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Colonized bank voles (Clethrionomys glareolus) originating from Sweden developed type 1 diabetes. Animals became polydipsic, glucosuric, and hyperglycemic and gradually developed a lethal ketoacidosis. Pancreas in animals with end-stage disease showed total destruction of islet cells. Interestingly, also a high proportion of wild bank voles in cyclic populations that were trapped at (or close to)

Media coverage is often held responsible for the erosion of public support for European integration. At the same time, a well-functioning political journalism is also held up as an important requirement for EU democracy. Set against this background of confl icting perceptions of the media, this report analyzes political journalism’s critical performance in the realm of EU constitutionmaking. The r

Thiazolidinediones are antidiabetic agents that decrease insulin resistance. Emerging evidence indicates that they present beneficial effects for the vasculature beyond glycemic control. The aim of this open-label observational study was to determine the effect of the thiazolidinedione rosiglitazone on novel cardiovascular risk factors, namely, lipoprotein(a) [Lp(a)], C-reactive protein (CRP), hom

I artikeln presenteras Viktor Rydbergs journalistik i tidningen Tomtebissen från 1857. Därefter följer i helhet den första artikeln som Rydberg lät publicera i tidningen.

Recently, we and others reported a recurrent t(7;12)(q36;p13) found in myeloid malignancies in children < or =18 months of age and associated with a poor prognosis. Fluorescence in situ hybridization studies mapped the 12p13 breakpoint to the first intron of ETV6 and narrowed down the region of 7q36 involved. By using the sequences made public recently by the Human Genome Project, two candidate ge

The aim of this study was to characterize polypeptide components of the capture net spun by trichopteran larvae Hydropsyche slossonae (Banks) (Trichoptera: Hydropsychidae). Thirty-one polypeptide bands were identified by SDS - polyacrylamide gel electrophoresis (SDS-PAGE) from extracted net material, with molecular weights ranging from 8500 to 179 000. Comparison with published data on Bombyx mori

Rapporten innehåller sex från varandra fristående avsnitt som behandlar olika flödesproblem och styr- och reglertekniska frågor inom solvämetekniken. Ämnen som berörs är bl a flödesproblem i seriekopplade kollektorer, reglering av solkollektortemperatur och styrsystemets betydelse för insamlad solenergi.

Popular Abstract in Swedish Denna avhandling behandlar tre centrala områden i finansiell ekonomi i allmänhet och portföljvalsteori i synnerhet: riskmåttet, estimeringsrisk och tidsdiversifiering. Avhandlingen består av fem kapitel varav ett är ett kort introduktionskapitel. De första två kapitlen behandlar ett alternativt mått på risk, lower partial moment (LPM). Detta alternativa mått behandlar eThis thesis is devoted to the analysis of three important issues in financial economics in general and portfolio selection in particular: the risk measure, estimation risk and time diversification. Besides a short introductory chapter the thesis consists of four empirical essays. In the second chapter, the effect of estimation risk on the efficient frontier in the lower partial moment framework is

Models of Parkinson's disease (PD) based on selective neuronal death have been used to study pathogenic mechanisms underlying nigral cell death and in some instances to develop symptomatic therapies. For validation of putative neuroprotectants, a model is desirable in which the events leading to neurodegeneration replicate those occurring in the disease. We developed a human in vitro model of PD b

This paper discusses the reasons for the recent success of Swedish popular music abroad. It departs from recent Swedish economic reports showing that the increase in exports of Swedish music per capita is comparable to, and even exceeds, those of the United Kingdom and the United States, and presents theories about why Swedish popular music exports have grown during the last years. A method of mu

The use of short interfering RNAs (siRNA) for selective suppression of protein production has rapidly become a commonly used technique for transient modulation of protein levels. In the present paper, we investigate whether introduction of platinated bases in the sense strand can be used to modulate the efficacy of siRNAs. Four different siRNAs were studied, all targeting the initial AU-rich 3' UT

We studied the association between alexithymia (20-item Toronto Alexithymia Scale, TAS-20) and obesity, and also assessed the construct validity of the TAS-20 in terms of personality dimensions in obese patients. The TAS-20 and its subscales were analysed for their correlations with the NEO Personality Inventory - Revised (NEO PI-R) in an obese sample of 259 patients. Obesity was associated with h

The mechanistic implications of the kinetic behaviour of a fusion protein of mitochondrial malate dehydrogenase and citrate synthase have been reanalysed in view of predictions based on experimentally determined kinetic parameter values for the dehydrogenase and synthase activities of the protein. The results show that the time-course of citrate formation from malate in the coupled reaction cataly

In flowering plants, the onset and duration of female receptivity vary among species. In several species the receptive structures wilt upon pollination. Here we explore the hypothesis that postpollination wilting may be influenced by pollen and serve as a general means to secure paternity of the pollen donor at the expense of female fitness. Taking a game-theoretical approach, we examine the poten

In a road simulator study, a significant source of sub-micrometer fine particles produced by the road-tire interface was observed. Since the particle size distribution and source strength is dependent on the type of tire used, it is likely that these particles largely originate from the tires, and not the road pavement. The particles consisted most likely of mineral oils from the softening filler