Filtyp
Study region: Trelleborg is a mid-sized coastal municipality in southern Sweden that has experienced repeated pluvial flooding in recent decades. The city comprises areas served by both combined and separate sewer systems and is increasingly exposed to intense short-duration rainfall events. This study uses 17 years (2006–2023) of property-level flood reports, in situ rainfall observations from mu
Scholars propose some new directions for researching statistical learning (SL), including the need to adopt stimuli with greater ecological validity. The language sciences are moving in these directions. Studies investigating adult SL after short exposure to an unfamiliar (spoken or signed) language show that SL can occur from richer, continuous, multimodal input, suggesting that learners are able
Climate change is intensifying short-duration rainfall extremes, increasing urban pluvial flood risk across Swedish municipalities. This study develops a novel spatial statistical framework for basement flood risk assessment using Log-Gaussian Cox Process (LGCP) models on metric graphs, applied to 17 years of flood records from Trelleborg, southern Sweden.Unlike conventional approaches that treat
Urban pluvial flooding is a growing climate-related risk in Nordic cities, where short-duration rainfall extremes interact with aging drainage infrastructure and urban form. This study analyses 17 years (2006–2023) of property-level basement flooding reports from Trelleborg, a coastal municipality in southern Sweden, to identify empirical rainfall thresholds and infrastructural conditions associat
Foraminifera are single-celled eukaryotes; most possess a perforated calcite test (shell) that fossilizes in marine sediments. During calcification, morphological features reflect environmental conditions, particularly, foraminiferal porosity is a promising proxy for reconstructing past ocean oxygenation.However, traditional analysis relies on averages from small parts of the shell in 2D slices du
Prokaryotic Argonaute proteins (pAgos) from the long-A clade are stand-alone immune systems that use small interfering DNA (siDNA) guides to recognize and cleave invading plasmid and virus DNA. Certain long-A pAgos are co-encoded with accessory proteins with unknown functions. Here, we show that cyanobacterial long-A pAgos act in conjunction with Argonaute-associated Cas4 family enzyme 1 (ACE1). S
Purpose: A multimodal artificial intelligence (MMAI) biomarker was developed using clinical trial data from North American men with localized prostate cancer treated with definitive radiation, using biopsy digital pathology images and key clinical information (age, PSA, and T-stage) to generate prognostic scores. This study externally validates the biomarker in a prospective, real-world dataset of
We propose data-driven surrogate models to solve systems of time-dependent differential equations coupled with noise. Using a feedforward neural network, we separately learn the noise and solution, tackling approximations across regimes with bifurcations and rare events. Focusing on irregular data generated by a stochastic noise model on a one-dimensional spatial lattice coupled to a differential
Background and objective: Prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) is an evolving diagnostic tool for prostate cancer. There is a need to harmonise existing guidelines and reporting recommendations for PSMA PET/CT. The Standardised PSMA PET/CT Analysis and Reporting Consensus (SPARC) project aims to consolidate classifications and recommen
Power required to fly for a bird generally follows a U-shaped function of airspeed, with higher cost at both low and high speeds. Because power required increases with body mass faster than power available from flight muscles, larger birds may experience restricted flight speed ranges and climbing capabilities. Previous studies found limited flight performance in cormorants. Adapted for both fligh
Marine megafauna species are affected by a wide range of anthropogenic threats. To evaluate the risk of such threats, species’ vulnerability to each threat must first be determined. We build on the existing threats classification scheme and ranking system of the International Union for Conservation of Nature (IUCN) Red List of Threatened Species by assessing the vulnerability of 256 marine megafau
Purpose: Cardiac diffusion tensor imaging (cDTI) can investigate the microstructure of heart tissue. At sufficiently high b-values, additional information on microstructure can be observed, but the data require a representation such as diffusion kurtosis imaging (DKI). cDTI is prone to image corruption, which is usually treated with shot rejection but which can be handled more generally with robus
Background and objective: Although cardiovascular toxicity from modern systemic treatments in metastatic hormone-sensitive prostate cancer (mHSPC) remains a concern, real-world data are limited. We aimed to characterise patients treated for mHSPC across multiple large cohorts and estimate cardiovascular adverse event (AE) risks. Methods: Leveraging PIONEER's Big Data platform, with databases stand
The perivascular space (PVS) is integral to glymphatic function, facilitating fluid exchange and waste clearance in the brain. Diffusion tensor imaging along the perivascular space (DTI-ALPS) has been proposed as a noninvasive marker of perivascular diffusion, yet its specificity remains unclear. ALPS measures assume radial symmetry in white matter (characterized by equal transverse diffusion eige
Tropical cyclones (TCs) pose significant threats to life and property across global ocean basins, and forecasting their structural evolution, track, and intensity remains a major scientific challenge. This review synthesizes the current understanding of TCs across major basins, that is, the Pacific, Atlantic, and North Indian Oceans, with a focus on the key environmental factors influencing TC beh
Background and Aims. While the rationale for coronavirus disease 2019 (COVID-19) vaccination is to reduce complications and overall mortality, some cardiovascular complications from the vaccine itself have been demonstrated. Myocarditis and pericarditis are recognized as rare acute adverse events after mRNA vaccines in young males, while evidence regarding other cardiovascular events remains limit
Traits that affect organismal fitness are often highly genetically variable. This genetic variation is vital for populations to adapt to their environments, but it is also surprising given that nature – after all – ‘selects’ the best genotypes at the expense of those that fall short. Explaining the extensive genetic variation of fitness-related traits is thus a longstanding puzzle in evolutionary
Introduction: This study evaluated real-world cassette use and cost of levodopa-carbidopa intestinal gel (LCIG; 2000 mg levodopa equivalent dose [LED]) and levodopa-entacapone-carbidopa intestinal gel (LECIG; 1250 mg LED) pump treatments among patients with advanced Parkinson’s disease (PD) in Sweden. Methods: This was a non-interventional, longitudinal, retrospective, comparative study of patient
