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Histamine uptake by human endometrial cells expressing the organic cation transporter EMT and the vesicular monoamine transporter-2

Cellular reuptake of monoamines, which is mediated by cell membrane transporters, is followed by accumulation in vesicles by vesicular monoamine transporters (VMAT). The aim of this study was to demonstrate the presence of functional monoamine transporters with high affinity for histamine in human endometrial tissue, since histamine has been implicated as a paracrine signal during endometrial deci

Movement artefact suppression in blood perfusion measurements using a multifrequency technique

The standard way of suppressing movement artefacts in Doppler measurements is by means of a high-pass filter. This is because artefacts usually are of high amplitude, but have low frequencies. The immediate drawback is, then, that low-velocity blood flow is also filtered out. In this paper, a method to reduce movement artefacts in blood perfusion measurements is proposed, using simultaneous transm

Cyclodextrins in hydrophobically modified poly(ethylene glycol) solutions: Inhibition of polymer-polymer associations

in an aqueous solution of a hydrophobically, end-modified poly(ethylene glycol) polymer, HM-PEG, the thickening effect is dependent on intermolecular hydrophobic associations and the formation of a network structure. In the present investigation cyclodextrin, CD, has been added to an aqueous HM-PEG solution and a decrease in Newtonian viscosity has been followed. The decreased viscosity refers to

An African origin for the intimate association between humans and Helicobacter pylori

Infection of the stomach by Helicobacter pylori is ubiquitous among humans. However, although H. pylori strains from different geographic areas are associated with clear phylogeographic differentiation(1-4), the age of an association between these bacteria with humans remains highly controversial(5,6). Here we show, using sequences from a large data set of bacterial strains that, as in humans, gen

Origin of photocurrent in lateral quantum dots-in-a-well infrared photodetectors

Interband and intersubband transitions of lateral InAs/In0.15Ga0.85As dots-in-a-well quantum dot infrared photodetectors were studied in order to determine the origin of the photocurrent. The main intersubband transition contributing to the photocurrent (PC) was associated with the quantum dot ground state to the quantum well excited state transition. By a comparison between intersubband PC measur

Upregulation of Flt3 expression within the bone marrow Lin(-)Sca1(+)c-kit(+) stem cell compartment is accompanied by loss of self-renewal capacity

Flt3 has emerged as a potential regulator of hematopoietic stem cells (HSC). Sixty percent of cells in the mouse marrow Lin(-)Sca1(+)c-kit(+) HSC pool expressed flt3. Although single cell cloning showed comparable high proliferative, myeloid, B, and T cell potentials of Lin(-)Sca1(+)c-kit(+)flt3(+) and Lin(-)Sca1(+)c-kit(+)flt3(-) cells, only Lin(-)Sca1(+)c-kit(+)flt3(-) cells supported sustained

Particle-induced phase separation in mixed polymer solutions

The influence of added colloidal particles on the phase separation of mixed aqueous polymer solutions is investigated. Two types of particles (polystyrene latex or silica) and different combinations of segregating polymers (dextran of varying molar mass combined with poly(ethylene oxide) (PEO) of varying molar mass, or Ucon, a copolymer of ethylene oxide and propylene oxide) were used. All systems

In vitro effect of fibrinogen on Candida albicans germ tube formation

Pseudohyphae formation by Candida albicans blastoconidia, as seen in vaginal smears, is a phenotypical change commonly assumed to mean fungal invasiveness, i.e. not mere colonization. C. albicans forms germ tubes in vitro in the presence of serum. In our search for inhibitory components of germ tube formation, we decided to study fibrinogen. The inhibition of germ tube formation by clinical isolat

Entanglement at finite temperatures in the electronic two-particle interferometer

In this work we discuss a theory for entanglement generation, characterization and detection in fermionic two-particle interferometers (2PIs) at finite temperature. The motivation for our work is provided by the recent experiment by the Heiblum group (Neder et al 2007 Nature 448 333) realizing the two particle interferometer proposed by Samuelsson et al (2004 Phys. Rev. Lett. 92 026805). The exper

Novel polymer-polymer conjugates for recovery of lactic acid by aqueous two-phase extraction

A new family of polymer conjugates is proposed to overcome constraints in the applicability of aqueous two-phase systems for the recovery of lactic acid. Polyethylene glycol-polyethylenimine (PEI) conjugates and ethylene oxide propylene oxide-PEI (EOPO-PEI) conjugates were synthesized. Aqueous two-phase systems were generated when the conjugates were mixed with fractionated dextran or crude hydrol

Increase in muscle nociceptive substances and anaerobic metabolism in patients with trapezius myalgia: microdialysis in rest and during exercise

Local metabolic changes are suggested to be involved in muscle pain development in humans. Nineteen women with chronic work-related trapezius myalgia (TM) and 20 healthy female controls (CON) were studied during baseline rest, 20 min repetitive low-force exercise, and 120 min recovery. Interstitial serotonin (5-HT), glutamate, lactate, pyruvate, and blood flow were determined by microdialysis in t

Genetic analysis of recently identified type 2 diabetes loci in 1,638 unselected patients with type 2 diabetes and 1,858 control participants from a Norwegian population-based cohort (the HUNT study)

Aims/hypothesis Recent genome-wide association studies performed in selected patients and control participants have provided strong support for several new type 2 diabetes susceptibility loci. To get a better estimation of the true risk conferred by these novel loci, we tested a completely unselected population of type 2 diabetes patients from a Norwegian health survey (the HUNT study). Methods We

Determination of hyperfine-induced transition rates from observations of a planetary nebula

Observations of the planetary nebula NGC3918 made with the STIS instrument on the Hubble Space Telescope reveal the first unambiguous detection of a hyperfine-induced transition 2s2p P-3(0)o-->2s(2) S-1(0) in the berylliumlike emission line spectrum of N IV at 1487.89 Angstrom. A nebular model allows us to confirm a transition rate of 4x10(-4) sec(-1)+/-33% for this line. The measurement represent