MMP-13 substrate specificity in cartilage breakdown
MMP13 (Collagenase 3) is a member of the matrix metalloproteinase (MMP) family. In pathology it is overexpressed in rheumatoid arthritis (RA), osteoarthritis (OA) and human carcinomas. It is secreted in its inactive proforms from which it can be activated. The project studies how MMP13 can degrade/digest the normal femoral head human articular cartilage. Peptides were separated using reversed phas
