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Popular Abstract in Swedish Bröstcancer är den vanligast förekommande cancerformen hos kvinnor och årligen drabbas ungefär 6000 kvinnor i Sverige. I de flesta fall uppstår bröstcancer spontant, men viss ärftlighet ligger bakom ca 10 % fallen. Det finns kopplingar till faktorer som ökar risken för bröstcancer. Till riskfaktorer hör bl.a. långvarig exponering för hormoner: tidig mens och sent klimakUnrestrained proliferation is a hallmark of cancer and genetic defects within G1/S-phase regulation and the pRb pathway occur frequently. Proliferation control can be circumvented either by excess cyclin D1 or cyclin E, alterations that can define two alternative tumour biologic pathways in breast cancer. By overexpressing cyclin E in a cell line model system we demonstrate that the capacity of ce

Synaptic changes and neuronal network dysfunction are among the earliest changes in Alzheimer’s disease (AD). Apolipoprotein E4 (ApoE4), the major genetic risk factor in AD, has been shown to be present at synapses and to induce hyperexcitability in mouse knock-in brain regions vulnerable to AD. ApoE in the brain is mainly generated by astrocytes, however, neurons can also produce ApoE under stres

Context. 55 Cnc e is a transiting super-Earth (radius 1.88 R⊕ and mass 8 M⊕) orbiting a G8V host star on a 17-h orbit. Spitzer observations of the planet's phase curve at 4.5 μm revealed a time-varying occultation depth, and MOST optical observations are consistent with a time-varying phase curve amplitude and phase offset of maximum light. Both broadband and high-resolution spectroscopic analyses

This paper describes the performance evaluation of new Delta E detectors to be used as pre-cell hit detectors in living cell irradiation experiments at the Lund Ion Beam Analysis facility (LIBAF). Using these detectors with a thickness down to 4.15 mu m fabricated at Lund University, an experiment was setup in which Delta E-detectors were used together with a stop E-detector in a telescope system

The paper’s title evokes a conversation; in fact it has been constructed like a joint revisitation of Bianca Beccalli’s forty years work on labour, gender, and politics, reconsidering old challenges and facing emergent ones. The paper deals with two levels of analysis: a historical and sociological interpretation of social movements, work, and politics on the one side, while dealing on the other s

Abstract in ItalianNel 2017 Dennis C. Rasmussen ha pubblicato The Infidel and the Professor: David Hume, Adam Smith, and the Friend-ship that Shaped Modern Thought (Princeton-Oxford, Princeton University Press). Si tratta di uno studio destinato a suscitare un vivace dibattito sia per quel che concerne la re-visione dell’immagine canonica dei due filosofi, sia per le implicazioni teoriche ad essa

The thesis, moving from several critical points of the Italian industrial relation system, studies in which way the rules that regulate those systems can influence the competitiveness of the enterprises. For this scope are compared several European experiences such as the Italian, Spanish and French ones, with particular attention to the changes that have been put in place after the 2008 economic

Starting from the renewed interest in the enforceability of collective agreements brought by the so-called Fiat case, this essay examines the instruments introduced by collective bargaining to this end, studying their nature in both legal and economic terms. Lastly, it proposes several interventions — to be adopted through both a legislative and a collective-bargaining process — aimed at ensuring

Monte Carlo models of DIS e-gamma scattering must describe hard emissions as well as the soft and collinear limits. Comparison with the observed experimental hadronic energy flow has shown that various models underestimate the high-p_T contribution, in particular at low-x. We have attempted to tune the Herwig, Pythia and Ariadne models to improve the agreement with the data, and to understand the

Per oltre quarant’anni, la scrittura della storia nei paesi dell’Europa orientaleè stata fortemente condizionata dagli imperativi ideologici e propagandisticidei regimi comunisti. La storia, più di ogni altra disciplina umanistica, offrivagiustifi cazioni, e quindi legittimità, al potere. Indagare il rapporto tra storia epotere in questo ambito signifi ca tanto addentrarsi nella storia dei sociali