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To examine the association between the relaxation time (T1Gd) of delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) and grade of tibiofemoral joint space narrowing (JSN) and osteophytosis 11 years later, in a cohort of meniscectomized patients.
AZD0837 is an investigational oral anticoagulant which is converted to the active form, ARH067637, a selective direct thrombin inhibitor. The present study, a multicentre, randomised, parallel-group, dose-guiding study, assessed the safety and tolerability of an immediate-release formulation of AZD0837 compared with dose-adjusted warfarin in the prevention of stroke and systemic embolic events in
Popular Abstract in Swedish Hur slutar det? Är inte detta en fråga vi ofta vill ha besvarad? Så är åtminstone fallet i min avhandling, närmre bestämt gäller det här slutet på kromosomerna, de så kallade telomererna. Telomerer definieras som den DNA/proteinstruktur som avslutar linjära kromosomer. Gener återfinns ej i denna region vilken dock har andra viktiga funktioner. Kromosomer utan telomerer Telomeres in Chironomus consist of long complex tandem DNA repeats, which in C. pallidivittatus have been shown to extend to the extreme end of chromosomes. In C. pallidivittatus the telomeric repeats are present in large blocks, 50-200kb in size, most of them belonging to four major subfamilies. The main issue of this thesis has been to elucidate possible functional roles for these different subf
Popular Abstract in Swedish Hemolytiskt uremiskt syndrom (HUS) och trombotiskt trombocytopen purpura (TTP) är allvarliga sjukdomar hos barn och vuxna. HUS kännetecknas av mikroangiopatisk hemolytisk anemi (blodbrist med nedbrytning av röda blodkroppar), trombocytopeni (låga blodplättar) och akut njursvikt. Det är den vanligaste orsaken till akut njursvikt hos barn. Typisk HUS utlöses av tarminfektThis study investigated the pathogenesis of hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP). (1) The relative roles of lipopolysaccharide and Shiga-like toxin-2 were studied in a mouse model of Escherichia coli O157:H7 infection. Both factors were found to be important for the virulence of the strain and contributed in an additive manner. The mouse model mimicked cert
The activation of dendritic cells (DCs) by microbes is mediated by pattern recognition receptors including the Toll-like receptors (TLR). Bacterial lipopolysaccharide acts via TLR4 whereas peptidoglycan and lipoprotein responses are mediated by TLR2. It is generally accepted that TLR binding to microbes occurs at the cell surface but this has not been directly demonstrated for human DCs. We show h
The oceanographic conditions in the high-latitude North Atlantic ocean during the Holocene were reconstructed through analyses of sea surface temperature (SST; alkenone unsaturation ratios) and ice rafting (mineralogy and grain size) from two sediment sequences, one recovered from the Reykjanes Ridge at 59degreesN and the other from the Norwegian Sea at 68degreesN. Comparison of our records to pub
The effect of pressure alterations on the yield of CO2, extracts from different anatomical parts of lovage (Levisticum officinale Koch.) and celery (Apium graveolens L.) was studied. It was found that by applying frequent pressure changes in the extraction vessel it is possible to increase the rate of the isolation of CO2 soluble materials from lovage seeds and leaves, lovage and celery roots. How
Impaired serotonin transmission has been suggested to be implicated in the pathophysiology of bulimia nervosa. As an indirect measure of brain serotonergic activity, the binding of tritiated ligands to platelet serotonin transporters has been studied in bulimia nervosa as well as in other putatively serotonin-related psychiatric disorders. In this study, the density and affinity of platelet seroto
The interaction and hierarchy of celestial and magnetic compass cues used by migratory songbirds for orientation has long been the topic of an intense debate. We have previously shown that migratory Savannah sparrows, Passerculus sandwichensis, use polarized light cues near the horizon at sunrise and sunset to recalibrate their magnetic compass. Birds exposed to a +/-90 deg. shifted artificial pol
Increased QT dispersion and loss of sinus rhythm were both associated with sudden cardiac death in patients with transposition of the great arteries after Mustard and Senning operations at the early and late postoperative periods. A combination of increased QT dispersion with loss of sinus rhythm increases the positive predictive value for sudden cardiac death in patients with transposition of the
For an economically feasible production of ethanol from plant biomass by microbial cells, the fermentation of xylose is important. As xylose uptake might be a limiting step for xylose fermentation by recombinant xylose-utilizing Saccharomyces cerevisiae cells a study of xylose uptake was performed. After deletion of all of the 18 hexose-transporter genes, the ability of the cells to take up and to
Structural features of polyelectrolytes as single-stranded RNA or double-stranded DNA confined inside viral capsids and the thermodynamics of the encapsidation of the polyelectrolyte into the viral capsid have been examined for various polyelectrolyte lengths by using a coarse-grained model solved by Monte Carlo simulations. The capsid was modeled as a spherical shell with embedded charges and the
When a pinhole collimator is to be used for tomographic studies the standard SPECT software has to be modified so as to avoid serious image distortion outside the axis of rotation. The MTF measured at the axis of rotation shows that the better resolution of the pinhole collimator as compared with that of a parallel-hole collimator improves the tomographic image. The low sensitivity of the pinhole
