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There exist several datasets for developing self-driving car methodologies. Manually collected datasets impose inherent limitations on the variability of test cases and it is particularly difficult to acquire challenging scenarios, e.g. ones involving collisions with pedestrians. A way to alleviate this is to consider automatic generation of safety-critical scenarios for autonomous vehicle (AV) te
Intrinsically disordered proteins (IDPs) have a broad energy landscape and consequently sample many different conformations in solution. The innate flexibility of IDPs is exploited in their biological function, and in many instances allows a single IDP to regulate a range of processes in vivo. Due to their highly flexible nature, characterizing the structural properties of IDPs is not straightforw
The phase gradient autofocus (PGA) is a robust autofocusing approach that can efficiently refocus defocused synthetic aperture radar (SAR) imagery produced by frequency-domain algorithms. However, from a conventional viewpoint, PGA cannot be extended to refocus SAR imagery produced by time-domain algorithms, such as the filtered backprojection (FBP), as the spectrum of the FBP imagery is range amb
Background: Radical prostatectomy reduces mortality among patients with localised prostate cancer. Evidence on whether different surgical techniques can affect mortality rates is lacking. Objective: To evaluate functional and oncological outcomes 8 yr after robot-assisted laparoscopic prostatectomy (RALP) and open retropubic radical prostatectomy (RRP). Design, setting, and participants: We enroll
Resonant photoelectron spectroscopy (RPES) has been used to probe electronic structure properties of the closed-shell [FeII(CN)6]4− and open-shell [FeIII(CN)6]3− prototype transition metal complexes in aqueous solution. Site-selective Fe 2p (L-edge) RPES mapsprovide new insight into spin-coupling processes at the core-excited metal centers, with autoionization of [FeIII(CN)6]3− showing a dramatic
Rank and cardinality penalties are hard to handle in optimization frameworks due to non-convexity and discontinuity. Strong approximations have been a subject of intense study and numerous formulations have been proposed. Most of these can be described as separable, meaning that they apply a penalty to each element (or singular value) based on size, without considering the joint distribution. In t
For diagnosis and risk assessment in patients with stable ischemic heart disease, myocardial perfusion scintigraphy is one of the most common cardiological examinations performed today. There are however many motivations for why an artificial intelligence algorithm would provide useful input to this task. For example to reduce the subjectiveness and save time for the nuclear medicine physicians wo
Aims/hypothesis: Sleep, diet and exercise are fundamental to metabolic homeostasis. In this secondary analysis of a repeated measures, nutritional intervention study, we tested whether an individual’s sleep quality, duration and timing impact glycaemic response to a breakfast meal the following morning. Methods: Healthy adults’ data (N = 953 [41% twins]) were analysed from the PREDICT dietary inte
Amyloid fibrils are associated with a number of neurodegenerative diseases, including fibrils of amyloid β42 peptide (Aβ42) in Alzheimer's disease. These fibrils are a source of toxicity to neuronal cells through surface-catalyzed generation of toxic oligomers. Detailed knowledge of the fibril structure may thus facilitate therapeutic development. We use small-angle scattering to provide informati
Atmospheric inversion approaches are expected to play a critical role in future observation-based monitoring systems for surface fluxes of greenhouse gases (GHGs), pollutants and other trace gases. In the past decade, the research community has developed various inversion software, mainly using variational or ensemble Bayesian optimization methods, with various assumptions on uncertainty structure
Reliable quantification of the sources and sinks of atmospheric carbon dioxide (CO2), including that of their trends and uncertainties, is essential to monitoring the progress in mitigating anthropogenic emissions under the Kyoto Protocol and the Paris Agreement. This study provides a consolidated synthesis of estimates for all anthropogenic and natural sources and sinks of CO2 for the European Un
Background Previous studies of minimally invasive liver surgery described results and experiences in high-volume centres and early adopters, but data on national levels are lacking. This study evaluated the implementation and outcomes of minimally invasive liver surgery in Sweden over a 15-year period, with a focus on colorectal liver metastases. Methods Data from patients undergoing liver surgery
Purpose Gangliogliomas are highly epileptogenic tumors that are common in epilepsy surgery. The main aim of this study was to investigate whether the outcome of Anti-seizure medication (ASM) withdrawal differed between patients undergoing ganglioglioma surgery in an epilepsy surgery program compared with those who underwent surgery in other surgical programs. We also investigated which factors inf
Visual assessment of medial temporal lobe atrophy (MTA) in the clinical workup of cognitive impairment is traditionally corrected for age since MTA increases with age. In addition, common pathologies in the elderly such as amyloid, tau, alpha-synuclein and TDP-43 accumulation as well as white matter hyperintensities representing small vessel disease may affect the association between MTA and age.
The development of acid-stable, non-precious catalysts for the oxygen evolution reaction (OER) remains a critical challenge for proton exchange membrane water electrolyzers (PEMWEs). While Co3O4 shows promising OER activity, its rapid dissolution in acidic media severely limits practical application. Here, we design a self-adaptive protection strategy by depositing ZrN coatings on Co3O4 precursor
Introduction: It is well known that urinary tract infection (UTI) during pregnancy is associated with preterm birth, but information about the risk of preterm birth depending on gestational week of infection is sparingly described in the literature. Material and Methods: An observational study based on data from Swedish registers including women giving birth 2014–2020 (n = 684 595). Pregnant women
Introduction: Vaginal Natural Orifice Transluminal Endoscopic Surgery (vNOTES) is a technique combining vaginal entrance to the abdomen with endoscopic overview. Previous studies have shown that vNOTES decreases operating time, hospitalization, postoperative complications, and pain. We aimed to present patient demographics, costs, and surgical outcomes following the implementation of vNOTES for be
In an era of global migration, where public discourse often assumes that migrants lack exposure to and command of local majority language(s), it is a crucial research task to understand how migrants learn and use new languages in their everyday lives. This study provides empirical evidence about the quantity and nature of everyday language exposure and use (LEU) among migrants in Sweden. Using the
Long RSH enzymes, Rel and RelA, are master regulators of bacterial (p)ppGpp alarmones levels. Bifunctional Rel transitions between a compact hydrolysis-competent (HD ON) state, a relaxed catalytically inactive (HD OFF/SYNTH OFF) state, and an elongated synthesis-competent (SYNTH ON) state, whereas RelA samples only the latter two. The distribution of these states is controlled by starved ribos
