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Recently, the structure of protein ions in vacuo has received a lot of interest. Experimentally, such structures can only be characterized by global, low-resolution descriptors like the orientationally-averaged collision cross section (σ) over bar. An alternative descriptor of chain entanglement, the mean overcrossing number (N) over bar, is a very useful tool because it can distinguish sensitivel
Monitoring of environmental gases is necessary to understand the complex processes governing global warming and the impact of pollutant emissions related to human activity. Diode-laser-based spectroscopic techniques, being robust and affordable, have a great potential to become an industrially well-established technology for environmental sensing. This thesis deals with the further development of
Aims. We study how diffuse interstellar bands (DIBs) measured toward distance-distributed target stars can be used to locate dense interstellar (IS) clouds in the Galaxy and probe a line-of-sight (LOS) kinematical structure, a potentially useful tool when gaseous absorption lines are saturated or not available in the spectral range. Cool target stars are numerous enough for this purpose. Methods.
Context. The first release of astrometric data from Gaia is expected in 2016. It will contain the mean stellar positions and magnitudes from the first year of observations. For more than 100 000 stars in common with the HIPPARCOS Catalogue it will be possible to compute very accurate proper motions due to the time difference of about 24 years between the two missions. This Hundred Thousand Proper
Background: Epigenetic factors regulate tissue-specific expression and X-chromosome inactivation. Previous studies have identified epigenetic differences between sexes in some human tissues. However, it is unclear whether epigenetic modifications contribute to sex-specific differences in insulin secretion and metabolism. Here, we investigate the impact of sex on the genome-wide DNA methylation pat
Diabetes mellitus is a disease characterized by increased blood glucose levels. For overt type 2 diabetes to develop, both insulin action and insulin secretion must be perturbed. In the work presented in this thesis, two models were analyzed: hormone-sensitive lipase (HSL) null mice and a pancreatic clonal β-cell line to study the mechanisms underlying insulin resistance and insulin secretion pert
Land-use change is a major driver of the global loss of biodiversity, but it is unclear to what extent this also results in a loss of ecological traits. Therefore, a better understanding of how land-use change affects ecological traits is crucial for efforts to sustain functional diversity. To this end we tested whether higher species richness or taxonomic distinctness generally leads to increased
Epigenetic events have emerged as key mechanisms in the regulation of critical biological processes and in the development of a wide variety of human malignancies, including gastric cancer (GC), however precise gene targets of aberrant DNA methylation in GC remain largely unknown. Here, we have combined pyrosequencing-based quantitative analysis of DNA methylation in 98 GC cases and 64 controls ne
Abstract Ph. D. Dissertation at Göteborg University Title: en todo caso, en cualquier caso, de todos modos, de todas maneras, de todas formas. Un estudio de las características y funciones de estas locuciones en el español contemporáneo. English title: en todo caso, en cualquier caso, de todos modos, de todas maneras, de todas formas. A study of the characteristics and functions of these expressio
The main aim of this paper is to study land-atmosphere exchange of carbon dioxide (CO2) for semi-arid savanna ecosystems of the Sahel region and its response to climatic and environmental change. A subsidiary aim is to study and quantify the seasonal dynamics in light use efficiency (epsilon) being a key variable in scaling carbon fluxes from ground observations using earth observation data. The n
This study gives an outlook on the carbon balance of Sub-Saharan Africa (SSA) by presenting a summary of currently available results from the project CarboAfrica (namely net ecosystem productivity and emissions from fires, deforestation and forest degradation, by field and model estimates) supplemented by bibliographic data and compared with a new synthesis of the data from national communications
A new stratigraphy for bimodal Oligocene flood volcanism that forms the volcanic plateau of northern Yemen is presented based on detailed field observations, petrography and geochemical correlations. The > 1 km thick volcanic pile is divided into three phases of volcanism: a main basaltic stage ( 31 to 29.7 Ma), a main silicic stage ( 29.7 to 29.5 Ma), and a stage of upper bimodal volcanism ( 29.5
Popular Abstract in Swedish Interaktionen i fyra olika utvecklingssamtal från åldringsvård, industri och skola beskrivs i den här avhandlingen. Till grund ligger kritisk analys av samtalens situationella kontext, organisation och språkliga uttrycksformer. Resultaten jämförs också med hur samtalsdeltagarna själva bedömer interaktionen. Utvecklingsamtalen visar sig inte vara så ömsesidiga som de tiThis dissertation is an investigation into Swedish “utvecklingssamtal”, i.e. a kind of annual, re-curring staff development talk. The investigation consists of four empirical analyses. The first analysis concerns the situational context. The second analysis concerns the structure of the talks, the content and informal organisation. In the third analysis, I have worked quite closely to the theoreti
Purpose: Lung cancer is the worldwide leading cause of death from cancer. DNA methylation in gene promoter regions is a major mechanism of gene expression regulation that may promote tumorigenesis. However, whether clinically relevant subgroups based on DNA methylation patterns exist in lung cancer remains unclear. Experimental Design: Whole-genome DNA methylation analysis using 450K Illumina Bead
Aim. A mainstay of lymphedema management involves the use of compression therapy. Compression therapy application is variable at different levels of disease severity Evidence is scant to direct clinicians in best practice regarding compression therapy use. Further, compression clinical trials are fragmented and poorly extrapolable to the greater population. An ideal construct for conducting clinic
Background In spite of significant safety measures, allergy to industrial enzymes remains a major concern. The increasing prevalence of occupational allergy emphasizes the need to investigate the functional properties of enzyme-exposed dendritic cells (DCs), as DCs possess a potent ability to activate allergen-specific T cells. Objective This study aims at elucidating the molecular mechanisms unde
To model aerosol-cloud interactions in general circulation models (GCMs), a prognostic cloud scheme of cloud liquid water and amount is expanded to include droplet number concentration (N(d)) in a way that allows them to be calculated using the same large-scale and convective updraft velocity field. In the scheme, the evolution of droplets fully interacts with the model meteorology. An explicit tr
From 1960 to 1980 and between 1987 and 1994 the whole-body content of 17Cs, and when possible also 134Cs, was measured in a group of subjects living in the city of Lund, Sweden (55.7 degrees N, 13.2 degrees E). The results have been analyzed to estimate the effective ecological half-time of fallout radiocesium in humans living in the area. The Lund area (The Province of Skane) was subjected to a d
Objectives: A potential role in cancer biology is suggested for YKL-40 (CHI3L1, HC gp-39). The purpose of this study was to evaluate the clinical value of serum YKL-40 (sYKL-40) in multiple myeloma (MM) and to examine YKL-40 expression in malignant plasma cells (MM PCs). Methods: sYKL-40 was measured by enzyme-linked immunosorbent assay (ELISA) in 82 patients with newly diagnosed MM. YKL-40 expres
