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Objective This study aims to investigate whether oral fluoroquinolone use is associated with an increased risk of aortic and mitral valve regurgitation. Design A nationwide cohort study based on linked healthcare register data encompassing patient characteristics, prescription data and cases of aortic and mitral valve regurgitation. Setting Sweden, 2006–2018. Participants Study participants were a
Low dimensional perovskite-inspired materials with self-tapped exciton (STE) emission have stimulated a surge of cutting-edge research in optoelectronics. Despite numerous efforts on developing versatile low-dimensional perovskite-inspired materials with efficient STE emissions, there is little emphasis on the intrinsic dynamics of STE-based broad emission in these materials. Here, we investigated
Abstract in Undetermined Background: Measured or modeled levels of outdoor air pollution are being used as proxies for individual exposure in a growing number of epidemiological studies. We studied the accuracy of such approaches, in comparison with measured individual levels, and also combined modeled levels for each subject's workplace with the levels at their residence to investigate the influe
Uppsatsens syfte är att undersöka konsumenters resonemang kring köp på internet för att öka förståelsen för vad som är viktigt för att dessa ska känna förtroende för en webbutik. En kvalitativ studie har genomförts utifrån ett hermeneutiskt förhållningssätt. Ansatsen är deduktiv med induktiva inslag. Primärdata bygger på semistrukturerade intervjuer. Sekundärdata är främst hämtad från vetenskapligThe purpose of this thesis is to examine consumer’s reasoning about online shopping to increase the understanding of what is important when it comes to trusting a webstore. A qualitative study has been conducted using a hermeneutic approach. The approach is deductive with inductive elements. Raw data is based on semistructured interviews. Secondary data is mainly taken from scientific papers. The
Populärvetenskaplig sammanfattning: Uppsatsen behandlar vegetationsutvecklingen under senholocen vid Ire i NV Blekinge. Till grund för arbetet ligger en pollenanalys från den lilla sjön Västragylet (Ire III), men två tidigare pollenanalytiska undersökningar (Ire I och II, Björkman opub, Berglund & Björkman 1999) från skogshålor i närheten tas också med. Det är i första hand kulturlandskapets uA pollen analysis has been carried out on sediments collected from the small lake Västragylet. It is situated near the village Ire in the northern part of Blekinge. The nearby river valley of Mieån constitutes an old infield area, and the lake is then situated in the outfield area. However, this part of Blekinge is not thought to have been populated on a permanent basis for more than about a thous
Popular Abstract in Swedish Hemolytiskt uremiskt syndrom (HUS) och trombotiskt trombocytopen purpura (TTP) är allvarliga sjukdomar hos barn och vuxna. HUS kännetecknas av mikroangiopatisk hemolytisk anemi (blodbrist med nedbrytning av röda blodkroppar), trombocytopeni (låga blodplättar) och akut njursvikt. Det är den vanligaste orsaken till akut njursvikt hos barn. Typisk HUS utlöses av tarminfektThis study investigated the pathogenesis of hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP). (1) The relative roles of lipopolysaccharide and Shiga-like toxin-2 were studied in a mouse model of Escherichia coli O157:H7 infection. Both factors were found to be important for the virulence of the strain and contributed in an additive manner. The mouse model mimicked cert
This paper addresses the positive synchronization of interconnected systems on undirected graphs. For homogeneous positive systems, a static feedback protocol design is proposed, based on the Linear Regulator problem. The solution to the algebraic equation associated to the stabilizing policy can be found using a linear program. Necessary and sufficient conditions on the positivity of each agent's
Background Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental condition influenced by both genetic and environmental factors. Prenatal and perinatal exposures have been implicated in ASD etiology, but their influence may vary across clinical subgroups, including subgroups defined by co-occurring intellectual disability (ID). Methods We conducted a population-based case–control st
This paper studies cone-preserving linear discrete-time switched systems whose switching is governed by an automaton. For this general system class, we present performance analysis conditions for a broadly usable performance measure. In doing so, we generalize several known results for performance and stability analysis for switched and positive switched systems, providing a unifying perspective.
Background: Prostate-specific membrane antigen positron emission tomography/computed tomography (PSMA PET/CT) enables sensitive detection and staging of prostate cancer, yet its relationship with long-term survival remains unclear. This study aimed to assess whether total lesion volume (TLV) measured on [18F]PSMA-1007 PET/CT predicts overall survival (OS) in prostate cancer patients. Methods: A co
The amyloid precursor protein intracellular domain (AICD) is an intrinsically disordered regulatory segment whose conserved YENPTY motif mediates transient interactions with multiple adaptor and signaling proteins. How sequence perturbations within this motif modulate its accessibility and interaction potential within a disordered ensemble remains poorly understood. Here, we combine small-angle X-
The proline-rich domain (PRD) of the tumor suppressor p53 plays a central role in modulating conformational dynamics and molecular interactions, yet its intrinsic structural behavior remains incompletely understood. Here, we combine extensive all-atom molecular dynamics simulations with biophysical validation to characterize the conformational ensemble of the p53 PRD. The domain behaves as an intr
Histatin 5 (Hst5) is a histidine-rich intrinsically disordered protein (IDP) whose biological function arises from a highly heterogeneous conformational ensemble and environmental sensitivity. Unlike structured antimicrobial peptides that rely on persistent secondary motifs, Hst5 remains disordered across a wide range of conditions, enabling continuous adaptation to changes in pH, ionic strength,
Background:Computed tomographic angiography (CTA) may require a non-contrast enhanced dataset for the diagnostic workup. By using dual-energy acquisition, it is possible to obtain a virtual non-contrast-enhanced (VNC) dataset, thereby possibly eliminating the non-contrast acquisition and reducing the radiation dose.Purpose:To compare image quality of VNC images reconstructed from arterial phase du
Deep learning has the potential to drastically increase the accuracy and efficiency of prostate cancer diagnosis, which would be of uttermost use. Today the diagnosis is determined manually from H&E stained specimens using a light microscope. In this paper several different approaches based on convolutional neural networks for prostate cancer classification are presented and compared, using th
