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Parkinson’s disease (PD) is a heterogenous disease with a varying age of onset, symptoms, and rate of progression. This heterogeneity requires the use of a variety of animal models to study different aspects of the disease. Neurotoxin-based approaches include exposure of rodents or non-human primates to 6-OHDA, MPTP, and agrochemicals such as the pesticide rotenone, the herbicide paraquat, and the
ST segment depression (STDE) has been found to be associated with cardiovascular disease in the elderly. Studies of the relation of ambulatory STDE to cognitive function in elderly persons aged 80 years or above is lacking. Objective: To study the association between STDE and cognition. Design and participants: A cross-sectional cohort study of 88 81-year-old men from the population study "Men bor
Objectives: Health promotion is on the global agenda. The risks targeted include smoking, hazardous alcohol consumption, nutrition and insufficient physical activity. Implementation of clinical health promotion, however, remains a major challenge. While several processes, models and frameworks for strategic implementation exist, very few have been tested in randomized designs. Testing a strategic
BACKGROUND: Men born in 1914 is a population-based cohort study of the epidemiology of cardiovascular and cerebral disease. Little is known about how diurnal variation in blood pressure (BP) levels influence cerebral perfusion in very elderly populations. OBJECTIVES: To study the association between systolic (SBP) and diastolic BP (DBP) levels, during the day and at night, expressed through 24 h a
Eight family caregivers of elderly dementia sufferers participated in in-depth interviews regarding their experiences of giving care. They were selected according to strain, isolation, disappointment and emotional involvement, measured on a 'caregiver burden' scale. Structural analyses of the interviews identified six categories reflecting the feelings and experiences of the caregivers. The first
The strain of caregiving associated with the care of demented persons living at home often continues after relocation, and group-living-care units (GL), designed for a small number of subjects, have been developed. The aim was to prospectively describe caregiver burden in relationship to symptoms of patients with dementia after relocation to GL. Sixty-four caregivers and 64 demented patients were
The sensitivity of interglacial Greenland temperature to orbital and CO 2 forcing is investigated using the NorthGRIP ice core data and coupled ocean-atmosphere IPSL-CM4 model simulations. These simulations were conducted in response to different interglacial orbital configurations, and to increased CO 2 concentrations. These different forcings cause very distinct simulated seasonal and latitudina
Tumor promoting phorbol esters stimulate Ca++ phospholipid-dependent protein kinase C. It has been suggested that this enzyme regulates the functional properties of different cell membrane receptors. In this study we investigated the effect of phorbol esters on α1-adrenoceptor binding and phosphatidylinositol metabolism in cultured smooth muscle cells derived from rabbit aorta. Treatment of these
Plant water storage is fundamental to the functioning of terrestrial ecosystems by participating in plant metabolism, nutrient and sugar transport, and maintenance of the integrity of the hydraulic system of the plant. However, a global view of the size and dynamics of the water pools stored in plant tissues is still lacking. Here, we report global patterns of seasonal variations in ecosystem-scal
This chapter examines the communicational dynamic between adaptive and flexible CSOs. It focuses on women’s issues and citizen protest movements on the one hand, and political parties on the other, against the background of the extended protests that took place in Romania in the first half of 2012. These protests led to two changes in the government coalition and a significant reshuffling of the R
DDT1 MF-2 cells, which are derived from hamster vas deferens smooth muscle, contain α1-adrenergic receptors (54,800 ± 2700 sites per cell) that are coupled to stimulation of inositol phospholipid metabolism. Incubation of these cells with tumor-promoting phorbol esters, which stimulate calcium- and phospholipid-dependent protein kinase, leads to a marked attenuation of the ability of α1-receptor a
Aims: We aimed to compare two treatment regimes, one with and one without postoperative precautions in hemiarthroplasty patients, in terms of dislocation rate and patient-reported outcome. Direct lateral approach was used. Patients and Methods: 394 patients were included in a cluster-randomized study 2010−2014. Depending on which ward they were admitted to, they were allotted to free rehabilitatio
We have synthesized and characterized a high-affinity alpha1-adrenergic receptor probe, 4-amino-6,7-dimethoxy-2[4'-[5''-(3-125I-iodo-4-aminophenyl)pentan oyl]-1'-piperazinyl]quinazoline (125I-A55453). This ligand binds reversibly to rat hepatic plasma membranes with high affinity (K(D) = 77 ± 6 pM), and it labels the same number of 'specific' prazosin-competable sites as the alpha1-adrenergic rece
We have synthesized and characterized a novel high affinity radioiodinated α1-adrenergic receptor photoaffinity probe, 4-amino-6,7-dimethoxy-2-[4-[5-(4-azido-3-[125I]iodophenyl)pentanoyl]-1-p iperazinyl] quinazoline. In the absence of light, this ligand binds with high affinity (K(D) = 130 pM) in a reversible and saturable manner to sites in rat hepatic plasma membranes. The binding is stereoselec
BACKGROUND: Amblyopia is the most common monocular visual impairment in Scandinavia. A visual screening programme for preschool children was introduced in Sweden in the 1970s to reduce the prevalence of amblyopia. The purpose of this study was to investigate the impact of this visual screening programme in adult men recruited to the armed forces in Sweden.METHODS: The prevalence of amblyopia was c
Aims: We observed a microvascular structure in the cerebral cortex that has not, to our knowledge, been previously described. We have termed the structure a ‘raspberry’, referring to its appearance under a bright-field microscope. We hypothesized that raspberries form through angiogenesis due to some form of brain ischaemia or hypoperfusion. The aims of this study were to quantify raspberry freque
In an earlier article, Inger Enkvist argues that the working conditions for the doctoral students in Sweden are too good since they are employed. We question her arguments and her conclusion. We show that there have not been a decline in the number of doctoral students since the universities started to employ doctoral students. Moreover, we argue that the new policy has improved the doctoral stude
