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Our knowledge of the binding sites for neutralizing Abs (NAb) that recognize a broad range of HIV-1 strains (bNAb) has substantially increased in recent years. However, gaps remain in our understanding of how to focus B cell responses to vulnerable conserved sites within the HIV-1 envelope glycoprotein (Env). In this article, we report an immunization strategy composed of a trivalent HIV-1 (clade
BACKGROUND AND AIMS: Vanin-1 (gene name VNN1) is an enzyme with pantetheinase activity generating the amino-thiol cysteamine which is implicated in the regulation of red-ox status through its effect on glutathione. We tested the hypothesis that the rs2294757 VNN1 T26I polymorphism could affect blood pressure (BP) levels, hypertension prevalence, and risk of incident cardiovascular events. METHODS
In this report, a panel of European myeloma experts discuss the role of pomalidomide in the treatment of relapsed and refractory multiple myeloma (RRMM). Based on the available evidence, the combination of pomalidomide and low-dose dexamethasone is a well-tolerated and effective treatment option for patients with RRMM who have exhausted treatment with lenalidomide and bortezomib. The optimal start
Indicators of work role functioning (being at work, and being productive while at work) are important outcomes for persons with arthritis. As the worker productivity working group at OMERACT (Outcome Measures in Rheumatology), we sought to provide an evidence base for consensus on standardized instruments to measure worker productivity [both absenteeism and at-work productivity (presenteeism) as w
The ventral mesencephalon, containing the developing dopaminergic neurons of the substantia nigra-ventral tegmental region, was obtained from aborted human fetuses of 9-19 weeks of gestation. The tissue was grafted into the striatum of rats previously subjected to a 6-hydroxydopamine lesion of the mesostriatal dopamine pathway. The graft recipients were immunosuppressed by daily injections of Cycl
The incidence of Candida dubliniensis in immunocomprimised patients in Turkey has not yet been determined. In this study the presence of C. dubliniensis in oral rinse samples of human immunodeficiency virus (HIV)-positive patients and healthy controls were investigated. Phenotypic tests like inability of growth at 45 degrees C, colony formation on Staib agar, intracellular beta-D-glucosidase activ
CONTEXT: Fear of pain resonates with most people, in particular, in relation to dying. Despite this, there are still people dying with unrelieved pain.OBJECTIVES: We quantified the risk, and investigated risk factors, for dying with unrelieved pain in a nationwide observational cohort study.METHODS: Using data from Swedish Register of Palliative Care, we analyzed 161,762 expected deaths during 201
Objective: The aim of this study was to analyse differences in clinical presentation in patients with early (< 3 years’ duration) systemic sclerosis (SSc), comparing three age groups according to disease subsets. Method: Cross-sectional analysis of the prospective EULAR Scleroderma Trials and Research database (EUSTAR) was performed. Patients fulfilling preliminary American College of Rheumatology
The spatial energy distributions of beams of protons accelerated by ultrahigh intensity (>10^19 W/cm2) picosecond laser pulse interactions with thin foil targets are investigated. Using separate, low intensity (<10^13 W/cm2) nanosecond laser pulses, focused onto the front surface of the target foil prior to the arrival of the high intensity pulse, it is demonstrated that the proton beam profile ca
Sanfilippo syndrome type B (mucopolysaccharidosis III B) is a rare autosomal recessive disease caused by deficiency of alpha-N-acetylglucosaminidase, one of the enzymes required for the lysosomal degradation of heparan sulfate. The gene for this enzyme, NAGLU, recently was isolated, and several mutations were characterized. We have identified, in amplified exons from nine fibroblast cell lines der
Helicity-dependent total photoabsorption cross sections on the deuteron have been measured for the first time at ELSA (Bonn) in the photon energy range from 815 to 1825 MeV. Circularly polarized tagged photons impinging on a longitudinally polarized LiD target have been used together with a highly efficient 4 pi detector system. The data around 1 GeV are not compatible with predictions from existi
To assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of the Fc-inactivated anti-β amyloid (Aβ) monoclonal antibody (mAb) GSK933776 in patients with mild Alzheimer's disease (AD) or mild cognitive impairment (MCI).
I Bibeln materialiserad har åtta bibelutgåvor jämförts med varandra i syfte att försöka förstå hur den fysiska boken förändras, materiellt och funktionsmässigt, genom historien och på dagens digitaliserade bokmarknad. Den fysiska bokens förändring är av intresse då den samtida bokmarknaden präglas av ett förändrat medielandskap där den tryckta codexen bara är ett medium bland andra. Detta resulter
Media har tidigare konsumerats genom tv, bio, hyrfilm radio osv. Konsumenten har fått köpa film och musik i butik eller titta på tv och lyssna på radio. Med Internets framfart har denna traditionella mediakonsumption fått konkurens. I dag konsumeras media alltmer via internet genom playtjänster och liknande mediastreamingtjänster. Studiens syfte är att bidra med kunskap om kritiska framgångsfaktor
IVF och världsbanken är två grundpelare i det ekonomiska systemet. Ända sedan deras födelse vid Bretton Woods konferensen 1944 har de varit nyckelaktörer i uppbyggnaden av ekonomier. På senare år har organisationerna varit verksamma i att övervaka det monetära systemet och i kriget mot fattigdom världen runt. Men vad är det egentligen som skiljer de två organisationerna åt och vilka konsekvenser f
The purpose of this study was to explore whether stress influences emotion induction. An independent group design was conducted where participants of the experiment group were exposed to a stress induction while the control group wrote a non-stress inducing task. Following the manipulation, a sequence from the film Wall-E was shown with the intention to induce positive emotions. Shortly after the
Abstract - Svenska Denna kvalitativa uppsats syftar till att framföra subjektiva erfarenheter av att leva med Premenstruellt Dysforiskt Syndrom, PMDD på Engelska. Studiens fokus låg på att undersöka upplevelser av: (1) symptompåverkan på individerna med PMDS och deras arbetsplats; (2) påverkan på individens sociala liv och; (3) Vilket stöd föreslås och görs tillgängligt och hur stödet upplevs. NitThis qualitative essay's purpose was to relay subjective experiences of living with PMDD. The focus of the study was on experiences of: (1) impact of symptoms on the individuals with the PMDD and their workplace; (2) impact on the individual's social life and; (3) what aid is suggested and made available and how they are experienced. Nineteen people with PMDD were recruited from a Facebook
Personlig integritet i arbetslivet är tämligen oreglerad i svensk rätt och den reglering som finns är komplex och svåröverskådlig. Det är i synnerhet PuL som aktualiseras i fråga om arbetstagares personliga integritet, vilken i maj 2018 ersätts av GDPR. Den består likt PuL av allmänt hållna bestämmelser. Emellertid tillhandahåller GDPR stärkt skydd för individens personliga integritet och ökade skIntegrity in the workforce appears to be rather unregulated in the swedish law. The existing regulation is compound and difficult to get a grip of. In May, 2018, the Personal Data Act will be replaced by the GDPR, which in similar to the former consists of general provisions. However, the new legislation provides employees increased protection, but also more responsibilities for the employers. Th
The incidence of post-transfusion hepatitis non-A, non-B (PTH-NANB) was prospectively assessed among open-heart surgery patients from the southeast region of Sweden before the introduction of antihepatitis C virus (HCV) blood donor screening. Blood samples for alanine aminotransferase analysis were drawn before and 2, 3, and 4 months after transfusion. Surgery was performed in four centres. Of 190
