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Use of dietary supplements in pregnant women in relation to sociodemographic factors - a report from The Environmental Determinants of Diabetes in the Young (TEDDY) study.

OBJECTIVES: The aim of the present study was to examine the prevalence and associated factors of dietary supplement use, particularly supplements containing vitamin D and fatty acids, in pregnant women enrolled in a multi-national study. DESIGN: The Environmental Determinants of Diabetes in the Young (TEDDY) study is a prospective longitudinal cohort study. Maternal dietary supplement use was self

Variation Factors in the Design and Analysis of Replicated Controlled Experiments - Three (Dis)similar Studies on Inspections versus Unit Testing

Background. In formal experiments on software engineering, the number of factors that may impact an outcome is very high. Some factors are controlled and change by design, while others are are either unforeseen or due to chance. Aims. This paper aims to explore how context factors change in a series of for- mal experiments and to identify implications for experimentation and replication practices

Measurement of the charge asymmetry in dileptonic decays of top quark pairs in pp collisions at root s=7 TeV using the ATLAS detector

A measurement of the top-antitop (t (t) over bar) charge asymmetry is presented using data corresponding to an integrated luminosity of 4.6 fb(-1) of LHC pp collisions at a centre-of-mass energy of 7 TeV collected by the ATLAS detector. Events with two charged leptons, at least two jets and large missing transverse momentum are selected. Two observables are studied: A(C)(ll) based on the identifie

Holocene environmental changes on Nightingale Island, South Atlantic, based on diatom floristic changes in an infilled pond

A Holocene diatom stratigraphy of 2nd Pond, a small, filled pond on Nightingale Island (37 degrees 25 S, 12 degrees 29 W) was analyzed and interpreted to infer paleolimnological changes on Tristan da Cunha, South Atlantic. The diatom assemblage of 2nd Pond has the character of an acidic, oligotrophic wetland and the diatom record suggests that 2nd Pond most likely has been a bog/wetland throughout

Diverging functions among calreticulin isoforms in higher plants.

The ER chaperone calreticulin plays vital roles in numerous cellular processes, including Ca2+-homeostasis, apoptosis, and cell adhesion, in animal cells. Although calreticulin has been systematically characterized in animal cells, the focus has been on one of the isoforms. However, recent advances in the plant calreticulin field have revealed functional divergence of calreticulin isoforms. While

Several cases of work-related allergic contact dermatitis caused by isocyanates at a company manufacturing heat exchangers.

Background. A 43-year-old woman was referred by her occupational health service with suspected occupational contact dermatitis. In connection with the investigation, a workplace visit was undertaken at her company, which used an adhesive based on pre-polymeric diphenylmethane diisocyanate in one of its units. During the visit, we became aware of six other employees with skin problems who were then

Rearrangements of chromosome bands 15q12-q21 are secondary to HMGA2 deregulation in conventional lipoma.

Rearrangements of chromosome arm 15q are rare but recurrent in conventional lipomas, a tumor type often showing deregulated expression of the HMGA2 gene. In order to assess whether 15q rearrangements could constitute a distinct pathogenetic mechanism, we studied seven cases of conventional lipoma that at G-banding analysis had various rearrangements of 15q12-q21. The breakpoints in 15q were mapped

Lim Domain Binding 2: A Key Driver of Transendothelial Migration of Leukocytes and Atherosclerosis.

Using a multitissue, genome-wide gene expression approach, we recently identified a gene module linked to the extent of human atherosclerosis. This atherosclerosis module was enriched with inherited risk for coronary and carotid artery disease (CAD) and overlapped with genes in the transendothelial migration of leukocyte (TEML) pathway. Among the atherosclerosis module genes, the transcription cof

Multi-Ethnicity and Material Exchanges in Late Medieval Tallinn

This article examines the cultural and social dynamics of a multi-ethnic medieval town. Taking the lower town of Tallinn as a case study, this paper identifies the major urban ethnic groups living in the town and discusses their co-existence, self-definition, and processes of categorization. It explores ambiguities arising from daily interactions in the shared physical landscape of the town, such

