Background and purpose An earlier Nordic Arthroplasty Register Association (NARA) report on 280,201 total hip replacements (THRs) based on data from 1995-2006, from Sweden, Norway, and Denmark, was published in 2009. The present study assessed THR survival according to country, based on the NARA database with the Finnish data included. Material and methods 438,733 THRs performed during the period

For the first time, various hydride phases in a zirconium-hydrogen system have been prepared in a high-energy synchrotron X-ray radiation beamline and their transformation behaviour has been studied in situ. First, the formation and dissolution of hydrides in commercially pure zirconium powder were monitored in real time during hydrogenation and dehydrogenation, then whole pattern crystal structur

The arterio-venous anastomoses (AVA) play a major role in the blood circulation in the peripheral body parts. In this work, the segmental bioheat model of Salloum et al. [1] is improved to accurately predict skin blood flow rate in the hands and fingers, and the local and overall human thermal responses in transient environments. The improvements in the model include: 1) extending the artery tree

Popular Abstract in Danish Genterapi er en attraktiv terapiform mod neurologiske lidelser som Parkinsons sygdom og epilepsi af flere grunde. Gener med en terapeutisk effekt kan introduceres lokalt ved præcise injektioner i det syge væv, hvor genproduktet kan frigives fra nerveceller i respons til aktivitet i det omgivende væv. Ved genterapi omgås den forhindring som blod-hjernebarrieren udgør, ligGene therapy is an attractive strategy for neurological disorders, such as Parkinson’s disease and epilepsy, for several reasons. Introduction of genes with a therapeutic potential can be achieved locally, by accurate injections in the compromised tissue, and release of a transgene therapeutic substance can be regulated by the surrounding host neural circuitry. The gene therapy approach circumvent

We have estimated the activation energy for aromatic oxidation by compound I in cytochrome P450 for a diverse set of 17 substrates using state-of-the-art density functional theory (B3LYP) with large basis sets. The activation energies vary from 60 to 87 kJ/mol. We then test if these results can be reproduced by computationally less demanding methods. The best methods (a B3LYP calculation of the ac

Background: With the rapid development of new genetic measurement methods, several types of genetic alterations can be quantified in a high-throughput manner. While the initial focus has been on investigating each data set separately, there is an increasing interest in studying the correlation structure between two or more data sets. Multivariate methods based on Canonical Correlation Analysis (CC

Popular Abstract in Swedish Diarré är ett vanligt symptom i befolkningen och det finns många differentialdiagnoser bakom orsaken till detta. En är inflammatorisk tarmsjukdom, något som har ökat kraftigt de senaste decennierna. Idag beräknar man att ca 1% av befolkningen har någon form av inflammatorisk tarmsjukdom och den klassas därför som en folksjukdom i Sverige. De inflammatoriska tarmsjukdomCollagenous colitis (CC) affects middle-aged women and results in chronic watery non-bloody diarrhoea. The incidence of CC has increased but has never been determined in southern Sweden. During the period 2001-2010 the mean annual incidence was stable; 5.4/105 (median age 71 years). The female: male ratio was 2.8:1, lower than in previous reports. The association between smoking and classic IBD is

Introduction: Knowledge of longitudinal progression in mild Alzheimer’s disease (AD) is required for the evaluation of disease-modifying therapies. Our aim was to observe the effects of long-term cholinesterase inhibitor (ChEI) therapy in mild AD patients in a routine clinical setting. Methods: This was a prospective, open-label, non-randomised, multicentre study of ChEI treatment (donepezil, riva

Despite its OECD membership and transformation from aid recipient into a major donor of official development assistance (ODA), Japan has long been criticized for pursuing commercial interests through its infrastructure-focused ODA, which has heavily relied on its own corporate private sector for implementation. Throughout the last two decades, institutional reforms have altered the structure and p

When selecting the least biased exposure surrogate, for example, the concentration of a biomarker in a urine sample, information on variability must be taken into consideration. We used mixed-effects models to estimate the variability and determinants of urinary cadmium (U-Cd) excretion using spot urine samples collected at six fixed times during 2 days about 1 week apart, from 24 healthy non-smok

Background: Arsenic is mono- (MMA) and dimethylated (DMA) in humans and the methylation pattern demonstrates large inter-individual differences. The fraction of urinary MMA is a marker for susceptibility to arsenic-related diseases. Objectives: The impact of polymorphisms in five methyltransferase genes on arsenic metabolism was evaluated in two populations, one in South America, one in southeast

Recently, two common sequence variants on 9p21, tagged by rs10757278-G and rs10811661-T, were reported to be associated with coronary artery disease (CAD)(1-4) and type 2 diabetes (T2D)(5-7), respectively. We proceeded to further investigate the contributions of these variants to arterial diseases and T2D. Here we report that rs10757278-G is associated with, in addition to CAD, abdominal aortic an

Conclusion: PET-CT scans seem to be sufficient to rule out residual tumour at the primary site. Patients with positive or equivocal PET findings should be scheduled for endoscopy with biopsy or a second PET-CT scan. Objectives: Assessment of remission at the primary site, in patients treated with organ preservation therapy with curative intent, is important to identify residual tumours requiring t

Abstract is not available

Brain natriuretic peptide (BNP) is normally present in low levels in the circulation, but it is elevated in parallel with the degree of congestion in heart failure subjects (CHF). BNP has natriuretic effects and is a potent vasodilator. It is suggested that BNP could be a therapeutic alternative in CHF. However, we postulated that the high levels of circulating BNP in CHF may downregulate the resp

This research programme focuses on Democracy and Public Administration, with an emphasis on making democratic institutions better fit to handle contested issues through the use of insights from Peace and Conflict Studies. We are interested in public administration’s role in addressing and (possibly) resolving contested issues and conflicts, in order to increase equality, strengthen processes of in

The mechanisms behind target vs. host cell recognition of the human antimicrobial peptide LL-37 remain ill-defined. Here, we have investigated the membrane disruption capacity of LL-37 using large unilamellar vesicles (LUVs) composed of varying mixtures of POPC, POPG and cholesterol to mimic target and host membranes respectively. We show that LL-37 is unable to induce leakage of entrapped calcein