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We review the role of two susceptibility genes; G72 and DAAO in glutamate neurotransmission and the aetiology of schizophrenia. The gene product of G72 is an activator of DAAO (D-amino acid oxidase), which is the only enzyme oxidising D-serine. D-serine is an important co-agonist for the NMDA glutamate receptor and plays a role in neuronal migration and cell death. Studies of D-serine revealed low
Background: The main purpose for measuring urinary free sialic acid (FSA) is to diagnose sialic acid (SA) storage diseases. Elevated amounts of conjugated sialic acid (CSA) are observed in several diseases indicating the need to quantify CSA as well. A LC-MS/MS method for quantification of FSA and total sialic acid (TSA) in urine is developed and validated. Methods: FSA is analyzed directly after
Only for three of the known defects in the metabolism of the amino acidsGABA, glycine, serine, and proline has a more-or-less efficient treatment been reported: the GABA catabolic defect, succinic semialdehyde dehydrogenase deficiency (vigabatrin, causing substrate depletion by inhibition of GABA transaminase); the glycine catabolic defect, nonketotic hyperglycinemia (diet combined with benzoate a
The building industry demands ever more effective structural elements with a multitude of requirements at the same time. There is increasing interest for load-bearing glass elements which can be deployed in timber structures, e.g. in the outer façade or as column or beam elements within the building. In an on-going research project, the materials glass, timber and the adhesive combining the for
The EU lacks competence to regulate research in a comprehensive manner, yet furthering research is one of its aspirations. Data protection, however, is an area within which the EU has legislated extensively. During the development of the General Data Protection Regulation (GDPR), an important issue to tackle was how to balance the EU aspirations, on the one hand, with limited competences in resear
Salt-containing supramolecular assemblies of rigid-rod polymers tethered with flexible ion-solvating side chains represent a synthetic pathway towards thin ion-conducting solid electrolyte membranes with high dimensional stability. In the present work we have synthesized poly(p-phenylene)s (PpPs) carrying di-, tri- and tetra(ethylene oxide) side chains, respectively. p-Dichlorophenyl oligo(ethylen
There is sparse direct experimental evidence that atomic nuclei can exhibit stable "pear" shapes arising from strong octupole correlations. In order to investigate the nature of octupole collectivity in radium isotopes, electric octupole (E3) matrix elements have been determined for transitions in ^{222,228}Ra nuclei using the method of sub-barrier, multistep Coulomb excitation. Beams of the radio
Applying for ethical review is common among many social scientists today, even for projects very far from the bio-medical origins and design of the review process. This article critically discusses the clash between ethical review and ethnography in a Swedish context. It is argued that today’s committee-driven and form-based review fits poorly with research built on flexible, pragmatic and emergen
All growth‐critical perspectives have the common starting point that the ecological crisis and the increase in social inequality are basic features of high‐consumption capitalism and its spread from North America and Europe to the rest of the world. The common goal is thus to re‐embed productionand consumption patterns into planetary limits through a decrease in material and energy throughputs, pa
