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Mapping a New History of the Ecological Turn : The Circulation of Environmental Knowledge in Sweden 1967
This essay introduces environmental historians to a new approach inspired by the burgeoning field of Wissensgeschichte; that is, the study of societal circulation of knowledge. It is argued that this new method can help us to better map out and analyse the emergence of modern environmentalism in society at large. To demonstrate the practical implications of the argument the essay is centred on an
Emotional, physical, and sexual abuse and the association with symptoms of depression and posttraumatic stress in a multi-ethnic pregnant population in southern Sweden
Objectives: This study aims to describe the prevalence of emotional, physical, and sexual abuse and analyze associations with symptoms of depression and posttraumatic stress (PTS) in pregnancy, by ethnic background. Study design: This is a cross-sectional study of the Swedish data from the Bidens cohort study. Ethnicity was categorized as native and non-native Swedish-speakers. Women completed a q
Increased deep pain sensitivity in persistent musculoskeletal pain but not in other musculoskeletal pain states
BackgroundPressure pain thresholds (PPTs) in a non-painful body area are known to be affected in some chronic pain states. The aim of this study is to investigate PPTs in a pain-free body part in relation to pain persistence and intensity in patients with musculoskeletal pain. MethodsPatients with musculoskeletal pain were divided into three different pain groups: acute pain (pain duration 3 mont
Association between shift work history and performance on the trail making test in middle-aged and elderly humans : The EpiHealth study
Shift work has been proposed to promote cognitive disturbances in humans; however, conflicting evidence is also present. By using data from 7143 middle-aged and elderly humans (45-75 years) who participated in the Swedish EpiHealth cohort study, the present analysis sought to investigate whether self-reported shift work history would be associated with performance on the trail making test (TMT). T
The absence of aldehyde dehydrogenase 1 A1-positive cells in benign mammary stroma is associated with risk factors for breast cancer
In this study, aldehyde dehydrogenase 1 (ALDH1)-expressing cells in stroma of histologically normal breast tissue from premenopausal women were investigated in situ regarding cellular morphology, cell distribution, and relation to the additional stem cell markers, CD44 (+) and CD24 (-). These results were correlated with hormonal and genetic risk factors for breast cancer. Triple immunofluorescenc
Long-term risk of renal and urinary tract diseases in childhood cancer survivors : A population-based cohort study
Background Childhood cancer has been associated with long-term risk of urinary tract diseases, but risk patterns remain to be comprehensively investigated. We analysed the lifetime risk of urinary tract diseases in survivors of childhood cancer in the Nordic countries. Methods We identified 32,519 one-year survivors of childhood cancer diagnosed since the 1940s and 1950s in the five Nordic cancer
The value of specialist orthopaedic nurses
Does the intensity and quality of treatment and not only the factor VIII level influence global hemostasis in patients with hemophilia A?
Body mass index and suicide methods
Overweight and obesity is associated with lower rates of suicide. However, little is known about the association with different suicide methods. We studied the association between groups of body mass index and suicide methods. We identified all medicolegal autopsy cases with a cause of death due to external causes in Sweden during 1999-2013 (N = 39,368) and included 11,715 suicides and 13,316 acci
A reduced population of CD103+CD11b+ dendritic cells has a limited impact on oral Salmonella infection
CD103+CD11b+ dendritic cells (DC) are the major migratory DC subset in the small intestine lamina propria (siLP) and their survival is dependent on the transcription factor interferon regulatory factor 4 (IRF4). Mice with a DC-specific deletion of irf4 (CD11c-cre.Irf4 mice) have reduced mucosal CD103+CD11b+ DC and altered T cell differentiation to protein antigen. The influence of CD103+CD11b+ DC
Pulmonary and pleural lymphatic endothelial cells from pediatric, but not adult, patients with Gorham-Stout disease and generalized lymphatic anomaly, show a high proliferation rate
Background: Gorham-Stout disease (OMIM 123880) and generalized lymphatic anomaly are two rare disorders of lymphendothelial growth in which thoracic involvement with chylothorax is a feared complication. Currently it is believed that both disorders are prenatal malformations that progress slowly after birth. Several pharmaceuticals with antiproliferative properties, including interferon-α-2b, rapa
Structural conditions for oscillations and multistationarity in aggregate monotone systems
We provide necessary and sufficient structural conditions for multistationarity and oscillations in aggregate monotone systems, defined as the interconnection of stable monotone components. Our classification is based on the presence of exclusively positive or exclusively negative cycles in the system aggregate graph, whose nodes are the monotone subsystems. The results presented here scale up the
Plant tuning: a robust Lyapunov approach
We consider the problem of tuning the output of a static plant whose model is unknown, under the only information that the input-output function is monotonic in each component or, more in general, that its Jacobian belongs to a known polytope of matrices. As a main result, we show that, if the polytope is robustly non-singular (or has full rank, in the non-square case), then a suitable tuning sche
Molecular Titration Promotes Oscillations and Bistability in Minimal Network Models with Monomeric Regulators
Molecular titration is emerging as an important biochemical interaction mechanism within synthetic devices built with nucleic acids and the CRISPR/Cas system. We show that molecular titration in the context of feedback circuits is a suitable mechanism to enhance the emergence of oscillations and bistable behaviors. We consider biomolecular modules that can be inhibited or activated by input monome
A switched system approach to dynamic race modelling
The paper presents and analyses some nonlinear continuous-time dynamic models of social systems whose members, groups or individuals, may change partners and/or opponents at any time, according to a greedy criterion. The main structural properties of these models, which belong to the class of positive switching systems, are investigated with particular regard to the existence of solutions, their p
Polyhedral Lyapunov functions for structural stability of biochemical systems in concentration and reaction coordinates
Structural properties, independent of specific parameter values, can explain the robustness of biochemical systems. In this paper we consider the framework previously proposed by the authors to assess structural stability of biochemical reaction networks with monotone reaction rates, which considers systems in concentration coordinates, and we show that the results can be applied to systems in rea
Neural stem cell transplantation for the treatment of primary torsion dystonia : A case report
Primary torsion dystonia (PTD) occurs due to a genetic mutation and often advances gradually. Currently, there is no therapy available that is able to inhibit progression. Neural stem cells (NSCs) are being investigated as potential therapies for neurodegenerative diseases, such as stroke and trauma. The present study evaluated the clinical effectiveness of NSC transplantation in an 18-year-old ma
Computing the structural influence matrix for biological systems
We consider the problem of identifying structural influences of external inputs on steady-state outputs in a biological network model. We speak of a structural influence if, upon a perturbation due to a constant input, the ensuing variation of the steady-state output value has the same sign as the input (positive influence), the opposite sign (negative influence), or is zero (perfect adaptation),