e., the allocation of resources to tasks within each individual release; and (iii) dynamic re-planning, i.e., the revision of plans in order to handle unexpected changes impose

Time dependence of prognostic factors for patients with soft tissue sarcoma : a Scandinavian Sarcoma Group Study of 338 malignant fibrous histiocytomas

BACKGROUND: Prognostic factors for metastasis in soft tissue sarcoma govern decisions regarding adjuvant treatment. However, the significance of initial tumor-related prognostic factors over time is largely unknown.METHODS: The current study included 338 patients with malignant fibrous histiocytoma (MFH) of the extremities or the trunk wall whose tumors were reviewed by the Scandinavian Sarcoma Pa

VSC-HVDC System for Industrial Plants With Onsite Generators

Modern industrial customers, such as pulp and paper industries, have increased the vulnerability to power quality problems. A voltage source converter based high-voltage direct current (VSC-HVDC) transmission has the potential to offer high power quality when transmitting large amount of power. Therefore, in this paper, a VSC-HVDC transmission is proposed to supply such industrial plants in order

Excitonic coupling in polythiophenes: Comparison of different calculation methods

In conjugated polymers the optical excitation energy transfer is usually described as Forster-type hopping between so-called spectroscopic units. In the simplest approach using the point-dipole approximation the transfer rate is calculated based on the interaction between the transition dipoles of two spectroscopic units. In the present work we compare this approach with three others: The line-dip

Emergency obstetric care: Impact on emerging issues

Access to Emergency obstetric care (EmOC) remains a challenge for women. This paper presents a summary of issues and suggestions from one of the working groups at the FIGO precongress workshop on access of sexual and reproductive health care in November, 2006, in Kuala Lumpur.

Polarization transfer in the He-4((e)over-right-arrow,e '(p)over-right-arrow)H-3 reaction up to Q(2)=2.6 (GeV/c)(2)

We have measured the proton recoil polarization in the He-4((e) over right arrow ,e(')(p) over right arrow)H-4 reaction at Q(2)=0.5, 1.0, 1.6, and 2.6 (GeV/c)(2). The measured ratio of polarization transfer coefficients differs from a fully relativistic calculation, favoring the inclusion of a medium modification of the proton form factors predicted by a quark-meson coupling model. In addition, th

Socio-economic factors and health care system characteristics related to cancer survival in the elderly. A population-based analysis in 16 European countries (ELDCARE project)

The ELDCARE study aims to investigate, at the ecological level, the relationships between socio-economic variables and cancer survival in patients aged 65 years and over. Survival data for patients diagnosed during the period 1985-1989 and followed up to 1994 were provided by 43 European Cancer Registries in 16 countries participating in the EUROCARE 2 project. Relative survival was computed by Ha

Relating forest damage data to the wind field from high-resolution RCM simulations: Case study of Anatol striking Sweden in December 1999

Forestry is of major economical importance in Europe, and recent devastating windstorms have pinpointed the vulnerability of this economic sector to windstorms. Forest damage is an important economic issue at a country level and may become even of larger concern under future conditions following global warming. An underlying question is to what extent the storm damage is due to changes in the wind

Sources and fates of dissolved organic carbon in lakes as determined by whole-lake carbon isotope additions

Four whole- lake inorganic C-13 addition experiments were conducted in lakes of differing trophic status. Inorganic C-13 addition enriched algal carbon in C-13 and changed the delta C-13- DOC by + 1.5 parts per thousand to + 9.5 parts per thousand, depending on the specific lake. This change in delta C-13- DOC represented a significant input of algal DOC that was not completely consumed by bacteri