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BackgroundPrioritizing the maintenance of healthy cognitive aging and personalizing preventive interventions to enhance their effectiveness is crucial as the global population ages. Systemic inflammation and depression in older people have been associated with decreased levels of cognition but results have been inconsistent.AimsTo explore the interactive network of inflammation, depression and cog
Biologically produced wax esters can fulfil different industrial purposes. These functionalities almost drove the sperm whale to extinction from hunting. After the ban on hunting, there is a niche in the global market for biolubricants with properties similar to spermaceti. Wax esters can also serve as a mechanism for producing insect sex pheromone fatty alcohols. Pheromone-based mating disruption
The concept of food sovereignty is primarily taken as an alternative to the prevailing neoliberal food security model. However, the approach has hitherto not received adequate attention from policy makers. This could be because the discourse is marked by controversies and contradictions, particularly regarding its ability to address the challenges of feeding a rapidly growing global population. In
As the world gears up for the Net Zero carbon emissions, demand for raw materials is set to skyrocket as they are key elements of global economy and they have essential roles in improvement of life quality and the performance of manufacturing productivity. The various conventional treatment methods, including physical, chemical, and biological processes, may become outdated and may generally be re
Deep renovation of the buildings is a key for sustainable development, however, the rate of deep renovation of residential buildings in the European Union (EU) is lower than what is required to meet the climate and energy goals. This paper analyses peculiarities and commonalities in market conditions and approaches to deep renovation of single-family (or detached) houses in Denmark and Sweden. The
In times of increasing global temperatures and apathy in the face of climatic and social crises, understanding why people do or do not act is critical. Despite high pro-environmental attitudes, most people ignore the reality of climate change in their everyday lives (Moser & Kleinhückelkotten, 2017). This may be a sign for internal conflict and attempts to protect the self from threat (Norgaar
Global river systems are experiencing rapid changes in sediment transport under growing anthropogenic and climatic stresses. However, the response of sediment discharge to the coupled influence of anthropogenic and natural factors and the associated impacts on the fluvial geomorphology in the Yangtze and Mekong rivers are not comprehensively assessed. Here, we recalibrated a seamless retrieval alg
Remodelling is an important process in bones in order to maintain bone mass and to recover cracks which naturally develop within the bone material. There is agreement in the literature that the piezoelectric characteristic of bones is one possible initiator of bone remodelling. In recent experimental studies, however, it has been found that cortical bone also exhibits flexoelectric properties whic
The environmental effects of the widespread use and production of plastic have gained attention in recent years. Plastic pollution in marine environments, and limitations to systems of circularity and recycling, are increasingly recognised as serious global problems. Policies and governance around plastic are thus expected to expand in scope. This article examines the Swedish public’s opinions on
Connected autonomous vehicles can significantly improve the safety and mobility of urban transportation systems. However, these systems are vulnerable to model uncertainties, wireless communication impairments, and external disturbances. In this article, we propose a new autonomous intersection management (AIM) system, called hierarchical model predictive control (HMPC). In HMPC, the intersection
Introduction: Evidence-based clinical practice guidelines drive optimal patient care and facilitate access to high-quality treatment. Creating guidelines for rare diseases such as haemophilia, where evidence does not often come from randomized controlled trials but from non-randomized and well-designed observational studies and real-world data, is challenging. The methodology used for assessing av
Conservation genomics is a rapidly growing subdiscipline of conservation biology that uses genome-wide information to inform management of biodiversity at all levels. Such efforts typically focus on species or systems of conservation interest, but rarely consider associated microbes. At least three major approaches have been used to study how microorganisms broadly contribute to conservation areas
Resulting from a combination of genetic and environmental factors, type 2 diabetes is highly heterogeneous in manifestation and disease progression, with the only common feature being chronic hyperglycaemia. In spite of vigorous efforts to elucidate the pathogenetic origins and natural course of the disease, there is still a lack of biomarkers and tools for prevention, disease stratification and t
Background: COVID-19 caused a profound global impact, resulting in significant cases and deaths. The progression of COVID-19 clinical manifestations is influenced by a dysregulated inflammatory response. Early identification of the subclinical progression is crucial for timely intervention and improved patient outcomes. While there are various biomarkers to predict disease severity and outcomes, t
Predictors for the pharmacological effect of ADHD medication in children and adolescents are lacking. This study examined clinically relevant factors in a large (N = 638) prospective cohort reflecting real-world evidence. Children and adolescents aged 6–17 diagnosed with ADHD were evaluated at baseline and three months following ADHD medication initiation. The outcome was measured as a reduction i
Background: Exposure to polycyclic aromatic hydrocarbons (PAHs) has been associated with cardiovascular diseases in adulthood, but studies examining childhood origins are scarce. Objective: To examine associations of childhood PAH exposure with cardiometabolic risk indicators in childhood and adolescence along with differences by sex. Methods: Urinary PAH metabolites [Σ1,2,3-hydroxyphenanthrene (Σ
Interconnected societal challenges such as climate change, biodiversity loss and food security demand immediate and coordinated action across local to global scales, guided by coherent policies and management mechanisms. Reflecting on the critical need to address societal challenges, Nature-based Solutions in marine and coastal environments, known as blue NBS, have emerged as an important part of
Plasma p-tau217 and tau positron emission tomography (PET) are strong prognostic biomarkers in Alzheimer’s disease (AD), but their relative performance in predicting future cognitive decline among cognitively unimpaired (CU) individuals is unclear. In a head-to-head comparison study including nine cohorts and 1,474 individuals, we show that plasma p-tau217 and medial temporal lobe tau-PET signal d
