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Genome-wide CRISPR/Cas9 screen identifies regulators of BCMA expression on multiple myeloma cells
Overcoming small-bandgap charge recombination in visible and NIR-light-driven hydrogen evolution by engineering the polymer photocatalyst structure
Designing an organic polymer photocatalyst for efficient hydrogen evolution with visible and near-infrared (NIR) light activity is still a major challenge. Unlike the common behavior of gradually increasing the charge recombination while shrinking the bandgap, we present here a series of polymer nanoparticles (Pdots) based on ITIC and BTIC units with different π-linkers between the acceptor-donor-
Poesin som arbete och nåd - om Fanny Howe
Introduction to the works of American poet Fanny Howe (b. 1940), icluding translations of five poems.
Interaktion mellan elfordon och elnät : Fallstudier (delrapport 2)
Samhällets omställning till fossilfri energi innebär bland annat en ökad elektrifiering. I sin tur innebär en ökad elektrifiering också en högre efterfrågan på nya anslutningar till och behov av ökad kapacitet i elnätet. Syftet med delrapporten är att analysera två specifika fallstudier för att belysa utmaningar och möjligheter i interaktionen mellan elfordon och elnät. Den första fallstudien beha
Comparison of the ADNEX and ROMA risk prediction models for the diagnosis of ovarian cancer : a multicentre external validation in patients who underwent surgery
Background: Several diagnostic prediction models to help clinicians discriminate between benign and malignant adnexal masses are available. This study is a head-to-head comparison of the performance of the Assessment of Different NEoplasias in the adneXa (ADNEX) model with that of the Risk of Ovarian Malignancy Algorithm (ROMA). Methods: This is a retrospective study based on prospectively include
Diagnostic contribution of multi-frequency vibrometry to detection of peripheral neuropathy in type 1 diabetes mellitus compared with nerve conduction studies
Aim The aim was to assess the use of multi-frequency vibrometry (MFV) in detecting diabetic peripheral neuropathy (DPN) in type 1 diabetes in comparison to nerve conduction studies (NCS) and neurothesiometer (NT). Our objectives were to examine how VPTs correlated with NCS parameters, evaluate the efficacy of MFV in distinguishing DPN as well as to investigate whether MFV procedure could be based
Diagnostic pathways and treatment strategies in upper tract urothelial carcinoma in Sweden between 2015 and 2021 : a population-based survey
Objective: To report national data on diagnostics and treatment of upper tract urothelial carcinoma (UTUC) from the Swedish National Registry of Urinary Bladder Cancer (SNRUBC). Patients and methods: Data from 2015 to 2021 were retrieved, and descriptive analyses were performed regarding incidence, diagnostic modalities, preoperative tumor staging, quality indicators for treatment including the us
Christina Mattsson, Petter Winge och hans värld : En boktryckare, bokhandlare och utgivare i 1700-talets Nyköping
Musik - en underutnyttjad kraft för bättre hälsa
Tennisblockaden i Båstad 1968 : Vänsteraktivism och motmobilisering
The Båstad tennis protest of 1968: Left-wing activism and right-wing counter-mobilisationIn the spring of 1968, Sweden was supposed to play a Davis Cup tennis match against Rhodesia, a quasi-apartheid state in southern Africa. The game was scheduled to be played on 3 May in the small town of Båstad in southern Sweden. However, hundreds of anti-racist activists gathered and stopped the game from st
Assisting the implementation of screening for type 1 diabetes by using artificial intelligence on publicly available data
The type 1 diabetes community is coalescing around the benefits and advantages of early screening for disease risk. To be accepted by healthcare providers, regulatory authorities and payers, screening programmes need to show that the testing variables allow accurate risk prediction and that individualised risk-informed monitoring plans are established, as well as operational feasibility, cost-effe
Endocytic Roles of Glycans on Proteins and Lipids
Most cell surface proteins are decorated by glycans, and the plasma membrane is rich in glycosylated lipids. The mechanisms by which the enormous complexity of these glycan structures on proteins and lipids is exploited to control glycoprotein activity by setting their cell surface residence time and the ways by which they are taken up into cells are still under active investigation. Here, two mec
Development of an Implementation Strategy Tailored to Deliver Evidence-Based and Person-Centred Nursing Care for Patients with Community-Acquired Pneumonia : An Intervention Mapping Approach
Community-acquired pneumonia is a serious public health problem, and more so in older patients, leading to high morbidity and mortality. However, this problem can be reduced by optimising in-hospital nursing care. Accordingly, this study describes a systematic process of designing and developing a tailored theory- and research-based implementation strategy that supports registered nurses (RNs) in
Formation and Evolution of Protoplanetary Discs
Protoplanetary discs and the protostars they surround are formed from the gravitational collapse of molecularcloud cores. These discs consist primarily of gas, with a small but important dust component. The roughlymm-sized grains that make up the dust component are the building blocks of planets. Over a timescale of upto a few million years, the dust in protoplanetary discs is lost. Some of the du
Factors associated with sex differences in viral non-suppression in the Swedish InfCareHIV cohort : An observational real-world study
Objectives: Women living with HIV are underrepresented in clinical trials assessing outcomes of antiretroviral treatment (ART), justifying the need for observational studies. We investigated differences in viral non-suppression between women and men in the Swedish InfCareHIV cohort and analysed results in relation to biological and socio-demographic variables and patient-reported outcome measures
The effect of mixing on the dispersibility of adhesive mixtures for inhalation. Comparison of high shear and Turbula mixers
This study investigates the effect of different mixers and the applicability of the mixing energy (ME) concept to dry powder formulations for inhalation. With the aim to step-wise build and expand this concept, adhesive mixtures of 2 % budesonide and lactose carrier were investigated, both with 1 % magnesium stearate (MgSt) added in a ‘coating’ step, and without, the latter referred to as ‘naked’
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Sexual selection buffers the negative consequences of population fragmentation on adaptive plastic responses to increasing temperatures
Whether sexual selection facilitates or hampers the ability to plastically respond to novel environments might depend on population structure, via its effects on sexual interactions and associated fitness payoffs. Using experimentally evolved lines of the seed beetle Callosobruchus maculatus, we tested whether individuals evolving under different sexual selection (monogamy vs. polygamy) and popula
Towards healthcare access equality : Understanding spatial accessibility to healthcare services for wheelchair users
Considering that the number of wheelchair users is on the rise at the global level due to population aging, it is crucial to secure their rights to have adequate access to healthcare services. Spatial accessibility to healthcare services has been well recognized to influence people's health. However, research on healthcare accessibility of wheelchair users is scarce. This study proposes a barrier-