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The location and functional properties of antigen-specific memory T-cell populations in lymphoid and nonlymphoid compartments following DNA immunization or infection with Salmonella were investigated. Epitope-specific CD8+-T-cell expansion and retention during the memory phase were analyzed for DNA-immunized mice by use of a 5-h peptide restimulation assay. These data revealed that epitope-specifi

Gastrin, released from antral G-cells, plays an important role in the regulation of gastric acid secretion and is trophic for the stomach, The cholecystokinin type 2 (CCK)(2) receptor (previously referred to as CCK-B/gastrin receptors) is expressed in both parietal cells and ECL cells in the oxyntic mucosa of stomach. Gastric phenotypic abnormality has been observed in CCK2 receptor null (gene kno

Highly efficient reversed-phase capillary electrochromatography (CEC) separations (plate numbers up to 700 000/m), with electrospray ionization mass spectrometry detection were achieved utilizing novel dextran-coated polymer nanoparticles as a pseudostationary phase. A continuous full filling (CFF) technique in which nanoparticles are continuously introduced into the capillary was employed for sep

Construction projects attract interest from various stakeholders who express needs and expectations about the project. These are often in conflict with each other and it is unlikely that all of them can be fulfilled. The stakeholder management process involves evaluating the needs and expectations of stakeholders in relation to the main objectives of the project. An important basis for this evalua

Purpose: To use velocity-encoded phase contrast (PC) MRI in assessing the effect of coronary microembolization on longitudinal and radial myocardial strain. Materials and Methods: A combined X-ray and MR system (XMR) was used for selective left anterior descending artery catheterization and microinfarct assessment in swine (n = 6). The embolized area at risk was defined on perfusion MRI followed b

osteoarthritis, risedronate, knee, bisphosphonates, cartilage

For most animals their foraging environment consists of a patch network. In random environments there are no spatial autocorrelation at all, while in fine-grained systems positive autocorrelations flip to negative ones and back again against distance. With increasing grain size the turnover rate of spatial autocorrelation slows down. Using a cellular automaton with foragers having limited informat

This paper is an attempt to understand how people, in the daily practice of interacting with material culture, created, dealt with and interpreted complex and socially stressful historical processes. A 16th-century timber-framed burgher house, the Reformation and industrialization are the focus of attention. Today the house stands in a museum of cultural history in the south Scandinavian town of L

We present exact algorithms with exponential running times for variants of n-element set cover problems, based on divide-and-conquer and on inclusion-exclusion characterisations. We show that the Exact Satisfiability problem of size 1 with m clauses can be solved in time 2(m)l(O(1)) and polynomial space. The same bounds hold for counting the number of solutions. As a special case, we can count the

Background: A major part of medical pathology in internal medicine is associated with chronic alcoholism. The aim of the current study was to investigate whether screening for Alcohol Use Disorders (AUD) can be improved through determination of direct ethanol metabolites compared to traditional biological state markers, the Alcohol Use Disorders Identification Test (AUDIT) and additional self-repo

The sulfated regions in heparan sulfate and heparin are known to affect fibroblast growth factor (FGF) function. We have studied the mechanism whereby heparin directs FGF-2-induced FGF receptor-1 (FGFR-1) signal transduction. FGF-2 alone stimulated maximal phosphorylation of Src homology domain 2 tyrosine phosphatase (SHP-2) and the adaptor molecule Crk, in heparan sulfate-deficient Chinese hamste

We consider bosonic atoms that rotate in an anharmonic trapping potential. Using numerical diagonalization of the Hamiltonian, we get evidence for various phases of the gas for different values of the coupling between the atoms and of the rotational frequency of the trap. These include vortex excitation of single and multiple quantization, the phase of center-of-mass excitation, and the unstable p

Quality of life (QoL) assessment in children with coagulation disorders is a relatively unstudied area. While hemophilia-specific questionnaires (such as Haemo-QoL) are available, no instrument for children with idiopathic thrombocytopenic purpura (ITP) has been validated yet. A disease-specific questionnaire for children with ITP was therefore developed (ITP-QoL) in three phases: (a) a preparator

Motivation: To develop tools for the submission of mutations to databases and maintenance of locus-specific mutation databases. Advanced, integrated computer systems are needed to store and organize the increasing mutation information. Results: The MUTbase program suite provides an easy, interactive and quality-controlled submission of information to mutation databases. For further study of the da

PURPOSE. To elucidate mechanisms behind the morphology of Thygeson's superficial punctate keratitis (TSPK). METHODS. Sixteen patients were examined with the slit lamp and photographed by non-contact photomicrography. The results were compared with morphology of epithelial keratitis in herpes simplex type 1 (HSV1), varicella zoster (VZV), and adenovirus type 8 (Ad8) infections, all previously studi