Drug-induced response and antibody-dependent cellular cytotoxicity in microfluidic cultures with dynamic flow
Current in-vitro models for mantle cell lymphoma (MCL) are standardized 2D cell cultures. These models do not incorporate the complexities seen in the human body 3D environment such as dynamic fluid flow or mechanical stress which are known to affect cellular behavior. MCL is a subtype of Non-Hodgkin’s lymphoma (NHL) with a poor prognosis often involving relapses and the overall survival is low. F