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By screening blood samples from patients with autosomal dominant retinitis pigmentosa, we found in one of the families a rhodopsin mutation (Pro-267-Leu), which segregates with the disease in two affected and five unaffected family members. Here, we present the results of the clinical evaluation of the family, including full-field electroretinography from the two affected family members. A 25-year

PURPOSE: Limited integration is consistently observed between subretinal transplants and host retinas. In the current study, an in vitro model system for studying connections forming between two abutting retinas was developed.METHODS: Neuroretinas were dissected from normal wild-type (WT) mice and green fluorescent protein (GFP) transgenic mice (obtained at postnatal days [P]0, P5, or P60), as wel

It is shown that the complete linkage clustering of n points in R-d, where d greater than or equal to 1 is a constant, can be computed in optimal O(nlogn) time and linear space, under the L-1 and L-infinity-metrics. Furthermore, for every other fixed L-t-metric, it is shown that it can be approximated within an arbitrarily small constant factor in O(nlogn) time and linear space.

The identification and quantification of 20 different polynuclear aromatic hydrocarbons (PAHs) in the fly ash from a pressurized fluidized bed (PFB) air gasification system based:on hot gas filtering were determined by GC-MS analysis. A comparison was made on the basis of the results from two different sets of experiments with varied gasifier feedstock. The first set included four experiments with

The growth of ultrathin ZrO2 films on Si(100)-(2 x 1) and Si(111)-(7 x 7) has been studied with core level photoelectron spectroscopy and X-ray absorption spectroscopy. The films were deposited sequentially by chemical vapor deposition in ultra-high vacuum using zirconium tetra-tert-butoxide as precursor. Deposition of a > 50 angstrom thick film leads in both cases to tetragonal ZrO2 (t-ZrO2), whe

Free clusters produced by a co-expansion of argon and krypton have been studied by means of core level photoelectron spectroscopy. In this study we have determined: (i) the produced clusters are heterogeneous; (ii) the radial distribution of the two atomic species in the cluster differs. The proposed structure model places the majority of the krypton atoms in the bulk, leaving the argon atoms to b

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UWB technology provides an excellent means for wireless positioning due to its high resolution capability in the time domain. Its ability to resolve multipath components makes it possible to obtain accurate location estimates without the need for complex estimation algorithms. In this article, theoretical limits for TOA estimation and TOA-based location estimation for UWB systems have been conside

We studied the energy and protein balance of a Thrush Nightingale Luscinia luscinia, a small long-distance migrant, during repeated 12-hr long Eights in a wind tunnel and during subsequent two-day fueling periods. From the energy budgets we estimated the power requirements for migratory flight in this 26 g bird at 1.91 Watts. This is low compared to flight cost estimates in birds of similar mass a

In this paper I defend against a certain objection the view that it is possible to account for validity and kindred notions for moral language within a non-cognitivist framework by appeal to the descriptive meaning of moral terms. The objection is that such an account leads to an asymmetry in the accounts it offers for synonymy in different contexts; in certain contexts it holds that sameness of m

The relationship between the two lichen species Xanthoria calcicola and X. parietina was investigated at genetic level, comparing the ITS regions of the rDNA. The extracted DNA was amplified with the primers ITS4 and ITS5 in a PCR and automatically sequenced. The variation within the separate species was smaller than the variation between the species. Compared to a third species, X. elegans, the v

The tropospheric mixing ratio profile of ethylene (C2H4) has been retrieved from a high spectral resolution ground-based infrared solar absorption spectrum. The spectrum was recorded during intense fires in New South Wales, Australia on January 1, 2002, and was analyzed with the C2H4 spectral parameters added to the 2000 HITRAN compilation. Absorption by C2H4 in the smoke-affected spectrum extends

The new heterocyclic spiro terpenoid niveulone (1) was isolated from the cultural fluid of the ascomycete Dasyscyphus niveus, and its chemical structure and relative configuration were determined by spectroscopic techniques.

Reviews the film, Requiem, directed by Hans-Christian Schmid (2006). This award-winning (for both its star, Sandra Hüller, and the film itself) German film is based on the case of Anneliese Michel, a 23-year-old German woman who died in 1976, probably of starvation (she weighed 68 lb. just before her death) and exhaustion, after 67 exorcism rites. Hüller's nuanced performance chills the spine far