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Introduction: Evidence-based clinical practice guidelines drive optimal patient care and facilitate access to high-quality treatment. Creating guidelines for rare diseases such as haemophilia, where evidence does not often come from randomized controlled trials but from non-randomized and well-designed observational studies and real-world data, is challenging. The methodology used for assessing av
Spray drying, a process which is widely used in the food industry, involves the atomizations of a liquid slurry into a drying chamber to produce a powder of desired properties. Although liquid viscosity strongly influences process efficiency, few studies have examined its effect on spray characteristics for specific system designs, where previous work has been hindered by experimental/numerical ch
Background: Multimorbidity is increasing globally, affecting over one-third of the population. Adults with complex needs often experience physical, mental, and cognitive disorders, leading to increased healthcare utilization, reduced quality of life, and social challenges. The frequent co-occurrence of psychiatric conditions, substance abuse, addiction, and homelessness highlights the complexity o
Background: Fetal exposure to endocrine-disrupting chemicals (EDCs) has been associated with reduced male fecundity, but with few studies considering chemical mixtures. Objectives: We assessed the association between fetal exposure to a mixture of EDCs and biomarkers of male fecundity in young adulthood. Materials and methods: The study population comprised 841 young adult males enrolled in the Fe
Interconnected societal challenges such as climate change, biodiversity loss and food security demand immediate and coordinated action across local to global scales, guided by coherent policies and management mechanisms. Reflecting on the critical need to address societal challenges, Nature-based Solutions in marine and coastal environments, known as blue NBS, have emerged as an important part of
BackgroundEndostatin is a promising biomarker for predicting acute kidney injury (AKI) and mortality in the intensive care unit (ICU). We investigated plasma endostatin levels at ICU admission as predictors of new-onset AKI within 48 h after ICU admission, renal replacement therapy (RRT) within 7 days after ICU admission, and 30-day mortality.MethodsA retrospective multicentre study was performed
Plasma p-tau217 and tau positron emission tomography (PET) are strong prognostic biomarkers in Alzheimer’s disease (AD), but their relative performance in predicting future cognitive decline among cognitively unimpaired (CU) individuals is unclear. In a head-to-head comparison study including nine cohorts and 1,474 individuals, we show that plasma p-tau217 and medial temporal lobe tau-PET signal d
Hydrogen energy technologies are forecasted to play a critical supporting role in global decarbonisation efforts, as reflected by the growth of national hydrogen energy strategies in recent years. Notably, the UK government published its Hydrogen Strategy in August 2021 to support decarbonisation targets and energy security ambitions. While establishing techno-economic feasibility for hydrogen ene
Decarbonising the global housing stock is imperative for reaching climate change targets. In the United Kingdom, hydrogen is currently being tested as a replacement fuel for natural gas, which could be used to supply low-carbon energy to parts of the country. Transitioning the residential sector towards a net-zero future will call for an inclusive understanding of consumer preferences for emerging
In an era characterised by political instability, economic uncertainty and mounting environmental pressures, hydrogen fuel is being positioned as a critical piece of the global energy security and clean energy agenda. The policy push is noteworthy in the United Kingdom, where the government is targeting industrial decarbonisation via hydrogen, while exploring a potential role for hydrogen-fuelled
BackgroundEarly identification of acute kidney injury (AKI) in the intensive care unit (ICU) remains challenging. We aimed to identify key predictors of new-onset AKI within 48 h after ICU admission and renal replacement therapy (RRT) need within 7 days, using explainable artificial intelligence (XAI) with eXtreme Gradient Boosting (XGBoost). We also assessed whether XGBoost improved predictive peBACKGROUND: Early identification of acute kidney injury (AKI) in the intensive care unit (ICU) remains challenging. We aimed to identify key predictors of new-onset AKI within 48 h after ICU admission and renal replacement therapy (RRT) need within 7 days, using explainable artificial intelligence (XAI) with eXtreme Gradient Boosting (XGBoost). We also assessed whether XGBoost improved predictive
Introduction: Retinitis pigmentosa (RP) and Leber congenital amaurosis (LCA) are two groups of inherited retinal diseases (IRDs) where the rod photoreceptors degenerate followed by the cone photoreceptors of the retina. A genetic diagnosis for IRDs is challenging since >280 genes are associated with these conditions. While whole exome sequencing (WES) is commonly used by diagnostic facilities, the
Current literature describes digital nomadism as an interesting for tourism research but a relatively exclusive social phenomenon (Chevtaeva & Denizci-Guillet, 2021; Thompson, 2019). Digital nomads are self-employed people with a mobile lifestyle made possible by digital work. Based on that description, it would seem like a research field with limited societal significance. However, the call f
The technological push for hydrogen-based steel production has become a flagship project of the Swedish state for advancing its global environmental leadership and becoming the world's first fossil free welfare state. The new production process has the potential to drastically cut emissions in a heavy polluting industry. The plans also entail a drastic upscale in steel production, energy and iron
We integrated Enviro-HIRLAM (Environment-High Resolution Limited Area Model) meteorological output into FLEXPART (FLEXible PARTicle dispersion model). A FLEXPART simulation requires meteorological input from a numerical weather prediction (NWP) model. The publicly available version of FLEXPART can utilize either ECMWF (European Centre for Medium-range Weather Forecasts) Integrated Forecast System
Conservation genomics is a rapidly growing subdiscipline of conservation biology that uses genome-wide information to inform management of biodiversity at all levels. Such efforts typically focus on species or systems of conservation interest, but rarely consider associated microbes. At least three major approaches have been used to study how microorganisms broadly contribute to conservation areas
Resulting from a combination of genetic and environmental factors, type 2 diabetes is highly heterogeneous in manifestation and disease progression, with the only common feature being chronic hyperglycaemia. In spite of vigorous efforts to elucidate the pathogenetic origins and natural course of the disease, there is still a lack of biomarkers and tools for prevention, disease stratification and t
Predictors for the pharmacological effect of ADHD medication in children and adolescents are lacking. This study examined clinically relevant factors in a large (N = 638) prospective cohort reflecting real-world evidence. Children and adolescents aged 6–17 diagnosed with ADHD were evaluated at baseline and three months following ADHD medication initiation. The outcome was measured as a reduction i
In comparison with the past, the fact that the future does not yet exist makes it a difficult object to study (von Wright 1993 ). Because of its inevitable elusiveness space is given for expectations, misgivings, and valuations (Alm 2008), but also for dreams, creativity, and imagination. Above all, the future could be seen as a potential source of change in relation to the already existing presen
