A major hallmark of Parkinson's disease (PD) is the presence of Lewy bodies (LBs) in certain neuronal tissues. LBs are protein-rich inclusions, in which α-synuclein (α-syn) is the most abundant protein. Since these inclusions are not present in healthy individuals, despite the high concentration of α-syn in neurons, it is important to investigate whether natural control mechanisms are present to e

Endohedral metallofullerenes, formed by encaging Gd inside fullerenes like C80, can exhibit enhanced proton relaxitivities compared with other Gd-chelates, making them the promising contrast agents for magnetic resonance imaging (MRI). However, the underlying key energy scales of Gd x Sc3-x N@C80 (x = 1-3) remain unclear. Here, we carry out resonant inelastic X-ray scattering (RIXS) experiments on

High chromium white cast irons (HCCI) with high hardness and abrasiveness owing to a particular combination of hard primary and eutectic carbides were used as workpiece materials for longitudinal turning with binderless cBN (bcBN) and high cBN (hcBN) tools. The materials with low and high Si content were used in as-cast and quenched states. Binderless cBN is prone to cratering and flank wear, whil

The AGATA (Advanced GAmma Tracking Array) tracking detector is being designed to far surpass the performance of the previous generation, Compton-suppressed arrays. In this paper, a characterization of AGATA is provided based on data from the second GSI campaign. Emphasis is placed on the proper corrections required to extract the absolute photopeak efficiency and peak-to-total ratio. The performan

The unified knowledge on power converter design and manufacturing technology establishes a powerful tool, where the cost and topology realization can be analyzed simultaneously. This paper collects the design practice and cost estimation of various components in a power electronics converter and unites that to a choice of the assembling and manufacturing processes and resulting cost of the complet

Dementia is a global problem and major target for health care providers. Although up to 45% of cases are primarily or partly due to cerebrovascular disease, little is known of these mechanisms or treatments because most dementia research still focuses on pure Alzheimer's disease. An improved understanding of the vascular contributions to neurodegeneration and dementia, particularly by small vessel

Ischemic stroke, caused by middle cerebral artery occlusion, leads to long-lasting formation of new striatal neurons from neural stem/progenitor cells (NSPCs) in the subventricular zone (SVZ) of adult rodents. Concomitantly with this neurogenic response, SVZ exhibits activation of resident microglia and infiltrating monocytes. Here we show that depletion of circulating monocytes, using the anti-CC

A method for synthesizing representative weather data for future climate out of regional climate models (RCMs) was introduced previously for the energy simulation of buildings (Nik, 2016). The method suggests creating one typical and two extreme data sets based on the distribution of the outdoor dry bulb temperature (Tdrybulb). This article extends the application of such weather data in the hygro

Growth orientation is important for understanding why some young firms grow but not others, but research remains silent on the intermediary mechanisms mediating the growth orientation–firm growth relationship. We study 282 Swedish firms and show that various innovative activities mediate the growth orientation–firm growth relationship. These mediating innovative activities include informal activit

This doctoral thesis uses a meta-critical method with an epistemological approach. The corpus consists of the doctoral theses presented in the United States about the novels of the Peruvian-Spanish writer and Nobel Prize winner in 2010 Mario Vargas Llosa, one of the most outstanding Spanish-speaking authors, with an extensive literary production. The study covers the 56 doctoral theses presented b

This article aims to analyze the pursuit of happiness in the characters of three novels published every twenty years or so since 1963. The purpose is to show the real motivations of each character in the pursuit of happiness in each novel. Another objective is to show that Vargas Llosa's characters strive to find happiness despite the more diverse and adverse circumstances in which the author has

Este trabajo se ciñe exclusivamente al testamento literario que los Nobel de Literatura nos han regalado a modo de discurso. El objetivo ha sido desgranar dichos discursos para ver similitudes o diferencias y extraer las pertinentes reflexiones gracias a un material lleno de talento y altamente cualificado por quienes han dedicado sus vidas al servicio de la literatura. El método ha sido analizar

AIM: The relative roles(s) of impaired insulin secretion vs. insulin resistance in the development of gestational diabetes mellitus depend upon multiple risk factors and diagnostic criteria. Here, we explored their relative contribution to gestational diabetes as defined by the WHO 1999 (GDM1999) and adapted WHO 2013 (GDM2013) criteria, excluding the 1-h glucose value, in a high-risk Indian popula