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While smoking is a well-established risk factor for pancreatic cancer, the effect of smokeless tobacco is less well understood. We used pooled individual data from the Swedish Collaboration on Health Effects of Snus Use to assess the association between Swedish snus use and the risk of pancreatic cancer. A total of 424,152 male participants from nine cohort studies were followed up for risk of pan
The Arctic is warming at a rate two to three times that of the global average. Although only covering a small area of the globe, it is a vital component of the climate system. Through climatic feedback effects the warming is enhanced, and risks leading to further climate change. Simulations of future Arctic change indicate that the region will warm 3-4°C above end of 20th century levels by 2050. C
Scenarios of changes in biodiversity for the year 2100 can now be developed based on scenarios of changes in atmospheric carbon dioxide, climate, vegetation, and Land use and the known sensitivity of biodiversity to these changes. This study identified a ranking of the importance of drivers of change, a ranking of the biomes with respect to expected changes, and the major sources of uncertainties.
Growing global demand for extractive resources, such as metals and minerals, particularly to produce low-carbon products, requires international society to develop effective global governance mechanisms to mitigate some of the environmentally and socially negative impacts of mining operations beyond national borders. Since early 2000, several transnational extractive governance initiatives (TEGI)
Atmospheric vapor pressure deficit (VPD) is a key climatic factor that influences vegetation productivity and the global carbon cycle. With ongoing climate warming, VPD has been rising globally. However, the effects of this increase on gross primary production (GPP), especially under different driving mechanisms, remain unclear. This uncertainty limits our ability to predict terrestrial ecosystem
This thesis investigates the global landscape of indicators used to measure climate resilience within Water, Sanitation, and Hygiene (WASH) services through a systematic mapping and gap analysis. As climate change increasingly threatens water security and public health, there is an urgent need for theoretically grounded monitoring frameworks to evaluate systemic resilience across diverse contexts.
The relationships between polypeptide composition, sequence, structure and function have been puzzling biologists ever since first protein sequences were determined. Here, we study the statistics of occurrence of all possible pentapeptide sequences in known proteins. To compensate for the non-uniform distribution of individual amino acid residues in protein sequences, we investigate separately all
MicroRNAs (miRNA) are a group of short noncoding RNAs that regulate gene expression at the posttranscriptional level. They are involved in many biological processes, including development, differentiation, apoptosis, and carcinogenesis. Because miRNAs may play a role in the initiation and progression of cancer, they comprise a novel class of promising diagnostic and prognostic molecular markers an
Sand and dust storms (SDS) represent a significant and widespread obstacle to sustainable development, affecting its economic, social, and environmental dimensions. SDS pose severe challenges to achieving several Sustainable Development Goals (SDGs), including the eradication of poverty, the achievement of zero hunger, the improvement of health and well-being, the provision of clean water and sani
The distributions of migratory species in the ocean span local, national and international jurisdictions. Across these ecologically interconnected regions, migratory marine species interact with anthropogenic stressors throughout their lives. Migratory connectivity, the geographical linking of individuals and populations throughout their migratory cycles, influences how spatial and temporal dynami
The currently most promising approach for reducing CO2 emissions of the global steel production is reducing iron ore in shaft furnaces with (green) hydrogen instead of blast furnaces. Unlike to the liquid iron produced in blast furnaces, the direct reduced iron produced in this route (green iron) exists in a solid state and can be transported at reasonable costs over long distances. This allows fo
Only rarely is Vietnam's global heavy industry studied from an anthropological perspective in either its gender or its class dimensions. This article contributes new insights into the ways in which the interagential dynamics of gender and technology from shopfloor to engineer offices coproduce social orders in contesting and perpetuating essentializing notions of femininity and masculinity. Blue-c
Optogenetic techniques provide powerful tools for bidirectional control of neuronal activity and investigating alterations occurring in excitability disorders, such as epilepsy. In particular, the possibility to specifically activate by light-determined interneuron populations expressing channelrhodopsin-2 provides an unprecedented opportunity of exploring their contribution to physiological and p
Byggnadssektorn stod för 39 % av energi- och processrelaterade koldioxidutsläpp år 2018 och globala utsläpp från byggnader ökade med 2 % för det andra året i rad. Därför är det viktigt att ta fram lösningar på byggnadsdesign som minimerar klimatpåverkan från byggnader. Samtidigt som produktionen av bostäder och kommersiella byggnader måste vara kostnadseffektiv för att skapa boende och arbetsplatsThe building and construction sector accounted for 39% of energy and process-related carbon dioxide emissions in 2018 and global emissions from buildings increased by 2% for the second consecutive year. It is therefore important to find building design solutions that minimise the climate impact of buildings. At the same time, the production of residential houses and commercial buildings must be co
Background: Alzheimer’s disease is a progressive, irreversible, and fatal disease for which accumulation of amyloid beta is thought to play a key role in pathogenesis. Aducanumab is a human monoclonal antibody directed against aggregated soluble and insoluble forms of amyloid beta. Objectives: We evaluated the efficacy and safety of aducanumab in early Alzheimer’s disease. Design: EMERGE and ENGAG
