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Deleterious mutations are an unavoidable part of life. In sufficiently large populations, all such mutations are removed by natural selection, though always with a concomitant loss of population fitness equal to the mutation rate. A natural question to ask is then: What happens if at another locus a rare allele appears (selectively neutral in itself) that decreases, but does not abolish, the negat
European managed grasslands are amongst the most productive in the world. Besides temperature and the amount and timing of precipitation, grass production is also highly controlled by applications of nitrogen fertilizers and land management to sustain a high productivity. Since management characteristics of pastures vary greatly across Europe, land-use intensity and their projections are critical
Micro-droplets with excellent physical properties and size effects are widely used in different fields. Peristaltic pumps are often used for droplet generation. The thrust force of pumps is periodic as a periodic disturbance when the time scale is short enough. Numerical simulation based on a validated model was applied to study the periodic disturbance effects on droplet generation in a cross-jun
En överblick över den samhällsengagerade konstren i Sverige från andra världskrigets slut till idag, avsedd för utbytesstudenter
The development of future 3D-printed electronics relies on the access to highly conductive inexpensive materials that are printable at low temperatures (<100 C). The implementation of available materials for these applications are, however, still limited by issues related to cost and printing quality. Here, we report on the simple hydrothermal growth of novel nanocomposites that are well suited fo
In the central part of the External Dinarides in Plavno, Croatia, near Knin, a remarkably thick (927.5 m) Early Triassic depositional sequence was investigated. The Plavno sequence starts in the EarlyGriesbachian and ends with a continuous transition into the Anisian strata. A complete 13C isotope curve has been achieved and combined with conodonts, bivalves and ammonoids to establish and correlat
Aims: The clinical performance of the SYNERGY drug-eluting stent (DES) in patients with acute myocardial infarction (MI) has not been investigated in detail. We sought to report on the outcomes after SYNERGY DES (Boston Scientific, Marlborough, MA, USA) implantation in patients with MI undergoing percutaneous revascularisation (PCI). Methods and results: We included all consecutive patients with M
Studies showing that large-scale public health interventions in early life have lasting consequences are still scarce and rarely disclose the mechanisms. In 1931–1946, the Swedish state reformed the childbirth institutional system that led to the openings of the new maternity wards and to the gradual decline in home deliveries assisted by midwives. Maternity wards offered improved conditions for a
Survival has improved among patients with diffuse large B-cell lymphoma (DLBCL) with the addition of anti-CD20 antibody therapy. We aimed to quantify trends and remaining loss in expectation of life (LEL) due to DLBCL at a national population-based level. Patients diagnosed with DLBCL 2000-2013 (N = 7114) were identified through the Swedish Lymphoma Registry and classified according to the age-adj
BACKGROUND: The value of arterial spin-labeling in a pediatric population has not been assessed in a meta-analysis. PURPOSE: Our aim was to assess the diagnostic accuracy of arterial spin-labeling- derived cerebral blood flow to discriminate low- and high-grade tumors. DATA SOURCES: MEDLINE, EMBASE, the Web of Science Core Collection, and the Cochrane Library were used. STUDY SELECTION: Pediatric
Hemostasis requires conversion of fibrinogen to fibrin fibers that generate a characteristic network, interact with blood cells, and initiate tissue repair. The fibrin network is porous and highly permeable, but the spatial arrangement of the external clot face is unknown. Here we show that fibrin transitioned to the blood-air interface through Langmuir film formation, producing a protective film
The Papillomaviridae is a family of small, non-enveloped viruses with double-stranded DNA genomes of 5 748 to 8 607 bp. Their classification is based on pairwise nucleotide sequence identity across the L1 open reading frame. Members of the Papillomaviridae primarily infect mucosal and keratinised epithelia, and have been isolated from fish, reptiles, birds and mammals. Despite a long co-evolutiona
The selling or procuring of sexual services was never an uncontroversial part of the everyday exchange of goods and services in Western culture. Instead, it has been represented as a problem since (at least) the Middle Ages, and the problem descriptions have had different functions as the social, economic and cultural organisation of society was changing. Men selling sex to men, on the other hand,
