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Gene set-based analysis methods have recently gained increasing popularity for analysis of microarray data. Several studies have indicated that the results from such methods are more reproducible and more easily interpretable than the results from single gene-based methods. A new method for ranking gene sets with respect to their association with a given predictor or response, using a new framewor
There are little data on the putative association between factors in the metabolic syndrome (MetS) and risk of bladder cancer. In the Metabolic Syndrome and Cancer project (Me-Can), measurements of height, weight, blood pressure and circulating levels of glucose, cholesterol, and triglycerides had been collected from 578,700 subjects in cohorts in Norway, Austria, and Sweden. We used Cox proportio
We show that light drives large-amplitude structural changes in thin films of the prototypical ferroelectric PbTiO3 via direct coupling to its intrinsic photovoltaic response. Using time-resolved x-ray scattering to visualize atomic displacements on femtosecond time scales, photoinduced changes in the unit-cell tetragonality are observed. These are driven by the motion of photogenerated free charg
Climate-induced migration, and particularly the issue of climate refugees, is subject to growing attention in global climate governance. The debate on the topic sees the convergence of conflicting discourses (ranging from those of conservative European governments to southern NGOs) onto apocalyptic narratives that forecast massive, abrupt and unavoidable flows of climate refugees. Such dystopian n
We report on the use of time resolved X-ray diffraction to measure the dynamics of strain in laser-excited graphite film of nanometer thickness, obtained by chemical vapour deposition (CVD). Heat transport in the CVD film is simulated with a 1-dimensional heat diffusion model. We find the experimental data to be consistent with a c-axis thermal conductivity of similar to 0.7 Wm(-1) K-1. This value
Arguments from explanation, i.e. arguments in which the explanatory value of a hypothesis or premise is appealed to, are common in science, and explanatory considerations are becoming more popular in metaphysics. The paper begins by arguing that explanatory arguments in science—even when these are metaphysical explanations—may fail to be explanatory in metaphysics; there is a distinction to be dra
Abstract in UndeterminedThis article presents an integrated environment for application scheduling, binding and routing used for the run-time reconfigurable, operator based, ROMA multimedia architecture. The environment is very flexible and after a minor modification can support other reconfigurable architectures. Currently, it supports the architecture model composed of a bank of single (double)
Athletes constantly report experiences of momentum during athletic contests, and they consider momentum as being an important factor for the outcome of a competition. However, researchers trying to capture momentum with quantitative methods see themselves confronted with inconclusive results. To explain this gap between athletes’ belief and results from quantitative data, it is hypothesised that m
BackgroundWarfarin is demonstrated to be superior in efficacy over antiplatelet agents for the prevention of stroke, but the relationship between warfarin and mortality is less clear. Our aim was to investigate this relationship in a large cohort of unselected patients with atrial fibrillation and ischaemic stroke. MethodsThis observational study was based on patients who were discharged alive and
High-palaeolatitude plesiosaur, mosasaur and, more rarely, dinosaur fossils are well known from the Maungataniwha Sandstone Member of the Tahora Formation in Mangahouanga Stream, Hawkes Bay, New Zealand. A palynological investigation of strata exposed along Mangahouanga Stream and of transported boulders hosting vertebrate fossils reveals well-preserved assemblages dominated by terrestrial pollen
Original connections among the world's extant Archean cratons are becoming tractable by the use of integrated paleomagnetic and geochronologic studies on Paleoproterozoic mafic dyke swarms. Here we report new high-quality paleomagnetic data from the similar to 2.41 Ga Widgiemooltha dyke swarm of the Yilgarn craton in western Australia, confirming earlier results from that unit, in which the primar
The electronic structure of superheavy elements (Z ≥ 104) and their chemical properties are dominated by relativistic effects. Recently two superheavy elements were recognized by the IUPAC and named flerovium (Fl, Z = 114) and livermorium (Lv, Z = 116). Fl is the heaviest element with which chemical experiments were performed. Here, we report on experiments that help answering the long-standing qu
We propose and analyze a high-fidelity readout scheme for a single-instance approach to quantum computing in rare-earth-ion-doped crystals. The scheme is based on using different elements as qubit and readout ions, where the readout ions are doped into the material at a much lower concentration than the qubit ions. It is shown that by allowing the qubit ion sitting closest to a readout ion to act
BACKGROUND: Interactive behavior change technology (eg, computer programs, Internet websites, and mobile phones) may facilitate the implementation of lifestyle behavior interventions in routine primary health care. Effective, fully automated solutions not involving primary health care staff may offer low-cost support for behavior change. OBJECTIVES: We explored the effectiveness of an electronic
Novel agents in combination with melphalan and prednisone (MP) significantly improved progression-free survival (PFS) and overall survival (OS) in multiple myeloma (MM). Randomized trials comparing MP plus bortezomib (VMP) versus MP plus thalidomide (MPT) are lacking. Nine hundred and fifty-six elderly (>65 years) newly diagnosed MM patients from six European randomized trials were retrospectively
Background: Symptom control by drug treatment is the most important task in routine clinical care of patients with schizophrenia. Structured assessment methods are needed in this task but not used much. The US-developed Positive and Negative Syndrome Scale (PANSS) is a standard tool for symptom assessment. The Psychosis Evaluation tool for Common use by Caregivers (PECC) was constructed in Europe
Objective To determine whether BCG revaccination at 19 months of age reduces overall child mortality. Design Randomised trial, with follow-up to age 5. Setting A health project in Bissau, Guinea-Bissau, which maintains a health and demographic surveillance system in an urban area with 90 000 inhabitants. Participants 2871 children aged 19 months to 5 years with low or no reactivity to tuberculin a
