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BACKGROUND Advanced Therapy Medicinal Products (ATMPs) for human use have advanced globally with the rapid adoption of Chimeric Antigen Receptor T-cell (CAR-T) therapies in haemato-oncology. CAR-T cell therapy and ATMPs have unique, significant acute and chronic toxicities, and appropriate patient care is crucial. Significant challenges, including the need for nurse education and training, accompa
Road traffic accidents cause nearly 1.3 million deaths and around 50 million injuries each year globally. Most organisations generate travel and transport, and influence thereby traffic safety. In Sweden, 47 percent of fatal accidents in road traffic are work-related, and 36 percent are linked to a procured transport service. Effective approaches to managing traffic safety in organisations have no
Preemptive identification of potential failure under loading of engineering structures is a critical challenge. Our study presents an innovative approach to design built-in prefailure indicators within multiscale structural designs with optimized load carrying capabilities utilizing the design freedom of topology optimization. The indicators are engineered to visibly signal load conditions approac
Lead (Pb) is a global contaminant associated with multiple adverse health effects. Humans are especially vulnerable during critical developmental stages. During pregnancy, exposure to Pb can occur through diet and release from maternal bones. Apolipoprotein E gene (APOE) variants (ɛ2, ɛ3, ɛ4 alleles) may influence sex steroid hormones, bone metabolism, and Pb kinetics. We examined the interplay am
BACKGROUND: Accessibility to surgical services can impact earthquake preparedness and response. We aimed to estimate the population with timely access to surgical care in Guerrero, a Mexican state with high tectonic activity, and identify populations at risk in the event of an earthquake.METHODS: We conducted an ecological study using open government data. We extracted data from Guerrero municipal
Similarity measurement has been a prevailing research topic in geographic information science. Geometric similarity measurement in scaling transformation (GSM_ST) is critical to ensure spatial data quality while balancing detailed information with distinctive features. However, GSM_ST is an uncertain problem due to subjective spatial cognition, global and local concerns, and geometric complexity.
ObjectiveWe examine the impact of stepfamily exposure on the educational outcomes of children, considering factors such as age at stepfamily formation, gender of the stepparent, presence of step/half-siblings, and the stepparent's socioeconomic resources.BackgroundThe prevalence of stepfamilies across the Global North highlights the urgency of the issue. Despite a sizeable existing empirical liter
Objectives: To study the risk of osteoporosis-related fractures in a community-based sample of men and women with rheumatoid arthritis (RA) overall, as well as early (< 1 year of disease duration, follow-up time maximum 10 years) and established (RA diagnosis since ≥ 5 years on July 1, 1997) RA, compared with the general population. To study potential risk factors for fractures in patients with RA
BACKGROUND: Breast milk provides infants with complete nutrition for immune development and protection against childhood diseases and associated mortality. Early initiation of breastfeeding (EIBF) aids in providing colostrum to newborns, providing protection against infection, and improving newborn and infant survival. Although Simiyu reported the lowest prevalence of EIBF in Tanzania, no study ha
Petrochemical producers both rely upon and generate some of the most problematic substances in the current age of socioecological crisis: fossil fuels and plastics. With mounting calls to cap fossil fuel extraction as well as plastics production, the industry appears to be caught between a rock and a hard place. Nonetheless, betting on continuously increasing global plastic demand, petrochemical p
Limited knowledge of African inequality trajectories hampers our understanding of the drivers of heterogenous inequality outcomes in Africa today, and leads to major omission in debates about global inequality. In recent years, African economic history has advanced towards the reconstruction of full income distributions of African economies using 'social tables'. In this paper, we take stock of th
Background: Today, the environmental challenge presents a growing concern for the food supply chains around the world; and developing countries in particular, suffer from it. UN Global Compact has defined environmental sustainability as dealing with three main environmental challenges: climate change, water and sanitation, and food and agriculture. Digital tools have disruptive potential, especial
The Himalayan river basins offer great potential for hydropower development, but they are also vulnerable to various hazards such as debris flows, landslides, flash floods, glacial lake outburst floods (GLOFs), and landslide lake outburst floods (LLOFs). Despite the regional and global significance of these hazards, there is a lack of information and data on different aspects, including meteorolog
In this master thesis an environmental assessment is carried out for rapeseed biodiesel (RME Rape Methyl Ester) and ethanol from wheat. The assessment is done considering Swedish conditions. Both these fuels are considered for use in heavy duty vehicles. The studied environmental impact categories are: GWP (Global Warming Potential), AP (Acidification Potential), EP (Eutrophication Potential), Par
Quality Control Analysis in Real-time (QC-ART): A Tool for Real-time Quality Control Assessment of Mass Spectrometry-based Proteomics Data*□S Bryan A. Stanfill‡, Ernesto S. Nakayasu§, Lisa M. Bramer‡, Allison M. Thompson¶, Charles K. Ansong§, Therese R. Clauss§, Marina A. Gritsenko§, Matthew E. Monroe§, Ronald J. Moore§, Daniel J. Orton§, Paul D. Piehowski§, Athena A. Schepmoes§, Richard D. Smith§
Urbanization is a strongly fortified global trend. The Swedish population is increasing; however, many municipalities are faced with declining populations. Currently, regional imbalance and rural development is given more room in the social- and political debate. While rurality is often mentioned with negative emphasis, urbanity gets associated with prosperity and thus sets the norm. The region of
The expansion of Chinese media’s global influence has attracted many attentions around the world. When scholars focus on describing how the state-owned media extend beyond borders to reach audience around the globe, the long-existed Chinese diasporic media overseas are lack of discussion. How have they performed and shaped the imagination in-between China, host societies and transnational space? I
Under de två senaste decennierna har naturen som helhet och enskilda naturfenomen erkänts rättigheter i flera länder runtom i världen. I några fall har naturfenomen även fått status som juridiska personer. Uppsatsen undersöker och jämför två exempel på detta: floderna Whanganui i Nya Zeeland och Ganges och Yamuna i delstaten Uttarakhand i Indien. Uppsatsen kommer i huvudsak fram till följande: B