Is Swollen to Tender Joint Count Ratio a New and Useful Clinical Marker for Biologic Drug Response in Rheumatoid Arthritis? Results From a Swedish Cohort

ObjectiveTo study the impact of swollen to tender joint count ratio (STR) and other baseline characteristics on treatment response to a first course of anti-tumor necrosis factor (anti-TNF) therapy in rheumatoid arthritis (RA) patients. MethodsPatients with RA initiating their first course of anti-TNF treatment were included in a structured clinical followup protocol. Based on pragmatic thresholds

DNMT3A moderates cognitive decline in subjects with mild cognitive impairment: replicated evidence from two mild cognitive impairment cohorts.

Epigenetic dysregulation has been associated with cognitive decline and Alzheimer's disease. The present study investigated associations between common SNPs in genes regulating DNA methylation and age-related changes in cognitive decline in two independent prospective cohorts of patients suffering from mild cognitive impairment. An association between the rs1187120 SNP in DNMT3A and annual decline

Trait-dependent responses of flower-visiting insects to distance to semi-natural grasslands and landscape heterogeneity

Protecting semi-natural grasslands may through spill-over benefit species richness and abundance of flower-visiting insects in linear habitats, such as uncultivated field boundaries, in agricultural landscapes. However, whether local diversity increases both with decreasing distance from potential source habitats and increasing landscape heterogeneity is poorly known due to a general lack of studi

Pressurised hot water extraction in continuous flow mode for thermolabile compounds: extraction of polyphenols in red onions.

Extraction and analysis of labile compounds in complex sample matrices, such as plants, is often a big analytical challenge. In this work, the use of a "green and clean" pressurised hot water extraction (PHWE) approach performed in continuous flow mode is explored. Experimental data for extraction and degradation kinetics of selected compounds were utilised to develop a continuous flow extraction

Distance to hospital and socioeconomic status influence secondary health care use

Objective. The aim of this study was to investigate how distance to hospital and socioeconomic status (SES) influence the use of secondary health care (SHC) when taking comorbidity into account. Design and setting. A register-based study in Ostergotland County. Subjects. The adult population of Ostergotland County. Main outcome measures. Odds of SHC use in the population and rates of SHC use by pa

Development of a pressure-measuring device to optimize compression treatment of lymphedema and evaluation of change in garment pressure with simulated wear and tear.

The use of compression garments in treating lymphedema following treatment of genital (penis, testes, uterus, cervical) and breast cancer treatment is a well-established practice. Although compression garments are classified in compression classes, little is known about the actual subgarment pressure exerted along the extremity. The aims of this study were to establish an in vitro method for measu

Electromagnetic Dispersion Modeling and Measurements for HVDC Power Cables

This paper provides a general framework for electromagnetic (EM) modeling, sensitivity analysis, computation, and measurements regarding the wave propagation characteristics of high-voltage direct-current (HVDC) power cables. The modeling is motivated by the potential use with transient analysis, partial-discharge measurements, fault localization and monitoring, and is focused on very long (10 km

A new uppermost Albian flora from Teruel province, northeastern Spain

This paper reports a new Early Cretaceous flora discovered recently near the village of Estercuel (Teruel province, northeastern Spain). The plant bearing beds belong to the uppermost part of the Early Cretaceous succession, at the top of the fluvial deposits of the Utrillas Formation. The site has yielded a diverse assemblage of plant compressions including lycopods and ferns, various gymnosperms

Real-time observation of multiexcitonic states in ultrafast singlet fission using coherent 2D electronic spectroscopy.

Singlet fission is the spin-allowed conversion of a spin-singlet exciton into a pair of spin-triplet excitons residing on neighbouring molecules. To rationalize this phenomenon, a multiexcitonic spin-zero triplet-pair state has been hypothesized as an intermediate in singlet fission. However, the nature of the intermediate states and the underlying mechanism of ultrafast fission have not been eluc