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Several studies suggest that the apolipoprotein E (APOE) ε4 allele modulates cerebrospinal fluid (CSF) levels of β-amyloid 42 (Aβ42). Whether this effect is secondary to the association of the APOE ε4 allele with cortical Aβ deposition or whether APOE ε4 directly influences CSF levels of Aβ42 independently of Aβ pathology remains unknown.
The race to publish results during the outbreak of the new coronavirus (SARS-CoV-2) has highlighted the relevance of sharing data and research results more quickly and openly than the current scientific communication system, as well as the role of social media in this context. This paper aims to analyze the impact of open access on the production and dissemination of knowledge about COVID-19 in tr
Abstract Background: Total plasma homocysteine (tHcy) concentration is increased in elderly patients with mental illness. Also, patients with vascular disease have significantly higher plasma tHcy concentration compared with patients without vascular disease. Apolipoprotein E (apoE) status is associated with cardiovascular disease and a major genetic risk factor is inheritance of the e4 allele. In
BACKGROUND: Expansion of type 2 innate lymphoid cells (ILC2s) in hypercholesterolaemic mice protects against atherosclerosis while different ILC2 subsets have been described (natural, inflammatory) based on their suppression of tumorigenicity 2 (ST2) and killer-cell lectin like receptor G1 (KLRG1) expression. The aim of the current study is to characterize the interleukin 25 (IL25)-induced splenic
The objective of this study is to point out an effective alternative in the treatment of the cranial and caudal cruciate ligaments rupture in dogs, with no association of external immobilization. Six dogs with rupture of both cruciate ligaments were included in the present study. Stifle joint was surgically stabilized by an intracapsular technique, using two polypropylene synthetic implants. The a
A total synthesis of transtaganolide E and F, proposed intermediates in the biosynthesis of the potent transtaganolides, including an Ireland-Claisen rearrangement and a high-pressure intramolecular Diels-Alder cycloaddition reaction of an unactivated 2-pyrone derivative, is reported. The implication of the results to the proposed transtaganolides biosynthesis is discussed.
Background Patients with severe asthma are often inadequately controlled on existing anti-asthma therapy, constituting an unmet clinical need. Objective This randomized, double-blind, placebo-controlled trial evaluated the ability of omalizumab, a humanized monoclonal anti-IgE antibody, to improve disease control sufficiently to enable inhaled corticosteroid reduction in patients with severe aller
The pre-Talpha (pTalpha[?]) gene encodes a protein that forms the pre-TCR together with the newly expressed TCR beta chain during a defined stage of early T cell development. The restricted expression of this gene has been suggested to depend on a promoter and an enhancer element containing E boxes, which are potential binding sites for basic helix-loop-helix (bHLH) proteins. We here report that i
Biografisk skildring av Sven Rydberg (1789-1865), jurist, filosof, språkman, historiker och bibliotekarie, med fokus på det faktum att han trots omvittnad vittomfattande begåvning aldrig lyckades göra akademisk karriär.
The work of Beppe Fenoglio, a well-known Italian writer, has increased in popularity in the 90s, more than 30 years after his death. As a reaction to the change in the Italian political scene with the entry of the neo fascist party in the government in the 90s, the new generation felt a need to defend the democratic ideals; this might explain the rediscovery the works of Fenoglio where the partisa
This thesis attends to vulnerability and precarity within visual representation by analysing the negative affects bound to the experience of social exclusion. The study explores what it might mean to embrace and not overcome 'bad feelings' like shame and alienation using the visual example of an elderly prostitute–a ‘Bacchus Lady’– in E J-yong's 2016 film The Bacchus Lady. Investigatin
