TP53 is the most frequently mutated gene in human cancer. This gene shows not only loss-of-function mutations but also recurrent missense mutations with gain-of-function activity. We have studied the primary bone malignancy osteosarcoma, which harbours one of the most rearranged genomes of all cancers. This is odd since it primarily affects children and adolescents who have not lived the long life

Aim: The study aimed to explore the experiences of care and recovery among older patients treated for physical trauma. Design: A qualitative study with a constructivist grounded theory design. Methods: Fifteen in-depth interviews with older adults recovering from physical trauma were conducted and analysed between 2019 and 2023, in accordance with grounded theory methodology. Results: The findings

Purpose: The use of molecular radiotherapy (MRT) has been rapidly evolving over the last years. The aim of this study was to assess the current implementation of dosimetry for MRTs in Europe. Methods: A web-based questionnaire was open for treating centres between April and June 2022, and focused on 2020–2022. Questions addressed the application of 16 different MRTs, the availability and involveme

Shocked zircon from impactites from the Mien impact structure, Sweden, has been investigated with the aim to date the impact event and correlate the degree of U–Pb age resetting with shock-related microtextures. In situ U–Pb spot isotope analyses of granular and microporous–granular zircon grains from the impact melt rocks give an age of 120.0 ± 1.0 Ma. This essentially confirms the previous best

What is the purpose of lengthy negotiations when a coalition government forms? Do they make a difference in coalition policy-making? Negotiations that produce policy agreements between coalition partners have been suggested to strengthen the capacity of coalition governments to make policy reforms. We argue that bargaining time, regardless if it results in a written policy agreement or not, is an

In most non-fullerene organic solar cells comprising bulk-heterojunction active layers, the inter-domain connectivity of small-molecule acceptors is generally inferior to those of polymeric donors due to their intrinsic short-range ordering. This issue is even exacerbated by the physiochemical mismatch between acceptor-phases and metal-oxide electron transport layers in most inverted n-i-p devices

This paper aims to foreground the importance of emotions in water diplomacy in general and in Nile water diplomacy in particular. Water diplomacy does not operate from a clean slate, but in a socio-hydropolitically mediated context which is, in turn, imbued with emotions. The existing water diplomacy approach primarily operates with the assumption that the riparian state is a rational actor. Howev

Efter det att Sverige ratificerade Europakonventionen om kommunal självstyrelse (the European Charter of Local Self-Government) 1989, den s.k. självstyrelsekonventionen, har ett antal reformer av det lokala och regionala självstyret ägt rum. Frågan är i vilken utsträckning dessa reformer kan ses som anpassningar till konventionen. Analyser av granskningsrapporter och förarbeten indikerar att refor

The solid-liquid interface, where corrosion reactions occur, is notoriously difficult to study in operando conditions. Few experimental techniques can provide surface sensitivity and spatial and temporal resolution and are compatible with liquid environments. 2-Dimensional surface optical reflectance (2D-SOR) is an emerging optical technique providing microscopic information with high temporal res

Introduction: Methylation analysis of the promoter region of tumor-suppressor genes has previously shown high sensitivity for detection of high-grade cervical intraepithelial neoplasia (CIN) and cancer. HPV-testing has a high sensitivity to identify women at risk to develop cancer, and has been implemented in cervical screening programs in several countries. But in most HPV-positive women the infe

The conveniences of remote work are various, but a surge in cyberthreats has heavily affected the optimal processes of organizations. As a result, employees' cybersecurity awareness was jeopardized, prompting organizations to require improvement of cybersecurity processes at all levels. This paper explores which cybersecurity aspects are more relevant and/or relatable for remote working employees.

Based on an analysis of qualitative research papers published between 2019 and 2021 in four top-tier management journals, we outline three interrelated silences that play a role in the objectification of qualitative research: silencing of noninterview data, silencing the researcher, and silencing context. Our analysis unpacks six silencing moves: creating a hierarchy of data, marginalizing noninte

Innovation in artificial intelligence (AI) is transforming cities in unprecedented ways. In this chapter, we unpack the connections between AI and the urban by introducing the concept of urban AI and reflecting on its most prominent incarnations: autonomous vehicles, urban robots, city brains and urban software agents. We then illustrate how the emergence of urban AI is producing a new urbanism th

Paediatric prospective studies of coeliac disease with longitudinal collection of biological samples and clinical data offer a unique perspective on disease risk. This Review highlights the information now available from international paediatric prospective studies on genetic and environmental risk factors for coeliac disease. In addition, recent omics studies have made it possible to study comple

Introduction: Single Bicycle Brashes (SBCs) are common, and underreported in official statistics. In urban environments, light rail tram tracks are a frequent factor, however, they have not yet been the subject of engineering analysis. Method: This study employs video-based analysis at nine Dublin city centre locations and introduces a predictive model for crossing success on tram tracks, utilisin

Purpose: An increasing number of children and young adults with complex medical conditions and respiratory failure are treated with home mechanical ventilation (HMV). The current study aimed to describe how young adults using HMV experience their everyday life with the ventilator, their physical impairments and their opportunities for an educational and professional career. Materials and methods:

How can ludic play frame and assist the participants' interactions in an immersive opera? The Consultant's Quest was developed as an artistic response to the idea and the challenge of integrating articulated game-playing as a both methodic and affective instrument in relation to operatic elements. Presented as a card-driven board game in connection to the operatic experience The Prophecies, The CoHow can ludic play frame and assist the participants' interactions in an immersive opera? The Consultant's Quest was developed as an artistic response to the idea and the challenge of integrating articulated game-playing as a both methodic and affective instrument in relation to operatic elements. Presented as a card-driven board game in connection to the operatic experience The Prophecies, The Co

In this paper, a high-isolation two-port co-linearly polarized (co-LP) composite antenna is proposed. Dipole and W8JK array modes with co-LP omnidirectional patterns can be simultaneously supported by a plate with two etched back-to-back tapered slots. A microstrip differential and a T-divider coupling feeding networks are developed to selectively excite the dipole and W8JK modes, which results in