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Background: Childhood cancer survivors are at risk of subsequent primary soft-tissue sarcomas (STS), but the risks of specific STS histological subtypes are unknown. We quantified the risk of STS histological subtypes after specific types of childhood cancer.Methods: We pooled data from 13 European cohorts, yielding a cohort of 69 460 five-year survivors of childhood cancer. Standardized incidence
At the time of cancer diagnosis, body mass index (BMI) is inversely correlated with lung cancer risk, which may reflect reverse causality and confounding due to smoking behavior. We used two-sample univariable and multivariable Mendelian randomization (MR) to estimate causal relationships of BMI and smoking behaviors on lung cancer and histological subtypes based on an aggregated genome-wide assoc
Lymphotoxin β-receptor (LTβR) signalling promotes lymphoid neogenesis and the development of tertiary lymphoid structures1,2, which are associated with severe chronic inflammatory diseases that span several organ systems3-6. How LTβR signalling drives chronic tissue damage particularly in the lung, the mechanism(s) that regulate this process, and whether LTβR blockade might be of therapeutic value
Breast cancer susceptibility variants frequently show heterogeneity in associations by tumor subtype1-3. To identify novel loci, we performed a genome-wide association study including 133,384 breast cancer cases and 113,789 controls, plus 18,908 BRCA1 mutation carriers (9,414 with breast cancer) of European ancestry, using both standard and novel methodologies that account for underlying tumor het
Background: An early report on the molecular subtyping of muscle-invasive bladder cancer (MIBC) by gene expression suggested that response to neoadjuvant chemotherapy (NAC) varies by subtype. Objective: To investigate the ability of molecular subtypes to predict pathological downstaging and survival after NAC. Design, setting, and participants: Whole transcriptome profiling was performed on pre-NA
Using data from a genome-wide association study of 907 individuals with childhood acute lymphoblastic leukemia (cases) and 2,398 controls and with validation in samples totaling 2,386 cases and 2,419 controls, we have shown that common variation at 9p21.3 (rs3731217, intron 1 of CDKN2A) influences acute lymphoblastic leukemia risk (odds ratio = 0.71, P = 3.01 x 10(-11)), irrespective of cell linea
Background We previously showed that the BRCA1 variant c.5096G>A p.Arg1699Gln (R1699Q) was associated with an intermediate risk of breast cancer (BC) and ovarian cancer (OC). This study aimed to assess these cancer risks for R1699Q carriers in a larger cohort, including follow-up of previously studied families, to further define cancer risks and to propose adjusted clinical management of female BR
RATIONALE: Vascular calcification is a prominent feature of late-stage diabetes, renal and cardiovascular disease (CVD), and has been linked to adverse events. Recent studies in patients reported that plasma levels of osteomodulin (OMD), a proteoglycan involved in bone mineralisation, associate with diabetes and CVD. We hypothesised that OMD could be implicated in these diseases via vascular calci
BACKGROUND: Complement activation may promote atherosclerosis. Yet, data on the to which extent complement, and more specifically the alternative complement pathway, is activated in patients with carotid atherosclerosis and related to adverse outcome in these patients, are scarce.METHODS AND RESULTS: We measured, by ELISA, plasma levels of factor D, properdin, C3bBbP (C3 convertase), and factor H
Subcellular membrane systems are highly enriched in dolichol, whose role in organelle homeostasis and endosomal-lysosomal pathway remains largely unclear besides being involved in protein glycosylation. DHDDS encodes for the catalytic subunit (DHDDS) of the enzyme cis-prenyltransferase (cis-PTase), involved in dolichol biosynthesis and dolichol-dependent protein glycosylation in the endoplasmic re
The medial temporal lobe (MTL) cortex, located adjacent to the hippocampus, is crucial for memory and prone to the accumulation of certain neuropathologies such as Alzheimer's disease neurofibrillary tau tangles. The MTL cortex is composed of several subregions which differ in their functional and cytoarchitectonic features. As neuroanatomical schools rely on different cytoarchitectonic definition
The Warburg effect is ubiquitous in proliferative mammalian cells, including cancer cells, but poses challenges for biopharmaceutical production, as lactate accumulation inhibits cell growth and protein production. Previous efforts to eliminate lactate production via knockout have failed in mammalian bioprocessing since lactate dehydrogenase has proven essential. However, here we eliminated the Wa
Riktlinjer_datormiljö_HT_2017, final Postadress Box 201, 221 00 Lund Besöksadress Helgonabacken 12, 223 62 Lund Telefon 046-222 32 25, 046-222 00 00 Webbadress www.ht.lu.se/person/BirgittaLastow Faku l te tss ty re lsens arbe tsu tsko tt Riktlinjer för anställdas IT-miljö inom Humanistiska och teologiska fakulteterna Anställda1 inom HT2 vid Lunds universitet ska ha en IT-miljö som tillåter dem att
https://www.ht.lu.se/fileadmin/user_upload/ht/dokument/Fakulteterna/policydok_planer/Riktlinjer_itmiljoe_HT_2017.pdf - 2026-05-30
Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and shape change as people grow older and these changes differ substantially between men and women. To systematically screen for age- and/or sex-specific effects of genetic variants
Arbete och försörjning Seminarieprogram VT 2026 Seminariet sker i samarbete mellan ämnena historia och ekonomisk historia och har två aktiviteter: längre presentationsseminarier med inbjudna gäster (tisdagar) och kortare diskussionsseminarier av texter under arbete (fredagar). Seminariespråk är vanligen svenska, med engelska på vissa seminarier (det anges då i utskicket). Tisdag 20 januari, 13.15–
Var lämnar jag in min avhandling? - FAQ Hoppa till nästa fråga Lund University Libraries FAQ varning: Din webbläsare har javascript inaktiverat. Utan javascript kommer vissa funktioner inte att fungera, inklusive inlämning av frågor via formuläret. Q. Var lämnar jag in min avhandling? Toggle menu visibility Ställ en ny fråga Sök Bläddra: Visa alla Språk English Svenska Ändra ämne 5 Avhandlingar oc
https://libanswers.lub.lu.se/faq/109296 - 2026-05-23
Har biblioteken dagstidningar? - FAQ Hoppa till nästa fråga Lund University Libraries FAQ varning: Din webbläsare har javascript inaktiverat. Utan javascript kommer vissa funktioner inte att fungera, inklusive inlämning av frågor via formuläret. Q. Har biblioteken dagstidningar? Toggle menu visibility Ställ en ny fråga Sök Bläddra: Visa alla Språk English Svenska Ändra ämne 5 Avhandlingar och upps
https://libanswers.lub.lu.se/faq/3753 - 2026-05-23
Institutionen för kulturvetenskaper, Avdelningen för ABM, digitala kulturer och förlags- och bokmarknadskunskap Institutionen för kulturvetenskaper, Besöksadress LUX, hus C, Helgonagatan 3, Lund Webbadress www.kultur.lu.se LITTERATURLISTA Sida 1 av 2 2 Sida 3 av 2 Kurslitteratur för (ABMM52) Informationssökning och förmedling, 7,5 hp, VT 2026 Fastställd av institutionsstyrelsen eller motsvarande
https://www.ht.lu.se/media/utbildning/dokument/kurser/ABMM52/20261/ABMM52.litteraturlista.VT2026.docx - 2026-05-28
