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Rigid or conformationally restricted compounds are intresting from a pharmacological point of view since they do not have to pay the entropy penalty paid by more flexible molecules in binding to e.g. a protein. In this thesis, synthetic transformations of a rigid tetracyclic oxanorbornene scaffold are described, yielding novel compounds with low molecular weight, rigid framework and high oxygen co

In the spectral region 2400-3160A of Eta Carinae, we have identifiedapproximately 500 absorption lines each with up to twenty velocitycomponents.The -512 km/s component is truely unique as 1) the typicalline width is <3 km/s, 2) the identified lines are in Fe I, Fe II, VII and Ti II, and 3) the lines originate from lower levels up to 2000cm-1 above the ground level. We have measured the velocity c

Popular Abstract in Swedish Jorden är ett ytterst komplext och dynamiskt system. Livet har format planeten och utvecklats i takt med förändrade livsvillkor. Ekosystemen kontrolleras i hög grad av klimatet. Snabbt förändrade villkor innebär betydande påfrestningar för åtskilliga arter och ekosystem, inklusive planetens mest dominerande art, människan. Avhandlingens huvudfokus är att undersöka samsThe Earth is a highly complex and dynamic system. Life has shaped the entire planet and evolved in response to living conditions. Ecosystems are heavily affected by climate. Rapidly changing conditions imply considerable stress on several species and ecosystems, as well as to the most dominant species on the planet. The main focus of this thesis is to investigate climate and anthropogenic interac

Ectomycorrhizae is a mutualistic association between roots of woody plants and a diverse range of soil fungi. The fungi exchange soil derived mineral nutrients for photosynthetic sugars from the host plant. The mycorrhizal symbioses are commonly found in all forest ecosystems and have a major ecological and economical importance. I have used comparative genomics, DNA microarrays and computational

We give a new proof of the Nirenberg-Treves conjecture: that local solvability of principal type pseudodifferential operators is equivalent to condition (Psi). This condition rules out sign changes from - to + of the imaginary part of the principal symbol along the oriented bicharacteristics of the real part. We obtain local solvability by proving a localizable a priori estimate for the adjoint op

Popular Abstract in Swedish Att få en övergripande förståelse för hur mänskliga celler påverkas av metallbaserade läkemedel är viktigt, eftersom de har visat sig vara väldigt effektiva för behandling av exempelvis testikel- och äggstockscancer. För att utforska bakomliggande orsaker har forskningsprojektets utgångspunkt varit att studera kliniskt välkarakteriserade metallbaserade läkemedel som exeGaining a detailed understanding of how human cells are affected by metal-based drugs is crucial, since these drugs have shown great potential in cancer treatment. Cisplatin is used to treat many different types of cancer, e.g. testicular, ovarian, melanoma, bladder, non-small cell lung cancer, small cell lung cancer, myelomas and lymphomas. The miRNA expression profiles in different human cancers

We report on a summary of fabricating and characterizing nanoscaled ferromagnetic single-electron transistors (F-SETs). One type of device is assembled with an atomic force microscope. A single 30 nm Au disc, forming the central island of the transistor, is manipulated with Angstrom precision into the gap between plasma oxidized Ni source and drain electrodes which are designed with different geom