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Background: Achondroplasia is a skeletal dysplasia with extreme, disproportionate, short stature. Aim: In a 5-y growth hormone (GH) treatment study including 1 y without treatment, we investigated growth and body proportion response in 35 children with achondroplasia. Methods: Patients were randomized to either 0.1 IU/kg (n=18) or 0.2 IU/kg (n=17) per day. GH treatment was interrupted for 12 mo af
Cross sections for the production of two isolated muons up to high di-muon masses are measured in ep collisions at HERA with the H1 detector in a data sample corresponding to an integrated luminosity of 71 pb(-1) at a centre of mass energy of roots = 319 GeV. The results are in good agreement with Standard Model predictions, the dominant process being photon-photon interactions. Additional muons o
he behaviour of a continuous-time stochastic process in the neighbourhood of zero-crossings and local maxima is compared with the behaviour of a discrete sampled version of the same process.For regular processes, with finite crossing-rate or finite rate of local extremes, the behaviour of the sampled version approaches that of the continuous one as the sampling interval tends to zero. Especially t
Neutrophil apoptosis occurs both in the bloodstream and in the tissue and is considered essential for the resolution of an inflammatory process. Here, we show that p38–mitogen-activated protein kinase (MAPK) associates to caspase-8 and caspase-3 during neutrophil apoptosis and that p38-MAPK activity, previously shown to be a survival signal in these primary cells, correlates with the levels of cas
n the current study, we address the underlying mechanism for the selective generation of gut-homing T cells in the gut-associated lymphoid tissues (GALT). We demonstrate that DCs in the GALT are unique in their capacity to establish T cell gut tropism but in vivo only confer this property to T cells in the presence of DC maturational stimuli, including toll-like receptor-dependent and -independent
The class of norm-dependent random matrix ensembles is studied in the presence of an external field. The probability density of the ensemble depends on the trace of the squared random matrices, but is otherwise arbitrary. An exact mapping to superspace is performed. A transformation formula is derived which gives the probability density in superspace as a single integral over the probability densi
In the first of two papers, the atmospheric poly brominated diphenyl ether (PBDE) concentrations at a municipal solid waste incineration (MSW) plant with electronic recycling is compared with that at an industrial urban reference site producing asphalt and concrete. In the second paper, atmospheric deposition and washout behaviour is presented (Atmos. Environ. (2004a)). PBDEs (BDE28, -47, -66, -10
In the present study, we have investigated the effects of extracellular redox status and metal/thiol interactions on glutathione distribution in HeLa cell cultures. No effects were seen on glutathione distribution after the addition of different thiols, whereas the pro-oxidant copper ions affected glutathione distribution in several ways. The addition of dithiothreitol (DTT) but not the other thio
Elongation factor G (EF-G) is a G protein factor that catalyzes the translocation step in protein synthesis on the ribosome. Its GTP conformation in the absence of the ribosome is currently unknown. We present the structure of a mutant EF-G (T84A) in complex with the non-hydrolysable GTP analogue GDPNP. The crystal structure provides a first insight into conformational changes induced in EF-G by G
The performance of poly(1-trimethylsilyl-1-propyne) (PTMSP)/silica nanocomposites was studied for membranes with a filler content between 0 and 50 wt%. An increase in permeability and a decrease in vapor selectivity was measured with increasing filler content. The free volume sizes and interstitial mesopore sizes of the composites were determined by use of positron annihilation lifetime spectrosco
The Swedish sound string /at/ (graphically: att) is associated with two grammatical functions: a) (part of) a subordinate conjunction and b) as an infinitive marker. Previous studies connect final lengthening and pauses with prosodic and syntactic boundaries in spoken discourse. Following these findings, this pilot study, with 5 short spontaneous discourses from 3 male speakers shows a correlation
We show that the smooth traveling waves of the Camassa-Holm equation naturally correspond to traveling waves of the Korteweg-de Vries equation.
Heating of 1'-(N-substituted carbamoyl)methylspiro[2H-1-benzopyran-2,2'-[2H]indoles] with potassium hydroxide in ethanol yields diastereomeric 5a,13-methano-6H-1,3-benzoxazepino[3,2-a]indole-12-carboxamides. Reduction of the latter with sodium borohydride affords 1,2,3,9a-tetrahydro-2-hydroxyaryl-9H-pyrrolo[1,2-a]indole-3-carboxamides .
Omorganisationer i form av marknadsorienterade beställar-utförarmodeller och effektivisering har sedan början av 1990-talet fått mycket stor omfattning inom offentlig sektor. De startade utan några vetenskapliga stöd för att de nya formerna skulle resultera i bättre kvalitet i tjänsterna. Resultat från en tioårig empirisk studie inom hemtjänsten pekar i stort på ingen eller negativ inverkan på arb
We report on "safe" Coulomb excitation of neutron-rich (138,140,142) Xe nuclei. The radioactive nuclei have been produced by ISOLDE at CERN and post-accelerated by the REX-ISOLDE facility. The gamma-rays emitted by the decay of excited states have been detected by the MINIBALL array. Recent results are presented.
