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Assessing transitions through socio-technical configuration analysis – a methodological framework and a case study in the water sector

Classic accounts of transitions research have predominantly built on reconstructions of historical transition processes and in-depth case studies to identify and conceptualize socio-technical change. While such approaches have substantively improved our understanding of transitions, they often suffer from methodological nationalism and a lack of generalizability beyond spatial and sectoral boundar

Association between cardiovascular disease- and inflammation-related serum biomarkers and poor lung function in elderly

Background: Cardiovascular disease (CVD) is a common comorbidity in chronic obstructive pulmonary disease (COPD) and reduced lung function is an important risk factor for CVD and CVD-related death. However, the mechanisms behind the increased risk for CVD in COPD patients are not fully understood. Methods: We examined the association between CVD- and inflammation-related serum biomarkers, and pulm

Towards a unified theory of market prices: turning to pricing in practice

This article proceeds from the question: how do prices in markets work? In socioeconomic theories, I find two answers to this question. The structural-coordinative approach explains prices as outcomes—coordinative effects of pricing scripts installed by exogenous, institutionalized social structures. The performative-epistemological approach explains prices as market devices—endogenous performativ

The effect of postoperative anticoagulation on false lumen patency after surgery for acute type A aortic dissection

Background: Patent false lumen has been shown to have a negative impact on prognosis after surgery for acute type A aortic dissection (ATAAD). We aimed to assess the effect of postoperative anticoagulation on false lumen patency and clinical outcomes in relation to false lumen status. Methods: Postoperative computed tomographies of 156 patients undergoing ATAAD DeBakey type I surgery were retrospe

Health care utilization among patients with oesophageal and gastric cancer : the impact of initial treatment strategy and assignment of a contact nurse

Background: Patients diagnosed with oesophageal and gastric cancer face a poor prognosis and numerous challenges of symptom management, lifestyle adjustments and complex treatment regimens. The multifaceted care needs and rapid disease progression reinforce the need for proactive and coherent health care. According to the national cancer strategy, providing coherent health care and palliative supp

Artificial intelligence enabled radio propagation for communications – Part II: Scenario identification and channel modeling

This two-part paper investigates the application of artificial intelligence (AI) and in particular machine learning (ML) to the study of wireless propagation channels. In Part I, we introduced AI and ML as well as provided a comprehensive survey on ML enabled channel characterization and antenna-channel optimization, and in this part (Part II) we review state-of-the-art literature on scenario iden

Socioeconomic correlates of incident and fatal opioid overdose among Swedish people with opioid use disorder

Background: Opioid overdose (OD) and opioid OD death are major health threats to people with opioid use disorder (OUD). Socioeconomic factors are underexplored potential determinants of opioid OD. In this study, we assessed socioeconomic and other factors and their associations with incident and fatal opioid OD, in a cohort consisting of 22,079 individuals with OUD. Methods: We performed a retrosp

Aspirin as secondary prevention in colorectal cancer liver metastasis (ASAC trial) : study protocol for a multicentre randomized placebo-controlled trial

Background: Colorectal cancer is one the most common cancers in the western world with increasing incidence. Approximately 50% of the patients develop liver metastases. Resection of liver metastases is the treatment of choice although almost half of the resected patients get recurrence in the liver. Methods: The ASAC trial is a Scandinavian, multicentre, double-blinded, randomized, placebo-control

High CYP27A1 expression is a biomarker of favorable prognosis in premenopausal patients with estrogen receptor positive primary breast cancer

27-hydroxycholesterol (27HC), synthesized from cholesterol by the enzyme CYP27A1, differentially impacts estrogen receptor positive (ER+) breast cancer (BC) cell growth depending on estrogen levels. This study examined the association between CYP27A1 expression and prognosis in a cohort of 193 premenopausal patients with lymph node-negative primary BC with limited exposure to adjuvant systemic can

Quantitative Measures for Recognition of Negotiation Style and Activity

Group Decision and Negotiation Support Systems need to provide support for different types of communication activities. The purpose of this study is to identify and test cross-linguistic measures for recognition of communication activities in order to provide support for various forms of group decision and negotiation support systems, including e-negotiation support systems. The study uses quantit

Comparative risk of suicide by specific substance use disorders : A national cohort study

Substance use disorders (SUDs) are important risk factors for suicide, yet little is known about how suicide risks vary by specific SUDs. We examined these risks for the first time in a large general population to facilitate comparisons across SUDs. A national cohort study was conducted of all 6,947,191 adults in Sweden. SUDs (opioid, sedative/hypnotic, hallucinogen, cannabis, amphetamine, cocaine

The importance of environmental microbes for Drosophila melanogaster during seasonal macronutrient variability

Experiments manipulating the nutritional environment and the associated microbiome of animals have demonstrated their importance for key fitness components. However, there is little information on how macronutrient composition and bacterial communities in natural food sources vary across seasons in nature and on how these factors affect the fitness components of insects. In this study, diet sample

A new well-preserved ostracod fauna from the middle Burdigalian (lower Miocene) of the North Alpine Foreland Basin

The marine middle Burdigalian sediments of the North Alpine Foreland Basin (NAFB) or Molasse Basin are well known for abundant occurrences of benthic foraminifers and ostracods. However, taxonomic studies of ostracod assemblages are comparatively rare and, given its abundance, the group remains heavily understudied. Here we report a new, rich and well-preserved ostracod fauna from the middle Burdi

Reduced expression of OXPHOS and DNA damage genes is linked to protection from microvascular complications in long-term type 1 diabetes : the PROLONG study

Type 1 diabetes is a chronic autoimmune disease requiring insulin treatment for survival. Prolonged duration of type 1 diabetes is associated with increased risk of microvascular complications. Although chronic hyperglycemia and diabetes duration have been considered as the major risk factors for vascular complications, this is not universally seen among all patients. Persons with long-term type 1

Efficacy and safety of pelvic organ prolapse surgery with porcine small intestinal submucosa graft implantation

Objective: The ideal implant material for the surgical repair of pelvic organ prolapse in women is yet to be found. This retrospective study aims to evaluate a porcine small intestinal submucosa (SIS) graft (Surgisis™). Study design: We reviewed the medical records of women that were operated upon for pelvic organ prolapse using implantation of SIS graft and we examined the short-term complication

The PROCEM study protocol : Added value of preoperative contrast-enhanced mammography in staging of malignant breast lesions - a prospective randomized multicenter study

Background: Correct preoperative estimation of the malignant extent is crucial for optimal planning of breast cancer surgery. The sensitivity of mammography is lower in dense breasts, and additional imaging techniques are sometimes warranted. Contrast-enhanced mammography (CEM) has shown similar sensitivity and in some cases better specificity, than magnetic resonance imaging (MRI) in small, obser