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ATP7B is a human copper-transporting P1B-type ATPase that is involved in copper homeostasis and resistance to platinum drugs in cancer cells. ATP7B consists of a copper-transporting core and a regulatory N-terminal tail that contains six metal-binding domains (MBD1-6) connected by linker regions. The MBDs can bind copper, which changes the dynamics of the regulatory domain and activates the protei
Akvifären Alnarpsdalen är 6 - 10 km bred och sträcker sig från Skivarp i sydost till Löddeköpinge i nordväst och vidare ut i Öresund. Trots att flertalet kommuner i Skåne numera försörjs med vatten från Vombsjön eller Bolmen finns det kommuner, industrier och jordbrukare som använder vatten från Alnarpsdalen.Det finns ett antal frågor som kan ställas gällande Alnarpsdalen, till exempel hur mycket
Background: There is growing attention and policy debate about the sharing of personal information that the modernization of electricity grids requires. This is particularly important for big data management in smart grids that needs access to data generated and sent through devices such as smart meters. Using the Nordic Countries as a case study, this study investigates the willingness of people
Tensions between migration enforcement and migrants’ health and rights have gained renewed urgency during the COVID-19 pandemic. This article critically analyses how the pandemic has affected detained and deportable people in Sweden. Building on an activist methodological approach and collaboration, based on a survey conducted inside Swedish detention centres during the pandemic and the authors’ r
The multi-electrode electrical resistivity method has become one of the most efficient geophysical methods used in a wide range of applications, which is also suitable when disturbances in the ground are to be avoided. The selection of the right electrode configuration can provide better effectiveness, depending on the target being investigated. In this work a case of the use of three electrode arThe multi-electrode electrical resistivity method has become one of the most efficient geophysical methods used in a wide range of applications, which is also suitable when disturbances in the ground are to be avoided. The selection of the right electrode configuration can provide better effectiveness, depending on the target being investigated. In this work a case of the use of three electrode ar
Background Indications with poor T-cell infiltration or deficiencies in T-cell priming and associated unresponsiveness to established immunotherapies represent an unmet medical need in oncology. CD40-targeting therapies designed to enhance antigen presentation, generate new tumor-specific T cells, and activate tumor-infiltrating myeloid cells to remodel the tumor microenvironment, represent a prom
Background: An understudied variant of Alzheimer's disease (AD), the behavioral/dysexecutive variant of AD (bvAD), is associated with progressive personality, behavior, and/or executive dysfunction and frontal atrophy. Objective: This study characterizes the neuropsychological and neuroanatomical features associated with bvAD by comparing it to behavioral variant frontotemporal dementia (bvFTD), a
Increasing tree growth and mortality rates in Europe are still poorly understood and have been attributed to a variety of drivers. This study explored the role of climate drivers, management and age structure in driving changes in tree mortality rates in six Central European countries from 1985 to 2010, using the process-based vegetation model LPJ-GUESS. Simulations show a strong positive trend in
A substantial portion of molecules in an organism are involved in regulation of a wide spectrum of biological processes. Several models have been presented for various forms of biological regulation, including gene expression regulation and physiological regulation; however, a generic model is missing. Recently a new unifying theory in biology, poikilosis, was presented. Poikilosis indicates that
Denmark is currently undertaking extensive groundwater mapping surveys in designated water interest areas. The mapping objectives include vulnerability assessments, delineation of existing aquifers, and localization of new deeper lying aquifers. Airborne electromagnetics are employed for regional mapping to depths of hundreds of meters. Resistivity profiling and pulled-array geo-electrics are utilDenmark is currently undertaking extensive groundwater mapping surveys in designated water interest areas. The mapping objectives include vulnerability assessments, delineation of existing aquifers, and localization of new deeper lying aquifers. Airborne electromagnetics are employed for regional mapping to depths of hundreds of meters. Resistivity profiling and pulled-array geo-electrics are util
Knee pain is an early sign of knee osteoarthritis (KOA) and a risk factor for chronic widespread pain (CWP). Early prevention is vital, and more research is needed to understand health-promoting activities for individuals with knee pain from a patient perspective. This study aimed to explore how individuals with knee pain experienced health-promoting activities. Explorative qualitative design with
Limited knowledge of the subsurface geology motivates the use of geophysical techniques before large engineering projects are conducted. These applications are normally restricted to satisfy the project aims, like mapping the near surface sediments, unconsolidated rocks and/or geological structures that may affect the construction locally. However, the applications can also contribute to the gener
In this work, we continue our exploration of TeV-scale vector-like fermion signatures inspired by a Grand Unification scenario based on the trinification gauge group. A particular focus is given to pair-production topologies of vector-like quarks (VLQs) at the LHC, in a multi-jet plus a charged lepton and a missing energy signature. We employ Deep Learning methods and techniques based in evolutive
In search for measures to reduce greenhouse gas emissions from transport, insights into the characteristics of all sorts of trips and specifically trips by car are needed. This paper focuses on everyday leisure trips for social and recreational purposes. Travel behaviour for these purposes is analysed considering individual and household factors as well as properties of the trip, based on Swedish
